BGC0001869: griseoluteic acid biosynthetic gene cluster from Xenorhabdus szentirmaii DSM 16338
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Location: 1,247,478 - 1,268,444 nt. (total: 20,967 nt).
This entry is originally from NCBI GenBank NIBV01000002.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
Tailoring
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001869
Short description griseoluteic acid biosynthetic gene cluster from Xenorhabdus szentirmaii DSM 16338
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Uses the phenazine produced in BGC0001868 as precursor"
Biosynthetic class(es)
  • other (phenazine)
  • NRPS (Type I)
Loci
NIBV01000002.1
1256653 - 1268444
via Heterologous expression, Gene expression correlated with compound production, Knock-out studies
Compounds
  • griseoluteic acid
  • demethoxygriseoluteic acid
  • phenaszentine A
  • phenaszentine C
  • phenaszenketide C
  • phenaszenketide D
Species Xenorhabdus szentirmaii DSM 16338 [taxonomy]
References
Chemical products information
griseoluteic acid Evidence: NMR, Mass spectrometry
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Chemical database entries
PubCHEM
demethoxygriseoluteic acid Evidence: NMR, Mass spectrometry, Chemical derivatisation
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Chemical database entries
PubCHEM
phenaszentine A Evidence: Mass spectrometry, X-ray crystallography, Total synthesis
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C19H19N3O4
phenaszentine C Evidence: NMR, Mass spectrometry, Chemical derivatisation
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C21H23N3O5
phenaszenketide C Evidence: NMR, Mass spectrometry
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C20H16N2O3
phenaszenketide D Evidence: NMR, Mass spectrometry
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C18H14N2O4
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Xsze_03174
  • PHM32428.1
 1256654 - 1257043 (+) glyoxalase
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    • Xsze_03175
    • PHM32429.1
    		 1257478 - 1257963 (+) phenazine biosynthesis protein PhzB
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      • Xsze_03176
      • PHM32430.1
      		 1258318 - 1258959 (+) putative pyrodoxamine 5'-phosphate oxidase
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        • Xsze_03177
        • PHM32431.1
        		 1258940 - 1260037 (+) hypothetical protein
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          • Xsze_03178
          • PHM32432.1
          		 1260037 - 1261434 (+) 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
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            • Xsze_03179
            • PHM32433.1
            		 1261500 - 1262189 (+) tellurite resistance protein TehB
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              • Xsze_03180
              • PHM32434.1
              		 1262216 - 1263649 (+) MFS family major facilitator transporter
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                • Xsze_03181
                • PHM32435.1
                		 1263667 - 1264458 (+) 3-ketoacyl-ACP-reductase CylG
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                  • Xsze_03182
                  • PHM32436.1
                  		 1264451 - 1265608 (+) acyl-CoA dehydrogenase
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                    • Xsze_03183
                    • PHM32437.1
                    		 1265691 - 1267187 (+) Amino acid adenylation
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                      • Xsze_03184
                      • PHM32438.1
                      		 1267177 - 1267422 (+) hypothetical protein
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                        • Xsze_03185
                        • PHM32439.1
                        		 1267419 - 1268444 (+) 3-oxoacyl-ACP synthase
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                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          1
                          Type
                          nrps-type1
                          Genes
                          Xsze_03183 Xsze_03184 Xsze_03185
                          Substrates
                          isoleucine, leucine, valine (evidence: )
                          Integrated Monomers
                          Domains
                          adenylation
                          Annotation changelog

                          Entry version: 3

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-10-07
                          Update chemical activity to schema version 2.11
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Fixed genomic coordinates
                          • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Un-retire entry
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Cleaned up synonym list
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Changed amino acid substrates to lower case
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2019-10-16
                          Submitted
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          Tailoring functions
                          Tailoring enzymes detected in this region
                          Oxidoreductases: dehydrogenase
                          Xsze_03181: short-chain dehydrogenase/reductase SDR
                          smcogs
                          SMCOG1001: short-chain dehydrogenase/reductase SDR
                          Xsze_03182: acyl-CoA dehydrogenase type 2
                          smcogs
                          SMCOG1191: acyl-CoA dehydrogenase type 2
                          Ligases: ligase synthase
                          Xsze_03183: AMP-dependent synthetase and ligase
                          smcogs
                          SMCOG1002: AMP-dependent synthetase and ligase
                          Xsze_03185: 3-oxoacyl-(acyl carrier protein) synthase III
                          smcogs
                          SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III
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