BGC0001452: sipanmycin biosynthetic gene cluster from Streptomyces sp. CS149
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Location: 1 - 93,434 nt. (total: 93,434 nt).
This entry is originally from NCBI GenBank LT986736.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0001452
Short description sipanmycin biosynthetic gene cluster from Streptomyces sp. CS149
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: LT986736.1
Compounds
  • sipanmycin
Species Streptomyces sp. CS149 [taxonomy]
References
Chemical products information
sipanmycin
(no structure information available)
C46H71N3O8
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • sipR1
 1 - 2895 (-) LuxR_family_transcriptional_regulator
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  • sipS3
 3176 - 4162 (-) Nucleoside-diphosphate sugar epimerase
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  • sipS2
 4185 - 5408 (-) nucleotide-glucose-dehydrogenase
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  • sipS1
 5610 - 6290 (-) N-acetylglucosaminyl deacetilase
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  • sipP5
 6584 - 18019 (+) Type I Modular PKS
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  • sipIB3
 18054 - 19391 (+) crotonyl-CoA_carboxylase_/_reductase
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  • sipIB1
 19388 - 20398 (+) 3-oxoacyl-(acyl_carrier_protein)_synthase_III
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  • SipIB2
 20395 - 21246 (+) 3-hydroxybutyryl-CoA_dehydrogenase
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  • sipS15
 21322 - 22305 (+) glycosyltransferase,_MGT_family
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  • sipP4
 22367 - 27247 (+) Type I Modular PKS
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  • sipP3
 27301 - 38199 (+) Type I Modular PKS
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  • sipR2
 38220 - 38987 (-) TetR_family_transcriptional_regulator
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  • sipT2
 39083 - 40093 (+) ABC_transporter_ATP-binding_protein
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  • sipT1
 40090 - 40887 (+) ABC-2_type_transporter
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  • sipB
 40972 - 41760 (-) thioesterase
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  • sipP2
 42122 - 58708 (+) Type I Modular PKS
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  • sipP1
 58714 - 70164 (+) Type I Modular PKS
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  • sipO1
 70327 - 71523 (-) cytochrome_P450
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  • sipL7
 71520 - 73169 (-) AMP-dependent_synthetase_and_ligase
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  • sipL6
 73312 - 73551 (+) acyl_carrier_protein
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  • sipL1
 73645 - 75324 (+) AMP-dependent_synthetase_and_ligase
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  • sipL2
 75266 - 76264 (-) malonyl_CoA-acyl_carrier_protein_transacylase
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  • sipL3
 76335 - 77729 (-) aminotransferase
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  • sipL4
 77750 - 79099 (-) lysine 2,3-aminomutase
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  • sipL5
 79134 - 80051 (-) L-proline amide hydrolase
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  • sipS4
 80255 - 81550 (+) glycosyltransferase,_MGT_family
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  • sipS7
 81699 - 82769 (+) glucose-1-phosphate_thymidylyltransferase
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  • sipS6
 82766 - 83815 (+) dTDP-glucose 4,6-dehydratase
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  • sipS10
 83812 - 85176 (+) NDP-hexose 2,3-dehydratase
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  • sipS8
 85245 - 85973 (-) N-methyltransferase
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  • sipS9
 86005 - 87171 (+) glycosyltransferase,_MGT_family
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  • sipS5a
 87206 - 88474 (-) C-methyltransferase
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  • sipO2
 88613 - 89929 (+) cytochrome_P450
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  • sipS14
 89952 - 91241 (+) glycosyltransferase,_MGT_family
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  • sipS11
 91238 - 92254 (+) NDP-hexose-3-ketoreductase
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  • sipS13
 92244 - 93434 (+) dTDP-4-dehydro-6-deoxyglucose aminotransferase
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Polyketide-specific information
Subclass Other
Cyclic? yes
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: RLZNHJMX3H6GI6NLV4CNQKTM, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Remove negative molecular mass
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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Modifications to original record
  • sipR1 was added
  • sipS3 was added
  • sipS2 was added
  • sipS1 was added
  • sipP5 was added
  • sipIB3 was added
  • sipIB1 was added
  • SipIB2 was added
  • sipS15 was added
  • sipP4 was added
  • sipP3 was added
  • sipR2 was added
  • sipT2 was added
  • sipT1 was added
  • sipB was added
  • sipP2 was added
  • sipP1 was added
  • sipO1 was added
  • sipL7 was added
  • sipL6 was added
  • sipL1 was added
  • sipL2 was added
  • sipL3 was added
  • sipL4 was added
  • sipL5 was added
  • sipS4 was added
  • sipS7 was added
  • sipS6 was added
  • sipS10 was added
  • sipS8 was added
  • sipS9 was added
  • sipS5a was added
  • sipO2 was added
  • sipS14 was added
  • sipS11 was added
  • sipS13 was added