BGC0001877: cyphomycin biosynthetic gene cluster from Streptomyces sp. ISID311
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Location: 427,967 - 622,305 nt. (total: 194,339 nt).
This entry is originally from NCBI GenBank VOQD01000001.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001877
Short description cyphomycin biosynthetic gene cluster from Streptomyces sp. ISID311
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Polyene)
Loci NCBI GenBank: VOQD01000001.1
Compounds
  • cyphomycin
Species Streptomyces sp. ISID311 [taxonomy]
References
Chemical products information
cyphomycin
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C77H122O26
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • FS847_01740
  • TXC99989.1
 427967 - 431086 (+) non-ribosomal peptide synthetase
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  • FS847_01745
  • TXD00256.1
 431074 - 432288 (-) serine hydrolase
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  • FS847_01750
  • TXC99990.1
 432413 - 433096 (-) TetR family transcriptional regulator
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  • FS847_01755
  • TXC99991.1
 433387 - 434640 (+) glycosyltransferase family 1 protein
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  • FS847_01760
  • TXC99992.1
 434686 - 435324 (-) adenylyl-sulfate kinase
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  • FS847_01765
  • TXC99993.1
 435326 - 436615 (-) sulfotransferase
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  • FS847_01770
  • TXC99994.1
 436873 - 437604 (-) hypothetical protein
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  • FS847_01775
  • TXC99995.1
 438009 - 439241 (+) class I SAM-dependent methyltransferase
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  • FS847_01780
  • TXC99996.1
 439546 - 440184 (+) dTDP-4-keto-6-deoxy-D-glucose epimerase
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  • FS847_01785
  • TXD00257.1
 440233 - 441180 (+) NAD(P)-dependent oxidoreductase
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  • FS847_01790
  • TXC99997.1
 441369 - 442151 (+) ATP-binding cassette domain-containing protein
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  • FS847_01795
  • TXD00258.1
 442273 - 443028 (+) ABC transporter permease
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  • FS847_01800
  • TXC99998.1
 443110 - 443343 (-) tautomerase pptA
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  • FS847_01805
  • TXD00259.1
 443393 - 447208 (-) amino acid adenylation domain-containing protein
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  • FS847_01810
  • TXC99999.1
 447217 - 448152 (-) EamA family transporter
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  • FS847_01815
  • TXD00260.1
 448506 - 449465 (+) HD domain-containing protein
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  • FS847_01820
  • TXD00001.1
 449531 - 450457 (-) LysR family transcriptional regulator
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  • FS847_01825
  • TXD00002.1
 450590 - 451852 (+) MFS transporter
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  • FS847_01830
  • TXD00003.1
 451953 - 453347 (-) cytochrome P450
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  • FS847_01835
  • TXD00004.1
 453704 - 456475 (+) phosphoenolpyruvate synthase
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  • FS847_01840
  • TXD00005.1
 456472 - 458127 (+) hypothetical protein
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  • FS847_01845
  • TXD00006.1
 458257 - 459441 (+) SDR family oxidoreductase
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  • FS847_01850
  • TXD00007.1
 459438 - 460433 (+) nucleoside-diphosphate kinase
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  • FS847_01855
  • TXD00008.1
 460449 - 461426 (+) A-factor biosynthesis protein
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  • FS847_01860
  • TXD00009.1
 461428 - 462078 (+) nitroreductase family protein
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  • FS847_01865
  • TXD00010.1
 462066 - 462983 (+) hypothetical protein
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  • FS847_01870
  • TXD00011.1
 463000 - 464292 (+) amidohydrolase family protein
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  • FS847_01875
  • TXD00012.1
 464369 - 465238 (+) SAM-dependent methyltransferase
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  • FS847_01880
  • TXD00013.1
 465248 - 466441 (+) glycosyl transferase
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  • FS847_01885
  • TXD00014.1
 466576 - 466800 (-) transposase
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  • FS847_01890
  • TXD00015.1
 466951 - 467250 (-) hypothetical protein
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  • FS847_01895
  • TXD00016.1
 467485 - 467931 (-) transposase
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  • FS847_01900
  • TXD00017.1
 467784 - 468218 (-) cold shock domain-containing protein
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  • FS847_01905
  • TXD00018.1
 468407 - 469444 (-) 3-oxoacyl-ACP synthase
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  • FS847_01910
  • TXD00261.1
 469473 - 476630 (-) AMP-binding protein
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  • FS847_01915
