BGC0001740: phthoxazolin biosynthetic gene cluster from Streptomyces avermitilis
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Location: 1 - 100,000 nt. (total: 100,000 nt).
This entry is originally from NCBI GenBank LC315614.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001740
Short description phthoxazolin biosynthetic gene cluster from Streptomyces avermitilis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: LC315614.1
Compounds
  • phthoxazolin
Species Streptomyces avermitilis [taxonomy]
References
Chemical products information
phthoxazolin
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C16H22N2O3
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BBA21050.1
 151 - 1770 (+) putative secreted multicopper oxidase
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  • BBA21051.1
 2087 - 3166 (-) putative serine/threonine protein phosphatase
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  • BBA21052.1
 3609 - 3860 (+) hypothetical protein
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  • BBA21053.1
 3857 - 5974 (+) putative signal transduction histidine kinase
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  • BBA21054.1
 5998 - 7512 (-) putative glycerol kinase
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  • BBA21055.1
 7554 - 8321 (-) putative IclR-family transcriptional regulator
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  • BBA21056.1
 8468 - 8896 (+) putative histidine kinase-like ATPase
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  • BBA21057.1
 9184 - 9426 (+) hypothetical protein
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  • BBA21058.1
 9500 - 10501 (+) putative polyphosphate kinase
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  • BBA21059.1
 10568 - 11110 (-) hypothetical protein
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  • BBA21060.1
 11243 - 12688 (+) putative glyceraldehyde 3-phosphate dehydrogenase
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  • BBA21061.1
 13551 - 13964 (+) putative integrase
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  • BBA21062.1
 13961 - 15466 (+) putative integrase
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  • BBA21063.1
 15627 - 16193 (+) putative two-component sensor histidine kinase
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  • BBA21064.1
 16103 - 16444 (+) putative two-component response regulator
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  • BBA21065.1
 16553 - 16837 (+) putative LuxR-family transcriptional regulator
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  • BBA21066.1
 17095 - 17604 (-) putative SRPBCC family protein
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  • BBA21067.1
  • ptxA
 17716 - 20913 (-) putative di-domain acyl transferase
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  • BBA21068.1
  • ptxB
 20910 - 38729 (-) putative non-ribosomal peptide synthetase
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  • BBA21069.1
  • ptxC
 38780 - 41413 (-) putative modular polyketide synthase
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  • BBA21070.1
  • ptxD
 41434 - 42522 (-) putative OzmP-like protein
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  • BBA21071.1
  • ptxE
 42624 - 46088 (-) putative non-ribosomal peptide synthetase
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  • BBA21072.1
  • ptxF
 46085 - 60742 (-) putative modular polyketide synthase
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  • BBA21073.1
  • ptxG
 61089 - 71717 (-) putative non-ribosomal peptide synthetase
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  • BBA21074.1
  • ptxH
 71733 - 80315 (-) putative modular polyketide synthase
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  • BBA21075.1
 81458 - 81925 (+) hypothetical protein
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  • BBA21076.1
 81964 - 82884 (+) hypothetical protein
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  • BBA21077.1
 82974 - 84017 (+) putative inosine-5'-monophosphate dehydrogenase
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  • BBA21078.1
 84135 - 85688 (+) putative acetolactate synthase large subunit
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  • BBA21079.1
 85721 - 86608 (+) putative D-isomer specific 2-hydroxyacid dehydrogenase
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  • BBA21080.1
 86704 - 87936 (-) putative cytochrome P450
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  • BBA21081.1
 87883 - 88098 (+) hypothetical protein
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  • BBA21082.1
 88490 - 90070 (+) putative CoA ligase
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  • BBA21083.1
 90147 - 91376 (+) putative 5-aminolevulinate synthase
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  • BBA21084.1
 91424 - 92953 (+) putative 5-aminolevulinate CoA-ligase
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  • BBA21085.1
 93053 - 93730 (-) putative LuxR-family transcriptional regulator
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  • BBA21086.1
 94200 - 94946 (-) putative TetR-family transcriptional regulator
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  • BBA21087.1
 95050 - 96600 (+) putative MFS transporter
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  • BBA21088.1
 96674 - 97354 (-) putative 4'-phosphopantetheinyl transferase
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  • BBA21089.1
 98008 - 98508 (+) hypothetical protein
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  • BBA21090.1
 98505 - 98804 (+) hypothetical protein
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  • BBA21091.1
 98804 - 99157 (+) hypothetical protein
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  • BBA21092.1
 99124 - 99942 (+) hypothetical protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
ptxB
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
ptxE
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
ptxG
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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