BGC0001848: diazaquinomycin H biosynthetic gene cluster from Micromonospora sp. B006
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Location: 3,038,865 - 3,097,062 nt. (total: 58,198 nt).
This entry is originally from NCBI GenBank CP030865.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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General
Compounds
Genes
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001848
Short description diazaquinomycin H biosynthetic gene cluster from Micromonospora sp. B006
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "key publication containing the BGC:Braesel et al. (2019) Diazaquinomycin biosynthetic gene clusters from marine and freshwater actionmycetes. J. Nat. Prod., in revision"
Biosynthetic class(es)
  • Other
Loci NCBI GenBank: CP030865.1
Compounds
  • diazaquinomycin H
  • diazaquinomycin J
Species Micromonospora sp. B006 [taxonomy]
References
Chemical products information
diazaquinomycin H
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C22H26N2O4
Chemical database entries
PubCHEM
diazaquinomycin J
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C23H28N2O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MicB006_2892
  • AXO35173.1
 3038865 - 3040082 (-) 2-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase II
  • Precursor biosynthesis
Sequence-based prediction
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  • MicB006_2893
  • AXO35174.1
 3040216 - 3041814 (-) hypothetical protein
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  • MicB006_2894
  • AXO35175.1
 3041874 - 3043553 (-) SSS sodium solute transporter superfamily
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  • MicB006_2895
  • AXO35176.1
 3043550 - 3043885 (-) putative membrane protein
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  • MicB006_2896
  • AXO35177.1
 3044080 - 3044820 (+) hypothetical protein
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  • MicB006_2897
  • AXO35178.1
 3044813 - 3045514 (-) short-chain dehydrogenase/reductase SDR
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  • MicB006_2898
  • AXO35179.1
 3045526 - 3046200 (-) isochorismatase
  • Precursor biosynthesis
Sequence-based prediction
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  • MicB006_2899
  • AXO35180.1
 3046233 - 3047018 (-) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
  • Precursor biosynthesis
Sequence-based prediction
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  • MicB006_2900
  • AXO35181.1
 3047018 - 3048187 (-) putative n-hydroxybenzoate hydroxylase
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  • MicB006_2901
  • AXO35182.1
 3048219 - 3049535 (-) phenylacetate-coenzyme A ligase
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  • MicB006_2902
  • AXO35183.1
 3049532 - 3050293 (-) hypothetical protein
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  • MicB006_2903
  • AXO35184.1
 3050319 - 3051422 (-) 37-dideoxy-D-threo-hepto-2 6-diulosonate synthase
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  • MicB006_2904
  • AXO35185.1
 3051454 - 3052278 (-) 2-amino-37-dideoxy-D-threo-hept-6-ulosonate synthase
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  • MicB006_2905
  • AXO35186.1
 3052294 - 3053577 (-) aspartokinase
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  • MicB006_2906
  • AXO35187.1
 3053813 - 3055777 (+) anthranilate synthase
  • Precursor biosynthesis
Sequence-based prediction
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  • MicB006_2907
  • AXO35188.1
 3055937 - 3056335 (+) hypothetical protein
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  • MicB006_2908
  • AXO35189.1
 3056436 - 3056825 (-) glyoxalase/bleomycin resistance protein/dioxygenase
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  • MicB006_2909
  • AXO35190.1
 3056836 - 3058797 (-) multicopper oxidase
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  • MicB006_2910
  • AXO35191.1
 3058818 - 3059273 (-) hypothetical protein
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  • MicB006_2911
  • AXO35192.1
 3059338 - 3059733 (-) hypothetical protein
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  • MicB006_2912
  • AXO35193.1
 3059926 - 3060588 (-) DNA-binding response regulator LuxR family
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  • MicB006_2913
  • AXO35194.1
 3060585 - 3061697 (-) putative two-component system sensor kinase
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  • MicB006_2914
  • AXO35195.1
 3061811 - 3062683 (-) hypothetical protein
