BGC0001519: aurantimycin A biosynthetic gene cluster from Streptomyces aurantiacus JA 4570
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Location: 1 - 64,790 nt. (total: 64,790 nt).
This entry is originally from NCBI GenBank AOPZ01000014.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001519
Short description aurantimycin A biosynthetic gene cluster from Streptomyces aurantiacus JA 4570
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
AOPZ01000014.1
1 - 64790
via
Compounds
  • aurantimycin A
Species Streptomyces aurantiacus JA 4570 [taxonomy]
References
Chemical products information
aurantimycin A Evidence:
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C38H64N8O14
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • STRAU_0320
  • EPH46581.1
 37 - 621 (+) putative metabolite transport protein YyaJ
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    • STRAU_0321
    • EPH46582.1
    		 726 - 980 (-) putative Polyketide synthase PksN
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      • STRAU_0322
      • EPH46583.1
      		 1246 - 1791 (+) putative NADH:riboflavin 5'-phosphate oxidoreductase
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        • STRAU_0323
        • EPH46584.1
        		 1894 - 3075 (+) putative Cytochrome-SU2
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          • STRAU_0324
          • EPH46585.1
          		 3188 - 4324 (-) hypothetical protein
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            • STRAU_0325
            • EPH46586.1
            		 4408 - 5346 (-) putative 3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2
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              • STRAU_0326
              • EPH46587.1
              		 5343 - 5591 (-) hypothetical protein
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                • STRAU_0327
                • EPH46588.1
                		 5653 - 5886 (-) putative dehydrogenase
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                  • STRAU_0328
                  • EPH46589.1
                  		 5898 - 6878 (-) putative Pyruvate dehydrogenase E1 component subunit beta
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                    • STRAU_0329
                    • EPH46590.1
                    		 6878 - 7717 (-) putative 3-methyl-2-oxobutanoate dehydrogenase subunit alpha
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                      • STRAU_0330
                      • EPH46591.1
                      		 8471 - 8686 (+) putative protein MbtH
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                        • STRAU_0331
                        • EPH46592.1
                        		 8818 - 9540 (+) hypothetical protein
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                          • STRAU_0332
                          • EPH46593.1
                          		 9633 - 11225 (+) putative Bacitracin synthase 3
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                            • STRAU_0333
                            • EPH46594.1
                            		 11256 - 11489 (+) hypothetical protein
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                              • STRAU_0334
                              • EPH46595.1
                              		 11776 - 12963 (+) putative Digeranylgeranylglycerophospholipid reductase 1
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                                • STRAU_0335
                                • EPH46596.1
                                		 13008 - 21656 (+) putative Linear gramicidin synthase subunit C
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                                  • STRAU_0336
                                  • EPH46597.1
                                  		 21668 - 29392 (+) putative Linear gramicidin synthase subunit C
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                                    • STRAU_0337
                                    • EPH46598.1
                                    		 29397 - 33221 (+) putative Dimodular nonribosomal peptide synthase
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                                      • STRAU_0338
                                      • EPH46599.1
                                      		 33280 - 34026 (+) putative cadicidin biosynthesis thioesterase
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                                        • STRAU_0339
                                        • EPH46600.1
                                        		 34151 - 35089 (+) putative Daunorubicin/doxorubicin resistance ATP-binding protein DrrA
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                                          • STRAU_0340
                                          • EPH46601.1
                                          		 35086 - 35847 (+) putative Daunorubicin/doxorubicin resistance ABC transporter permease protein DrrB
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                                            • STRAU_0341
                                            • EPH46602.1
                                            		 37018 - 37239 (+) putative Surfactin synthase subunit 1
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                                              • STRAU_0342
                                              • EPH46603.1
                                              		 37236 - 38486 (+) putative cytochrome
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                                                • STRAU_0343
                                                • EPH46604.1
                                                		 38483 - 39220 (+) putative Linear gramicidin dehydrogenase LgrE
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                                                  • STRAU_0344
                                                  • EPH46605.1
                                                  		 39330 - 42434 (+) putative Oleandomycin polyketide synthase, modules 5 and 6
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                                                    • STRAU_0345
                                                    • EPH46606.1
                                                    		 42459 - 48158 (+) putative Phenolphthiocerol synthesis polyketide synthase type I Pks15/1
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                                                      • STRAU_0346
                                                      • EPH46607.1
                                                      		 48169 - 54768 (+) putative Phenolphthiocerol synthesis polyketide synthase type I Pks15/1
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                                                        • STRAU_0347
                                                        • EPH46608.1
                                                        		 54770 - 57892 (+) putative Erythronolide synthase, modules 3 and 4
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                                                          • STRAU_0348
                                                          • EPH46609.1
                                                          		 57889 - 58008 (+) hypothetical protein
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                                                            • STRAU_0349
                                                            • EPH46610.1
                                                            		 58137 - 61322 (+) putative Dimodular nonribosomal peptide synthase
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                                                              • STRAU_0350
                                                              • EPH46611.1
                                                              		 61459 - 62205 (-) hypothetical protein
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                                                                • STRAU_0351
                                                                • EPH46612.1
                                                                		 62280 - 63062 (-) hypothetical protein
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                                                                  • STRAU_0352
                                                                  • EPH46613.1
                                                                  		 63753 - 64103 (-) hypothetical protein
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                                                                    • STRAU_0353
                                                                    • EPH46614.1
                                                                    		 64160 - 64789 (-) hypothetical protein
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                                                                      Biosynthesis information

                                                                      Biosynthetic modules

                                                                      Name
                                                                      Unk01
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      STRAU_0332
                                                                      Substrates
                                                                      valine, serine, leucine (evidence: ATP-PPi exchange assay [1])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk02
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      STRAU_0335
                                                                      Substrates
                                                                      piperazic acid (evidence: Structure-based inference, Sequence-based prediction, Homology)
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk03
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      STRAU_0335
                                                                      Substrates
                                                                      serine, alanine, phenylalanine (evidence: ATP-PPi exchange assay [1])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk04
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      STRAU_0336
                                                                      Substrates
                                                                      glycine, valine, alanine, serine (evidence: ATP-PPi exchange assay [1])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk05
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      STRAU_0336
                                                                      Substrates
                                                                      piperazic acid (evidence: Structure-based inference, Sequence-based prediction, Homology)
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk06
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      STRAU_0337
                                                                      Substrates
                                                                      alanine (evidence: ATP-PPi exchange assay [1])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk07
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      STRAU_0349
                                                                      Substrates
                                                                      3S-hydroxyleucine (evidence: Structure-based inference [1])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Annotation changelog

                                                                      Entry version: 4

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2022-10-07
                                                                      Update chemical activity to schema version 2.11
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 3

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2022-09-15
                                                                      Updated bioactivity data
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      2022-09-15
                                                                      Added NRP substrate specificities
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      2022-09-15
                                                                      Switch to GenBank accessions
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 2

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2019-10-16
                                                                      Migrated from v1.4
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      2019-10-16
                                                                      Updated compound(s) information (NPAtlas curation)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 1

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2018-08-06
                                                                      Submitted
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      Detailed domain annotation
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