BGC0001452: sipanmycin biosynthetic gene cluster from Streptomyces sp. CS149
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 1 - 93,434 nt. (total: 93,434 nt).
This entry is originally from NCBI GenBank LT986736.1, but has been modified (see Modifications tab for details).

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0001452
Short description sipanmycin biosynthetic gene cluster from Streptomyces sp. CS149
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
LT986736.1
via Knock-out studies
Compounds
  • sipanmycin
Species Streptomyces sp. CS149 [taxonomy]
References
Chemical products information
sipanmycin Evidence: NMR
(no structure information available)
C46H71N3O8
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • sipR1
1 - 2895 (-) LuxR_family_transcriptional_regulator
    copy AA seq
    copy Nt seq
    • sipS3
    3176 - 4162 (-) Nucleoside-diphosphate sugar epimerase
      copy AA seq
      copy Nt seq
      • sipS2
      4185 - 5408 (-) nucleotide-glucose-dehydrogenase
        copy AA seq
        copy Nt seq
        • sipS1
        5610 - 6290 (-) N-acetylglucosaminyl deacetilase
          copy AA seq
          copy Nt seq
          • sipP5
          6584 - 18019 (+) Type I Modular PKS
            copy AA seq
            copy Nt seq
            • sipIB3
            18054 - 19391 (+) crotonyl-CoA_carboxylase_/_reductase
              copy AA seq
              copy Nt seq
              • sipIB1
              19388 - 20398 (+) 3-oxoacyl-(acyl_carrier_protein)_synthase_III
                copy AA seq
                copy Nt seq
                • SipIB2
                20395 - 21246 (+) 3-hydroxybutyryl-CoA_dehydrogenase
                  copy AA seq
                  copy Nt seq
                  • sipS15
                  21322 - 22305 (+) glycosyltransferase,_MGT_family
                    copy AA seq
                    copy Nt seq
                    • sipP4
                    22367 - 27247 (+) Type I Modular PKS
                      copy AA seq
                      copy Nt seq
                      • sipP3
                      27301 - 38199 (+) Type I Modular PKS
                        copy AA seq
                        copy Nt seq
                        • sipR2
                        38220 - 38987 (-) TetR_family_transcriptional_regulator
                          copy AA seq
                          copy Nt seq
                          • sipT2
                          39083 - 40093 (+) ABC_transporter_ATP-binding_protein
                            copy AA seq
                            copy Nt seq
                            • sipT1
                            40090 - 40887 (+) ABC-2_type_transporter
                              copy AA seq
                              copy Nt seq
                              • sipB
                              40972 - 41760 (-) thioesterase
                                copy AA seq
                                copy Nt seq
                                • sipP2
                                42122 - 58708 (+) Type I Modular PKS
                                  copy AA seq
                                  copy Nt seq
                                  • sipP1
                                  58714 - 70164 (+) Type I Modular PKS
                                    copy AA seq
                                    copy Nt seq
                                    • sipO1
                                    70327 - 71523 (-) cytochrome_P450
                                      copy AA seq
                                      copy Nt seq
                                      • sipL7
                                      71520 - 73169 (-) AMP-dependent_synthetase_and_ligase
                                        copy AA seq
                                        copy Nt seq
                                        • sipL6
                                        73312 - 73551 (+) acyl_carrier_protein
                                          copy AA seq
                                          copy Nt seq
                                          • sipL1
                                          73645 - 75324 (+) AMP-dependent_synthetase_and_ligase
                                            copy AA seq
                                            copy Nt seq
                                            • sipL2
                                            75266 - 76264 (-) malonyl_CoA-acyl_carrier_protein_transacylase
                                              copy AA seq
                                              copy Nt seq
                                              • sipL3
                                              76335 - 77729 (-) aminotransferase
                                                copy AA seq
                                                copy Nt seq
                                                • sipL4
                                                77750 - 79099 (-) lysine 2,3-aminomutase
                                                  copy AA seq
                                                  copy Nt seq
                                                  • sipL5
                                                  79134 - 80051 (-) L-proline amide hydrolase
                                                    copy AA seq
                                                    copy Nt seq
                                                    • sipS4
                                                    80255 - 81550 (+) glycosyltransferase,_MGT_family
                                                      copy AA seq
                                                      copy Nt seq
                                                      • sipS7
                                                      81699 - 82769 (+) glucose-1-phosphate_thymidylyltransferase
                                                        copy AA seq
                                                        copy Nt seq
                                                        • sipS6
                                                        82766 - 83815 (+) dTDP-glucose 4,6-dehydratase
                                                          copy AA seq
                                                          copy Nt seq
                                                          • sipS10
                                                          83812 - 85176 (+) NDP-hexose 2,3-dehydratase
                                                            copy AA seq
                                                            copy Nt seq
                                                            • sipS8
                                                            85245 - 85973 (-) N-methyltransferase
                                                              copy AA seq
                                                              copy Nt seq
                                                              • sipS9
                                                              86005 - 87171 (+) glycosyltransferase,_MGT_family
                                                                copy AA seq
                                                                copy Nt seq
                                                                • sipS5a
                                                                87206 - 88474 (-) C-methyltransferase
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  • sipO2
                                                                  88613 - 89929 (+) cytochrome_P450
                                                                    copy AA seq
                                                                    copy Nt seq
                                                                    • sipS14
                                                                    89952 - 91241 (+) glycosyltransferase,_MGT_family
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • sipS11
                                                                      91238 - 92254 (+) NDP-hexose-3-ketoreductase
                                                                        copy AA seq
                                                                        copy Nt seq
                                                                        • sipS13
                                                                        92244 - 93434 (+) dTDP-4-dehydro-6-deoxyglucose aminotransferase
                                                                          copy AA seq
                                                                          copy Nt seq
                                                                          Biosynthesis information
                                                                          Annotation changelog