  • TXD00019.1
  • rfbH
 477160 - 478461 (+) lipopolysaccharide biosynthesis protein RfbH
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  • FS847_01920
  • TXD00262.1
 478549 - 479742 (-) glycosyl transferase
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  • FS847_01925
  • TXD00263.1
 479880 - 480842 (-) NAD(P)-dependent oxidoreductase
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  • FS847_01930
  • TXD00020.1
  • rfbB
 480893 - 481894 (-) dTDP-glucose 4,6-dehydratase
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  • FS847_01935
  • TXD00021.1
 481996 - 483063 (-) glucose-1-phosphate thymidylyltransferase
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  • FS847_01940
  • TXD00022.1
 483130 - 484386 (-) activator-dependent family glycosyltransferase
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  • FS847_01945
  • TXD00264.1
 484879 - 486018 (+) cytochrome P450
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  • FS847_01950
  • TXD00023.1
 486048 - 486251 (-) ferredoxin
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  • FS847_01955
  • TXD00024.1
 486430 - 497364 (-) SDR family NAD(P)-dependent oxidoreductase
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  • FS847_01960
  • TXD00025.1
 497411 - 513178 (-) SDR family NAD(P)-dependent oxidoreductase
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  • FS847_01965
  • TXD00265.1
 513224 - 525361 (-) SDR family NAD(P)-dependent oxidoreductase
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  • FS847_01970
 526028 - 527926 (-) acyltransferase domain-containing protein
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  • FS847_01975
 528275 - 529825 (-) type I polyketide synthase
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  • FS847_01980
 530144 - 531505 (-) SDR family NAD(P)-dependent oxidoreductase
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  • FS847_01985
 535874 - 538612 (-) type I polyketide synthase
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  • FS847_01990
  • TXD00026.1
 538662 - 554417 (-) SDR family NAD(P)-dependent oxidoreductase
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  • FS847_01995
  • TXD00266.1
 554476 - 566334 (-) SDR family NAD(P)-dependent oxidoreductase
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  • FS847_02000
  • TXD00027.1
 566750 - 567886 (+) molybdopterin-dependent oxidoreductase
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  • FS847_02005
  • TXD00028.1
 567883 - 568284 (+) hypothetical protein
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  • FS847_02010
  • TXD00029.1
 568339 - 569355 (-) NADP-dependent oxidoreductase
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  • FS847_02015
  • TXD00030.1
 569469 - 570455 (+) helix-turn-helix domain-containing protein
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  • FS847_02020
  • TXD00031.1
 570516 - 573722 (-) cytochrome P450
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  • FS847_02025
  • TXD00032.1
 573860 - 574510 (+) TetR family transcriptional regulator
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  • FS847_02030
  • TXD00033.1
 574690 - 589527 (-) SDR family NAD(P)-dependent oxidoreductase
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  • FS847_02035
  • TXD00034.1
 589574 - 602305 (-) SDR family NAD(P)-dependent oxidoreductase
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  • FS847_02040
  • TXD00267.1
 602669 - 604081 (+) NDP-hexose 2,3-dehydratase
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  • FS847_02045
  • TXD00035.1
 604261 - 604905 (-) TetR family transcriptional regulator
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  • FS847_02050
  • TXD00036.1
 604932 - 605705 (-) FadR family transcriptional regulator
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  • FS847_02055
  • TXD00037.1
 606743 - 609562 (+) AAA family ATPase
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  • FS847_02060
  • TXD00038.1
 610016 - 610756 (+) LuxR family transcriptional regulator
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  • FS847_02065
  • TXD00039.1
 611446 - 614667 (+) AAA family ATPase
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  • FS847_02070
  • TXD00040.1
 614763 - 615479 (-) 4'-phosphopantetheinyl transferase superfamily protein
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  • FS847_02075
  • TXD00041.1
 615852 - 616070 (+) hypothetical protein
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  • FS847_02080
  • TXD00042.1
 616409 - 616909 (+) hypothetical protein
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  • FS847_02085
  • TXD00268.1
 617637 - 618116 (+) hypothetical protein
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  • FS847_02090
  • TXD00043.1
 618113 - 619396 (+) HAMP domain-containing histidine kinase
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  • FS847_02095
  • TXD00044.1
 619601 - 621685 (+) SpoIIE family protein phosphatase
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Polyketide-specific information
Subclass Polyene
Cyclic? yes
Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: D573CRWGF3Z73VN2NY3DHI3L, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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