BGC0001558: cosmomycin C biosynthetic gene cluster from Streptomyces sp. CNT302
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Location: 104,106 - 158,376 nt. (total: 54,271 nt).
This entry is originally from NCBI GenBank NZ_KB898282.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
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History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001558
Short description cosmomycin C biosynthetic gene cluster from Streptomyces sp. CNT302
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: NZ_KB898282.1
Compounds
  • cosmomycin C
Species Streptomyces sp. CNT302 [taxonomy]
References
Chemical products information
cosmomycin C
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C60H88N2O21
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • D329_RS0122250
  • WP_026281939.1
  • rfbA
 104106 - 104981 (-) glucose-1-phosphate thymidylyltransferase RfbA
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  • D329_RS0122255
  • WP_017947353.1
 105268 - 105522 (+) acyl carrier protein
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  • D329_RS32350
  • WP_018891721.1
 105794 - 106564 (+) AfsR/SARP family transcriptional regulator
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  • D329_RS0122265
  • WP_018891722.1
 106645 - 107502 (-) methyltransferase domain-containing protein
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  • D329_RS0122270
  • WP_026281940.1
 107690 - 108127 (+) ester cyclase
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  • D329_RS32355
  • WP_018891724.1
 108168 - 109277 (+) methyltransferase domain-containing protein
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  • D329_RS0122280
  • WP_018891725.1
 109282 - 110178 (+) alpha/beta fold hydrolase
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  • D329_RS0122285
  • WP_018891726.1
 110175 - 110972 (+) class I SAM-dependent methyltransferase
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  • D329_RS0122290
  • WP_018891727.1
 110969 - 112564 (+) FAD-dependent oxidoreductase
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  • D329_RS0122295
  • WP_018891728.1
 112656 - 113663 (-) Gfo/Idh/MocA family oxidoreductase
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  • D329_RS0122300
  • WP_018891729.1
 113859 - 114989 (+) hypothetical protein
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  • D329_RS0122305
  • WP_018891730.1
 114986 - 116305 (+) activator-dependent family glycosyltransferase
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  • D329_RS0122310
  • WP_018891731.1
  • rfbH
 116316 - 117617 (+) lipopolysaccharide biosynthesis protein RfbH
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  • D329_RS0122315
  • WP_018891732.1
  • fabG
 117625 - 118410 (+) 3-oxoacyl-ACP reductase FabG
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  • D329_RS0122320
  • WP_018891733.1
 118419 - 119777 (+) SRPBCC family protein
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  • D329_RS0122325
  • WP_018891734.1
 119958 - 120689 (-) SDR family oxidoreductase
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  • D329_RS0122330
  • WP_018891735.1
 120745 - 121152 (-) nuclear transport factor 2 family protein
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  • D329_RS0122335
  • WP_018891736.1
 121300 - 122079 (+) cyclase family protein
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  • D329_RS0122340
  • WP_018891737.1
 122135 - 122863 (+) class I SAM-dependent methyltransferase
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  • D329_RS0122345
  • WP_018891738.1
 122860 - 123969 (+) DegT/DnrJ/EryC1/StrS family aminotransferase
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  • D329_RS0122350
  • WP_018891739.1
 124045 - 125511 (-) NDP-hexose 2,3-dehydratase family protein
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  • D329_RS0122355
  • WP_018891740.1
 125508 - 126545 (-) NAD(P)-dependent oxidoreductase
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  • D329_RS0122360
  • WP_018891741.1
 126512 - 127138 (-) dTDP-4-dehydrorhamnose 3,5-epimerase family protein
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  • D329_RS0122365
  • WP_018891742.1
 127207 - 128499 (-) activator-dependent family glycosyltransferase
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  • D329_RS0122375
  • WP_018891744.1
 128786 - 129349 (+) PadR family transcriptional regulator
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  • D329_RS0122380
  • WP_018891745.1
 129730 - 130710 (+) hypothetical protein
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  • D329_RS0122390
  • WP_018891746.1
 130826 - 131161 (+) antibiotic biosynthesis monooxygenase
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  • D329_RS0122395
  • WP_017947381.1
 131158 - 132426 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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  • D329_RS0122400
  • WP_018891747.1
 132423 - 133667 (+) ketosynthase chain-length factor
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  • D329_RS0122405
  • WP_018891748.1
 133664 - 134698 (+) ketoacyl-ACP synthase III family protein
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  • D329_RS0122410
  • WP_018891749.1
 134695 - 135747 (+) acyltransferase domain-containing protein
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  • D329_RS0122415
  • WP_018891750.1
 135878 - 137128 (+) P450-derived glycosyltransferase activator
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  • D329_RS0122420
  • WP_018891751.1
 137163 - 138443 (+) activator-dependent family glycosyltransferase
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  • D329_RS0122425
  • WP_018891752.1
  • rfbB
 138465 - 139454 (+) dTDP-glucose 4,6-dehydratase
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  • D329_RS0122430
  • WP_017947388.1
 139523 - 140509 (+) daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein
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  • D329_RS0122435
  • WP_018891753.1
 140509 - 141339 (+) ABC transporter permease
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  • D329_RS0122440
  • WP_018891754.1
 141547 - 142071 (+) glutathione peroxidase
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  • D329_RS0122445
  • WP_018891755.1
 142125 - 144410 (+) excinuclease ABC subunit UvrA
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  • D329_RS0122450
  • WP_018891756.1
 144578 - 145126 (+) DinB family protein
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  • D329_RS32360
  • WP_051093176.1
 145151 - 145753 (+) PadR family transcriptional regulator
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  • D329_RS0122460
  • WP_018891758.1
 146013 - 146288 (+) DUF6343 family protein
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  • D329_RS32365
  • WP_018891759.1
 146483 - 147889 (+) YihY/virulence factor BrkB family protein
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  • D329_RS0122470
  • WP_017947396.1
 148248 - 148670 (+) DUF350 domain-containing protein
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  • D329_RS0122475
  • WP_018891760.1
 148887 - 149087 (+) hypothetical protein
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  • D329_RS0122480
  • WP_018891761.1
 149370 - 150248 (+) SigB/SigF/SigG family RNA polymerase sigma factor
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  • D329_RS0122485
  • WP_018891762.1
 150337 - 150687 (+) hypothetical protein
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  • D329_RS0122490
  • WP_017947400.1
 150697 - 151122 (-) CBS domain-containing protein
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  • D329_RS0122495
  • WP_018891763.1
 151514 - 151756 (+) DUF6381 family protein
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  • D329_RS0122500
  • WP_018891764.1
 151890 - 154214 (+) SpoIIE family protein phosphatase
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  • D329_RS0122505
  • WP_018891765.1
 154256 - 157300 (-) HAMP domain-containing protein
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  • D329_RS0122510
  • WP_017947404.1
 157481 - 157918 (-) ATP-binding protein
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  • D329_RS0122515
  • WP_018891766.1
 157984 - 158376 (-) STAS domain-containing protein
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Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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