                                                                          Entry version: 4

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          Update chemical activity to schema version 2.11
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 3

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          Remove negative molecular mass
                                                                          • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          Updated bioactivity data
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 2

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          Migrated from v1.4
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 1

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          Submitted
                                                                          • (ID: RLZNHJMX3H6GI6NLV4CNQKTM)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          Detailed domain annotation
                                                                          Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                          A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                          Selected features only
                                                                          Show module domains
                                                                          Similar known gene clusters from MIBiG 4.0
                                                                          Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                          Click on reference genes to show details of similarities to genes within the current region.
                                                                          Click on an accession to open that entry in the MiBIG database.
                                                                          Modifications to original record
                                                                          • sipR1 was added
                                                                          • sipS3 was added
                                                                          • sipS2 was added
                                                                          • sipS1 was added
                                                                          • sipP5 was added
                                                                          • sipIB3 was added
                                                                          • sipIB1 was added
                                                                          • SipIB2 was added
                                                                          • sipS15 was added
                                                                          • sipP4 was added
                                                                          • sipP3 was added
                                                                          • sipR2 was added
                                                                          • sipT2 was added
                                                                          • sipT1 was added
                                                                          • sipB was added
                                                                          • sipP2 was added
                                                                          • sipP1 was added
                                                                          • sipO1 was added
                                                                          • sipL7 was added
                                                                          • sipL6 was added
                                                                          • sipL1 was added
                                                                          • sipL2 was added
                                                                          • sipL3 was added
                                                                          • sipL4 was added
                                                                          • sipL5 was added
                                                                          • sipS4 was added
                                                                          • sipS7 was added
                                                                          • sipS6 was added
                                                                          • sipS10 was added
                                                                          • sipS8 was added
                                                                          • sipS9 was added
                                                                          • sipS5a was added
                                                                          • sipO2 was added
                                                                          • sipS14 was added
                                                                          • sipS11 was added
                                                                          • sipS13 was added