BGC0001459: decaplanin biosynthetic gene cluster from Amycolatopsis regifaucium
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Location: 259,653 - 327,583 nt. (total: 67,931 nt).
This entry is originally from NCBI GenBank LOBU02000007.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001459
Short description decaplanin biosynthetic gene cluster from Amycolatopsis regifaucium
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "nkaur@imtech.res.in\nmayil@imtech.res.in"
Biosynthetic class(es)
  • NRP (Glycopeptide)
Loci NCBI GenBank: LOBU02000007.1
Compounds
  • decaplanin
Species Amycolatopsis regifaucium [taxonomy]
References
Chemical products information
decaplanin
Copy SMILES
C72H86Cl1N9O28
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ATP06_0208065
  • OKA09416.1
 259653 - 260612 (+) lactate dehydrogenase
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  • ATP06_0208070
  • OKA09417.1
  • vanB
 260605 - 261645 (+) D-alanine--(R)-lactate ligase
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  • ATP06_0208075
  • OKA09418.1
 261642 - 262250 (+) D-Ala-D-Ala dipeptidase VanX
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  • ATP06_0208080
  • OKA09661.1
 262657 - 263163 (+) peptidase M15
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  • ATP06_0208085
  • OKA09419.1
 263491 - 263865 (-) hypothetical protein
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  • ATP06_0208090
  • OKA09420.1
 264663 - 265628 (+) streptomycin biosynthesis protein
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  • ATP06_0208095
  • OKA09421.1
 265760 - 266584 (+) prephenate dehydrogenase
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  • ATP06_0208100
  • OKA09422.1
 266720 - 268672 (+) ABC transporter
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  • ATP06_0208105
  • OKA09423.1
 268675 - 278142 (+) non-ribosomal peptide synthetase
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  • ATP06_0208110
  • OKA09424.1
 278627 - 290818 (+) non-ribosomal peptide synthetase
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  • ATP06_0208115
  • OKA09425.1
 290859 - 296435 (+) non-ribosomal peptide synthetase
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  • ATP06_0208120
  • OKA09426.1
 296432 - 296641 (+) MbtH family protein
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  • ATP06_0208125
  • OKA09427.1
 296807 - 297982 (+) cytochrome
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  • ATP06_0208130
  • OKA09428.1
 298105 - 299301 (+) cytochrome
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  • ATP06_0208135
  • OKA09429.1
 299428 - 300648 (+) cytochrome
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  • ATP06_0208140
  • OKA09430.1
 300710 - 302185 (+) tryptophan halogenase
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  • ATP06_0208145
  • OKA09431.1
 302243 - 303433 (+) glycosyl transferase
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  • ATP06_0208150
  • OKA09432.1
 303430 - 304674 (+) glycosyl transferase
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  • ATP06_0208155
  • OKA09433.1
 304707 - 305939 (+) glycosyl transferase
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  • ATP06_0208160
  • OKA09434.1
 305985 - 307211 (+) SAM-dependent methyltransferase
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  • ATP06_0208165
  • OKA09662.1
 307222 - 308046 (+) PIG-L family deacetylase
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  • ATP06_0208170
  • OKA09663.1
 308086 - 308907 (+) SAM-dependent methyltransferase
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  • ATP06_0208175
  • OKA09435.1
 308993 - 310279 (-) GntR family transcriptional regulator
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  • ATP06_0208180
  • OKA09436.1
 310528 - 311358 (+) alpha/beta hydrolase
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  • ATP06_0208185
  • OKA09664.1
 311370 - 313118 (+) non-ribosomal peptide synthetase
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  • ATP06_0208190
  • OKA09437.1
 313133 - 314323 (+) NikQ protein
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  • ATP06_0208195
  • OKA09438.1
 314458 - 315501 (+) 4-hydroxyphenylpyruvate dioxygenase
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  • ATP06_0208200
  • OKA09439.1
 315498 - 316577 (+) alpha-hydroxy-acid oxidizing enzyme
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  • ATP06_0208205
  • OKA09440.1
 316626 - 317975 (+) cation/H(+) antiporter
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  • ATP06_0208210
  • OKA09441.1
 318207 - 319619 (+) NDP-hexose 2,3-dehydratase
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  • ATP06_0208215
  • OKA09442.1
 319621 - 320589 (+) NAD-dependent epimerase/dehydratase
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  • ATP06_0208220
  • OKA09443.1
 320586 - 321695 (+) daunorubicin biosynthesis sensory transduction protein DnrJ
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  • ATP06_0208225
 321719 - 322318 (+) dTDP-4-dehydrorhamnose 3,5-epimerase
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  • ATP06_0208230
  • OKA09444.1
 322493 - 323593 (+) type III polyketide synthase
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  • ATP06_0208235
  • OKA09445.1
 323587 - 324249 (+) enoyl-CoA hydratase
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  • ATP06_0208240
  • OKA09446.1
 324267 - 325550 (+) enoyl-CoA hydratase
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  • ATP06_0208245
  • OKA09447.1
 325547 - 326350 (+) enoyl-CoA hydratase
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  • ATP06_0208250
  • OKA09448.1
 326504 - 327583 (+) 3-deoxy-7-phosphoheptulonate synthase
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NRP-specific information
Subclass Glycopeptide
Cyclic? no
NRP-synthases
Gene Modules
ATP06_0208105
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: asparagine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
ATP06_0208110
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
ATP06_0208115
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
ATP06_0208185
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: O6YNIU5QQ6ENKKRTK6AUSAXS, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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