BGC0001477: lydicamycin biosynthetic gene cluster from Streptomyces sp. ID38640
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Location: 1 - 116,700 nt. (total: 116,700 nt).
This entry is originally from NCBI GenBank MG459168.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001477
Short description lydicamycin biosynthetic gene cluster from Streptomyces sp. ID38640
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
MG459168.1
via
Compounds
  • lydicamycin
Species Streptomyces sp. ID38640 [taxonomy]
References
Chemical products information
lydicamycin Evidence: NMR, Mass spectrometry
Copy SMILES
C47H74N4O10
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AVV61973.1
 142 - 2931 (+) response regulator
  • Regulation
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  • AVV61974.1
 3015 - 3839 (-) hypothetical protein
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    • AVV61975.1
    		 4355 - 6253 (+) putative signal transduction histidine kinase
    • Regulation
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    • AVV61976.1
    		 6235 - 6891 (+) LuxR family DNA-binding response regulator
    • Regulation
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    • AVV61977.1
    		 6945 - 7955 (-) malonyl CoA-acyl carrier protein transacylase
    • Scaffold biosynthesis
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    • AVV61978.1
    		 7958 - 8329 (-) putative secreted protein
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      • AVV61979.1
      		 9141 - 19934 (+) beta-ketoacyl synthase
      • Scaffold biosynthesis
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      • AVV61980.1
      		 19975 - 41175 (+) type I modular PKS
      • Scaffold biosynthesis
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      • AVV61981.1
      		 41219 - 51922 (+) type I modular PKS
      • Scaffold biosynthesis
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      • AVV61982.1
      		 51969 - 57500 (+) type I modular PKS
      • Scaffold biosynthesis
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      • AVV61983.1
      		 57508 - 74646 (+) type I modular polyketide synthase
      • Scaffold biosynthesis
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      • AVV61984.1
      		 74694 - 85661 (+) type I modular polyketide synthase
      • Scaffold biosynthesis
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      • AVV61985.1
      		 85698 - 95495 (+) beta-ketoacyl synthase
      • Scaffold biosynthesis
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      • AVV61986.1
      		 95668 - 96480 (+) hypothetical protein
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        • AVV61987.1
        		 96517 - 99612 (+) putative non-ribosomal peptide synthetase
        • Scaffold biosynthesis
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        • AVV61988.1
        		 99673 - 100575 (+) hypothetical protein
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          • AVV61989.1
          		 100607 - 106378 (+) beta-ketoacyl synthase
          • Scaffold biosynthesis
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          • AVV61990.1
          		 106449 - 107738 (-) cytochrome P450
          • Scaffold biosynthesis
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          • AVV61991.1
          		 108215 - 108307 (+) hypothetical protein
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            • AVV61992.1
            		 108304 - 109083 (+) putative membrane protein
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              • AVV61993.1
              		 109436 - 110197 (+) biosynthesis thioesterase
              • Scaffold biosynthesis
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              • AVV61994.1
              		 110270 - 111925 (-) amine oxidase
              • Scaffold biosynthesis
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              • AVV61995.1
              		 112369 - 113403 (+) AsnC family transcriptional regulator
              • Regulation
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              • AVV61996.1
              		 113393 - 114853 (-) amidase
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                • AVV61997.1
                		 114894 - 116447 (-) AbgT transporter
                • Transport
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                Biosynthesis information

                Biosynthetic modules

                Name
                17
                Type
                nrps-type1
                Genes
                AVV61987.1
                Substrates
                glycine (evidence: Sequence-based prediction)
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Name
                1
                Type
                pks-modular
                Genes
                AVV61979.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                Name
                2
                Type
                pks-modular
                Genes
                AVV61979.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                Name
                3
                Type
                pks-modular
                Genes
                AVV61980.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                Name
                4
                Type
                pks-modular
                Genes
                AVV61980.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                Name
                5
                Type
                pks-modular
                Genes
                AVV61980.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                Name
                6
                Type
                pks-modular
                Genes
                AVV61980.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                Name
                7
                Type
                pks-modular
                Genes
                AVV61981.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                Name
                8
                Type
                pks-modular
                Genes
                AVV61981.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                Name
                9
                Type
                pks-modular
                Genes
                AVV61982.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                Name
                10
                Type
                pks-modular
                Genes
                AVV61983.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                Name
                11
                Type
                pks-modular
                Genes
                AVV61983.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                Name
                12
                Type
                pks-modular
                Genes
                AVV61983.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                Name
                13
                Type
                pks-modular
                Genes
                AVV61984.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                Name
                14
                Type
                pks-modular
                Genes
                AVV61984.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                Name
                15
                Type
                pks-modular
                Genes
                AVV61985.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                Name
                16
                Type
                pks-modular
                Genes
                AVV61985.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                Name
                18
                Type
                pks-modular
                Genes
                AVV61989.1
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP), carrier (ACP)
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Fix DOI
                • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Corrected NRP module activity
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Removed gene names of 'No gene ID'
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Updated bioactivity data
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Updated NRP substrate specificities
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2019-10-16
                Updated compound(s) information (NPAtlas curation)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2018-08-06
                Submitted
                • (ID: LOOLDPJUN4VZBEJ3W5R2EHIG)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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