BGC0001877: cyphomycin biosynthetic gene cluster from Streptomyces sp. ISID311
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 423,393 - 622,305 nt. (total: 198,913 nt).
This entry is originally from NCBI GenBank VOQD01000001.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001877
Short description cyphomycin biosynthetic gene cluster from Streptomyces sp. ISID311
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
VOQD01000001.1
427967 - 622305
via
Compounds
  • cyphomycin
Species Streptomyces sp. ISID311 [taxonomy]
References
Chemical products information
cyphomycin Evidence:
Copy SMILES
C77H122O26
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • FS847_01740
  • TXC99989.1
 427967 - 431086 (+) non-ribosomal peptide synthetase
    copy AA seq
    copy Nt seq
    • FS847_01745
    • TXD00256.1
    		 431074 - 432288 (-) serine hydrolase
      copy AA seq
      copy Nt seq
      • FS847_01750
      • TXC99990.1
      		 432413 - 433096 (-) TetR family transcriptional regulator
        copy AA seq
        copy Nt seq
        • FS847_01755
        • TXC99991.1
        		 433387 - 434640 (+) glycosyltransferase family 1 protein
          copy AA seq
          copy Nt seq
          • FS847_01760
          • TXC99992.1
          		 434686 - 435324 (-) adenylyl-sulfate kinase
            copy AA seq
            copy Nt seq
            • FS847_01765
            • TXC99993.1
            		 435326 - 436615 (-) sulfotransferase
              copy AA seq
              copy Nt seq
              • FS847_01770
              • TXC99994.1
              		 436873 - 437604 (-) hypothetical protein
                copy AA seq
                copy Nt seq
                • FS847_01775
                • TXC99995.1
                		 438009 - 439241 (+) class I SAM-dependent methyltransferase
                  copy AA seq
                  copy Nt seq
                  • FS847_01780
                  • TXC99996.1
                  		 439546 - 440184 (+) dTDP-4-keto-6-deoxy-D-glucose epimerase
                    copy AA seq
                    copy Nt seq
                    • FS847_01785
                    • TXD00257.1
                    		 440233 - 441180 (+) NAD(P)-dependent oxidoreductase
                      copy AA seq
                      copy Nt seq
                      • FS847_01790
                      • TXC99997.1
                      		 441369 - 442151 (+) ATP-binding cassette domain-containing protein
                        copy AA seq
                        copy Nt seq
                        • FS847_01795
                        • TXD00258.1
                        		 442273 - 443028 (+) ABC transporter permease
                          copy AA seq
                          copy Nt seq
                          • FS847_01800
                          • TXC99998.1
                          		 443110 - 443343 (-) tautomerase pptA
                            copy AA seq
                            copy Nt seq
                            • FS847_01805
                            • TXD00259.1
                            		 443393 - 447208 (-) amino acid adenylation domain-containing protein
                              copy AA seq
                              copy Nt seq
                              • FS847_01810
                              • TXC99999.1
                              		 447217 - 448152 (-) EamA family transporter
                                copy AA seq
                                copy Nt seq
                                • FS847_01815
                                • TXD00260.1
                                		 448506 - 449465 (+) HD domain-containing protein
                                  copy AA seq
                                  copy Nt seq
                                  • FS847_01820
                                  • TXD00001.1
                                  		 449531 - 450457 (-) LysR family transcriptional regulator
                                    copy AA seq
                                    copy Nt seq
                                    • FS847_01825
                                    • TXD00002.1
                                    		 450590 - 451852 (+) MFS transporter
                                      copy AA seq
                                      copy Nt seq
                                      • FS847_01830
                                      • TXD00003.1
                                      		 451953 - 453347 (-) cytochrome P450
                                        copy AA seq
                                        copy Nt seq
                                        • FS847_01835
                                        • TXD00004.1
                                        		 453704 - 456475 (+) phosphoenolpyruvate synthase
                                          copy AA seq
                                          copy Nt seq
                                          • FS847_01840
                                          • TXD00005.1
                                          		 456472 - 458127 (+) hypothetical protein
                                            copy AA seq
                                            copy Nt seq
                                            • FS847_01845
                                            • TXD00006.1
                                            		 458257 - 459441 (+) SDR family oxidoreductase
                                              copy AA seq
                                              copy Nt seq
                                              • FS847_01850
                                              • TXD00007.1
                                              		 459438 - 460433 (+) nucleoside-diphosphate kinase
                                                copy AA seq
                                                copy Nt seq
                                                • FS847_01855
                                                • TXD00008.1
                                                		 460449 - 461426 (+) A-factor biosynthesis protein
                                                  copy AA seq
                                                  copy Nt seq
                                                  • FS847_01860
                                                  • TXD00009.1
                                                  		 461428 - 462078 (+) nitroreductase family protein
                                                    copy AA seq
                                                    copy Nt seq
                                                    • FS847_01865
                                                    • TXD00010.1
                                                    		 462066 - 462983 (+) hypothetical protein
                                                      copy AA seq
                                                      copy Nt seq
                                                      • FS847_01870
                                                      • TXD00011.1
                                                      		 463000 - 464292 (+) amidohydrolase family protein
                                                        copy AA seq
                                                        copy Nt seq
                                                        • FS847_01875
                                                        • TXD00012.1
                                                        		 464369 - 465238 (+) SAM-dependent methyltransferase
                                                          copy AA seq
                                                          copy Nt seq
                                                          • FS847_01880
                                                          • TXD00013.1
                                                          		 465248 - 466441 (+) glycosyl transferase
                                                            copy AA seq
                                                            copy Nt seq
                                                            • FS847_01885
                                                            • TXD00014.1
                                                            		 466576 - 466800 (-) transposase
                                                              copy AA seq
                                                              copy Nt seq
                                                              • FS847_01890
                                                              • TXD00015.1
                                                              		 466951 - 467250 (-) hypothetical protein
                                                                copy AA seq
                                                                copy Nt seq
                                                                • FS847_01895
                                                                • TXD00016.1
                                                                		 467485 - 467931 (-) transposase
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  • FS847_01900
                                                                  • TXD00017.1
                                                                  		 467784 - 468218 (-) cold shock domain-containing protein
                                                                    copy AA seq
                                                                    copy Nt seq
                                                                    • FS847_01905
                                                                    • TXD00018.1
                                                                    		 468407 - 469444 (-) 3-oxoacyl-ACP synthase
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • FS847_01910
