BGC0001619: ibomycin biosynthetic gene cluster from Streptomyces sp. WAC2288
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 155,541 - 334,748 nt. (total: 179,208 nt).
This entry is originally from NCBI GenBank KJ159185.1, but has been modified (see Modifications tab for details).

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0001619
Short description ibomycin biosynthetic gene cluster from Streptomyces sp. WAC2288
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: incomplete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: KJ159185.1
Compounds
  • ibomycin
Species Streptomyces sp. WAC2288 [taxonomy]
References
Chemical products information
ibomycin
Copy SMILES
C91H156N2O40
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AKA59073.1
 155541 - 156227 (-) hydrolase
copy AA seq
copy Nt seq
  • AKA59074.1
 157363 - 158193 (+) metallophosphoesterase
copy AA seq
copy Nt seq
  • AKA59075.1
 158268 - 159086 (+) 4'-phosphopantetheinyl transferase
copy AA seq
copy Nt seq
  • AKA59076.1
 159175 - 160137 (+) NDP-glucose 4,6-dehydratase
copy AA seq
copy Nt seq
  • AKA59077.1
 160216 - 161487 (-) cytochrome P450
copy AA seq
copy Nt seq
  • AKA59078.1
 161688 - 162911 (-) glycosyltransferase
copy AA seq
copy Nt seq
  • AKA59079.1
 162908 - 164161 (-) glycosyltransferase
copy AA seq
copy Nt seq
  • AKA59080.1
 164158 - 165045 (-) NDP-glucose synthase
copy AA seq
copy Nt seq
  • AKA59081.1
 165053 - 166267 (-) glycosyltransferase
copy AA seq
copy Nt seq
  • AKA59082.1
 166554 - 168209 (+) beta-N-acetylhexosaminidase
copy AA seq
copy Nt seq
  • AKA59083.1
 168599 - 169402 (-) ABC transporter
copy AA seq
copy Nt seq
  • AKA59084.1
 169399 - 170382 (-) ABC transporter
copy AA seq
copy Nt seq
  • AKA59085.1
 170387 - 171643 (-) glycosyltransferase
copy AA seq
copy Nt seq
  • AKA59086.1
 171942 - 172697 (-) thioesterase
copy AA seq
copy Nt seq
  • AKA59087.1
 173382 - 174776 (+) NDP-hexose 2,3-dehydratase
copy AA seq
copy Nt seq
  • AKA59088.1
 175191 - 187340 (+) type-I PKS
copy AA seq
copy Nt seq
  • AKA59089.1
 187340 - 202438 (+) type-I PKS
copy AA seq
copy Nt seq
  • ibo19
 202470 - 213314 (+)
copy AA seq
copy Nt seq
  • AKA59090.1
 213316 - 227694 (+) type-I PKS
copy AA seq
copy Nt seq
  • AKA59091.1
 227769 - 247544 (+) type-I PKS
copy AA seq
copy Nt seq
  • AKA59092.1
 247541 - 261832 (+) type-I PKS
copy AA seq
copy Nt seq
  • AKA59093.1
 261829 - 273732 (+) type-I PKS
copy AA seq
copy Nt seq
  • AKA59094.1
 274110 - 274622 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AKA59095.1
 274790 - 276058 (+) sensor histidine kinase
copy AA seq
copy Nt seq
  • AKA59096.1
 276062 - 276712 (+) LuxR-family response regulator
copy AA seq
copy Nt seq
  • AKA59097.1
 276753 - 278027 (-) glycosyltransferase
copy AA seq
copy Nt seq
  • AKA59098.1
 278251 - 279207 (+) NDP-hexose 4-ketoreductase
copy AA seq
copy Nt seq
  • AKA59099.1
 279376 - 280686 (+) NDP-hexose-3-dehydratase
copy AA seq
copy Nt seq
  • AKA59100.1
 280820 - 281836 (+) NDP-hexose-3-reductase
copy AA seq
copy Nt seq
  • AKA59101.1
 281823 - 283079 (+) glycosyltransferase
copy AA seq
copy Nt seq
  • AKA59102.1
 283159 - 284355 (+) glycosyltransferase
copy AA seq
copy Nt seq
  • AKA59103.1
 284424 - 284522 (+) hypothetical protein
copy AA seq
copy Nt seq
  • AKV63202.1
 285352 - 289350 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AKA59104.1
 289431 - 291716 (-) LuxR-family transcriptional regulator
copy AA seq
copy Nt seq
  • AKA59105.1
 292481 - 295309 (+) LuxR-family transcriptional regulator
copy AA seq
copy Nt seq
  • AKA59106.1
 296289 - 297035 (+) LuxR-family transcriptional regulator
copy AA seq
copy Nt seq
  • AKA59107.1
 297151 - 297843 (+) two-component system regulator
copy AA seq
copy Nt seq
  • AKA59108.1
 297970 - 298407 (-) DNA-binding protein
copy AA seq
copy Nt seq
  • AKA59109.1
 298818 - 299921 (-) endochitinase
copy AA seq
copy Nt seq
  • AKA59110.1
 300169 - 301053 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AKA59111.1
 301212 - 301898 (-) hypothetical protein
copy AA seq
copy Nt seq
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: SJG3CBEHSM6A3I74YXLH6GLA, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added ibo19 gene described in paper but missing from NCBI data
  • Added compound information from pubchem
  • Updated location and completeness
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Modifications to original record
  • ibo19 was added