BGC0001700: niphimycin C biosynthetic gene cluster from Streptomyces sp. IMB7-145
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Location: 1 - 132,350 nt. (total: 132,350 nt).
This entry is originally from NCBI GenBank MF671979.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
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Biosynthesis
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001700
Short description niphimycin C biosynthetic gene cluster from Streptomyces sp. IMB7-145
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
MF671979.1
via
Compounds
  • niphimycin C
  • niphimycin D
  • niphimycin E
  • 17-O-methylniphimycin
  • niphimycin Iα
  • 19-O-malonylniphimycin
Species Streptomyces sp. IMB7-145 [taxonomy]
References
Chemical products information
niphimycin C [synonyms: 23-O-demalonyl-25-O-malonylniphimycin] Evidence: NMR [1]
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C59H103N3O18
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NPAtlas
niphimycin D [synonyms: 23-O-demalonyl-19,25-O-dimalonylniphimycin] Evidence: NMR [1]
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C62H105N3O21
Chemical database entries
NPAtlas
niphimycin E [synonyms: 15-O-malonylniphimycin] Evidence: NMR [1]
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C62H105N3O21
Chemical database entries
NPAtlas
17-O-methylniphimycin Evidence: NMR [1]
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Chemical database entries
NPAtlas
niphimycin Iα Evidence: Chemical derivatisation [1]
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Chemical database entries
NPAtlas
19-O-malonylniphimycin Evidence: NMR [1]
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AUO16393.1
  • npm1
 1 - 4644 (-) hypothetical protein
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    • AUO16394.1
    • npm2
    		 4791 - 5399 (-) TetR family transcriptional regulator
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      • AUO16395.1
      • npm3
      		 5544 - 6758 (-) cytochrome P450
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        • AUO16421.1
        • npm4
        		 7123 - 8325 (+) cytochrome P450
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          • AUO16396.1
          • npm5
          		 8405 - 8611 (+) ferredoxin
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            • AUO16397.1
            • npmB
            		 8868 - 20711 (+) polyketide synthase
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              • AUO16398.1
              • npmC
              		 20806 - 31188 (+) polyketide synthase
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                • AUO16399.1
                • npmD
                		 31271 - 41392 (+) polyketide synthase
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                  • AUO16400.1
                  • npmE
                  		 41418 - 55661 (+) polyketide synthase
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                    • AUO16401.1
                    • npmF
                    		 55738 - 80562 (+) polyketide synthase
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                      • AUO16402.1
                      • npmG
                      		 80608 - 90225 (+) polyketide synthase
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                        • AUO16422.1
                        • npmH
                        		 90283 - 100647 (+) polyketide synthase
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                          • AUO16403.1
                          • npmI
                          		 100698 - 108452 (+) polyketide synthase
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                            • AUO16423.1
                            • npmA
                            		 108574 - 115494 (+) polyketide synthase
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                              • AUO16404.1
                              • npm6
                              		 115617 - 117053 (+) 4-guanidinobutanoate:CoA ligase
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                                • AUO16405.1
                                • npm7
                                		 117050 - 118084 (+) 4-guanidinobutyryl-CoA:ACP acyltransferase
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                                  • AUO16406.1
                                  • npm8
                                  		 118240 - 118848 (+) TetR family transcriptional regulator
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                                    • AUO16407.1
                                    • npm9
                                    		 118953 - 119837 (+) hydrolase
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                                      • AUO16408.1
                                      • npm10
                                      		 119920 - 120300 (+) HxlR family transcriptional regulator
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                                        • AUO16409.1
                                        • npm11
                                        		 120380 - 120820 (-) endoribonuclease L-PSP
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                                          • AUO16410.1
                                          • npm12
                                          		 120973 - 122403 (-) hypothetical protein
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                                            • AUO16411.1
                                            • npm13
                                            		 122536 - 123816 (-) membrane protein
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                                              • AUO16412.1
                                              • npm14
                                              		 124107 - 124694 (-) XRE family transcriptional regulator
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                                                • AUO16413.1
                                                • npm15
                                                		 124792 - 125091 (+) methyltransferase
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                                                  • AUO16414.1
                                                  • npm16
                                                  		 125126 - 125635 (+) mini-circle protein
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                                                    • AUO16415.1
                                                    • npm17
                                                    		 125642 - 126271 (-) AcrR family DNA-binding transcriptional regulator
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                                                      • AUO16416.1
                                                      • npm18
                                                      		 126515 - 128056 (+) CoA-transferase family III
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                                                        • AUO16417.1
                                                        • npm19
                                                        		 128114 - 128899 (-) GntR-family transcriptional regulator
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                                                          • AUO16418.1
                                                          • npm20
                                                          		 129038 - 129841 (+) 4-guanidinobutyramide hydrolase
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                                                            • AUO16419.1
                                                            • npm21
                                                            		 129835 - 131271 (+) amino acid transporter
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                                                              • AUO16420.1
                                                              • npm22
                                                              		 131314 - 132180 (-) AraC-family transcriptional regulator
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                                                                Biosynthesis information
                                                                Annotation changelog

                                                                Entry version: next

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2024-04-23
                                                                MIBiG v4 annotathon
                                                                • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                                                                • (ID: U45G63MLSP33JST2JZS23R4V)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 4

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2022-10-07
                                                                Update chemical activity to schema version 2.11
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 3

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2022-09-15
                                                                Updated bioactivity data
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 2

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2019-10-16
                                                                Migrated from v1.4
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 1

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2018-08-06
                                                                Submitted
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                Detailed domain annotation
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