BGC0001801: thiazostatin biosynthetic gene cluster from Streptomyces venezuelae ATCC 10712
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 555,257 - 584,067 nt. (total: 28,811 nt).
This entry is originally from NCBI GenBank FR845719.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001801
Short description thiazostatin biosynthetic gene cluster from Streptomyces venezuelae ATCC 10712
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: FR845719.1
Compounds
  • thiazostatin
  • watasemycin A
  • watasemycin B
  • 2-hydroxyphenylthiazoline enantiopyochelin
  • isopyochelin
Species Streptomyces venezuelae ATCC 10712 [taxonomy]
References
Chemical products information
thiazostatin
(no structure information available)
watasemycin A
Copy SMILES
C16H20N2O3S2
Chemical database entries
NPAtlas
watasemycin B
Copy SMILES
C16H20N2O3S2
Chemical database entries
NPAtlas
2-hydroxyphenylthiazoline enantiopyochelin
(no structure information available)
isopyochelin
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SVEN_0503
  • CCA53790.1
 555257 - 556507 (-) non-ribosomal peptide synthetase
copy AA seq
copy Nt seq
  • SVEN_0504
  • CCA53791.1
 556563 - 557837 (-) Na+ or H+ antiporter
copy AA seq
copy Nt seq
  • SVEN_0505
  • CCA53792.1
 557988 - 559934 (-) hypothetical protein
copy AA seq
copy Nt seq
  • SVEN_0506
  • CCA53793.1
 559994 - 561358 (-) Anthranilate synthase, aminase component
copy AA seq
copy Nt seq
  • SVEN_0507
  • CCA53794.1
 562062 - 562751 (+) putative transcriptional regulator
copy AA seq
copy Nt seq
  • SVEN_0508
  • CCA53795.1
 562748 - 563959 (+) putative reductoisomerase
copy AA seq
copy Nt seq
  • SVEN_0509
  • CCA53796.1
 564071 - 564757 (+) putative transcriptional regulator
copy AA seq
copy Nt seq
  • SVEN_0510
  • CCA53797.1
 564822 - 566423 (-) Long-chain-fatty-acid--CoA ligase
copy AA seq
copy Nt seq
  • SVEN_0511
  • CCA53798.1
 566493 - 567293 (-) thioesterase
copy AA seq
copy Nt seq
  • SVEN_0512
  • CCA53799.1
 567290 - 571834 (-) iron aquisition yersiniabactin synthesis enzyme
copy AA seq
copy Nt seq
  • SVEN_0513
  • CCA53800.1
 571891 - 573600 (-) putative ABC transporter
copy AA seq
copy Nt seq
  • SVEN_0514
  • CCA53801.1
 573597 - 575438 (-) Transport ATP-binding protein CydC
copy AA seq
copy Nt seq
  • SVEN_0515
  • CCA53802.1
 575754 - >577328 (+) radical SAM domain protein
copy AA seq
copy Nt seq
  • SVEN_0516
  • CCA53803.1
 577364 - 578590 (-) putative reductoisomerase in siderophore biosynthesis
copy AA seq
copy Nt seq
  • SVEN_0517
  • CCA53804.1
 578587 - 584067 (-) pyochelin synthetase F
copy AA seq
copy Nt seq
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
SVEN_0510
Module ?
Specificity: salicylic acid
Evidence for specificity:
  • Structure-based inference
  • Homology
SVEN_0512
Module ?
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
  • Homology
SVEN_0517
Module ?
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
  • Homology
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.