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  • MicB006_2915
  • AXO35196.1
 3062752 - 3063927 (-) hydroxymethylglutaryl-CoA synthase
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  • MicB006_2916
  • AXO35197.1
 3063930 - 3064922 (-) hydroxymethylglutaryl-CoA reductase
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  • MicB006_2917
  • AXO35198.1
 3064982 - 3066064 (-) isopentenyl-diphosphate delta-isomerase
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  • MicB006_2918
  • AXO35199.1
 3066061 - 3067170 (-) phosphomevalonate kinase
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  • MicB006_2919
  • AXO35200.1
 3067167 - 3068207 (-) diphosphomevalonate decarboxylase
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  • MicB006_2920
  • AXO35201.1
 3068197 - 3069246 (-) mevalonate kinase
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  • MicB006_2921
  • AXO35202.1
 3069261 - 3070349 (-) geranylgeranyl pyrophosphate synthetase
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  • MicB006_2922
  • AXO35203.1
 3070800 - 3073439 (+) regulatory protein LuxR family
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  • MicB006_2923
  • AXO35204.1
 3073494 - 3075563 (-) transcriptional activator
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  • MicB006_2924
  • AXO35205.1
 3076156 - 3078288 (+) putative integral membrane export protein
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  • MicB006_2925
  • AXO35206.1
 3078372 - 3079376 (+) enoyl-[acyl-carrier-protein] reductase
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  • MicB006_2926
  • AXO35207.1
 3079510 - 3079926 (-) nuclear transport factor 2 family protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • MicB006_2927
  • AXO35208.1
 3080117 - 3080785 (+) flavoprotein WrbA
  • Unknown
Sequence-based prediction
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  • MicB006_2928
  • AXO35209.1
 3080837 - 3081514 (-) transcriptional regulator TetR family
  • Regulation
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  • MicB006_2929
  • AXO35210.1
 3081642 - 3082337 (+) NAD-dependent epimerase
  • Precursor biosynthesis
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  • MicB006_2930
  • AXO35211.1
 3082482 - 3083576 (+) mobile element protein/transposase
  • Unknown
Sequence-based prediction
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  • MicB006_2931
  • AXO35212.1
 3083622 - 3084590 (-) 3-oxoacyl-[acyl-carrier-protein] synthase KASIII
  • Precursor biosynthesis
Sequence-based prediction
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  • MicB006_2932
  • AXO35213.1
 3085008 - 3085832 (+) amidohydrolase
  • Precursor biosynthesis
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  • MicB006_2933
  • AXO35214.1
 3085837 - 3086646 (+) arylamine N-acetyltransferase 1
  • Scaffold biosynthesis
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  • MicB006_2934
  • AXO35215.1
 3086650 - 3087489 (+) arylamine N-acetyltransferase 1
  • Scaffold biosynthesis
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  • MicB006_2935
  • AXO35216.1
 3087486 - 3088538 (+) NADPH:quinone reductase
  • Precursor biosynthesis
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  • MicB006_2936
  • AXO35217.1
 3088479 - 3090176 (-) transcriptional regulator
  • Regulation
Sequence-based prediction
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  • MicB006_2937
  • AXO35218.1
 3090343 - 3090885 (+) SRPBCC family protein
  • Scaffold biosynthesis
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  • MicB006_2938
  • AXO35219.1
 3090895 - 3092466 (+) long-chain acyl-CoA synthetase
  • Precursor biosynthesis
Sequence-based prediction
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  • MicB006_2939
  • AXO35220.1
 3092463 - 3093671 (+) FAD-dependent oxidoreductase
  • Precursor biosynthesis
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  • MicB006_2940
  • AXO35221.1
 3093668 - 3095641 (+) FAD-binding protein
  • Precursor biosynthesis
Sequence-based prediction
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  • MicB006_2941
  • AXO35222.1
 3095638 - 3097062 (+) 3-carboxy-ciscis-muconate cycloisomerase
  • Precursor biosynthesis
Sequence-based prediction
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Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: GMXWAML5TKYYBXKHYBMH2DDT, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Fetch compound properties from PubChem
  • Cleaned up synonym list
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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