                                                                      • TXD00261.1
                                                                      		 469473 - 476630 (-) AMP-binding protein
                                                                        copy AA seq
                                                                        copy Nt seq
                                                                        • FS847_01915
                                                                        • TXD00019.1
                                                                        • rfbH
                                                                        		 477160 - 478461 (+) lipopolysaccharide biosynthesis protein RfbH
                                                                          copy AA seq
                                                                          copy Nt seq
                                                                          • FS847_01920
                                                                          • TXD00262.1
                                                                          		 478549 - 479742 (-) glycosyl transferase
                                                                            copy AA seq
                                                                            copy Nt seq
                                                                            • FS847_01925
                                                                            • TXD00263.1
                                                                            		 479880 - 480842 (-) NAD(P)-dependent oxidoreductase
                                                                              copy AA seq
                                                                              copy Nt seq
                                                                              • FS847_01930
                                                                              • TXD00020.1
                                                                              • rfbB
                                                                              		 480893 - 481894 (-) dTDP-glucose 4,6-dehydratase
                                                                                copy AA seq
                                                                                copy Nt seq
                                                                                • FS847_01935
                                                                                • TXD00021.1
                                                                                		 481996 - 483063 (-) glucose-1-phosphate thymidylyltransferase
                                                                                  copy AA seq
                                                                                  copy Nt seq
                                                                                  • FS847_01940
                                                                                  • TXD00022.1
                                                                                  		 483130 - 484386 (-) activator-dependent family glycosyltransferase
                                                                                    copy AA seq
                                                                                    copy Nt seq
                                                                                    • FS847_01945
                                                                                    • TXD00264.1
                                                                                    		 484879 - 486018 (+) cytochrome P450
                                                                                      copy AA seq
                                                                                      copy Nt seq
                                                                                      • FS847_01950
                                                                                      • TXD00023.1
                                                                                      		 486048 - 486251 (-) ferredoxin
                                                                                        copy AA seq
                                                                                        copy Nt seq
                                                                                        • FS847_01955
                                                                                        • TXD00024.1
                                                                                        		 486430 - 497364 (-) SDR family NAD(P)-dependent oxidoreductase
                                                                                          copy AA seq
                                                                                          copy Nt seq
                                                                                          • FS847_01960
                                                                                          • TXD00025.1
                                                                                          		 497411 - 513178 (-) SDR family NAD(P)-dependent oxidoreductase
                                                                                            copy AA seq
                                                                                            copy Nt seq
                                                                                            • FS847_01965
                                                                                            • TXD00265.1
                                                                                            		 513224 - 525361 (-) SDR family NAD(P)-dependent oxidoreductase
                                                                                              copy AA seq
                                                                                              copy Nt seq
                                                                                              • FS847_01970
                                                                                              		 526028 - 527926 (-) acyltransferase domain-containing protein
                                                                                                copy AA seq
                                                                                                copy Nt seq
                                                                                                • FS847_01975
                                                                                                		 528275 - 529825 (-) type I polyketide synthase
                                                                                                  copy AA seq
                                                                                                  copy Nt seq
                                                                                                  • FS847_01980
                                                                                                  		 530144 - 531505 (-) SDR family NAD(P)-dependent oxidoreductase
                                                                                                    copy AA seq
                                                                                                    copy Nt seq
                                                                                                    • FS847_01985
                                                                                                    		 535874 - 538612 (-) type I polyketide synthase
                                                                                                      copy AA seq
                                                                                                      copy Nt seq
                                                                                                      • FS847_01990
                                                                                                      • TXD00026.1
                                                                                                      		 538662 - 554417 (-) SDR family NAD(P)-dependent oxidoreductase
                                                                                                        copy AA seq
                                                                                                        copy Nt seq
                                                                                                        • FS847_01995
                                                                                                        • TXD00266.1
                                                                                                        		 554476 - 566334 (-) SDR family NAD(P)-dependent oxidoreductase
                                                                                                          copy AA seq
                                                                                                          copy Nt seq
                                                                                                          • FS847_02000
                                                                                                          • TXD00027.1
                                                                                                          		 566750 - 567886 (+) molybdopterin-dependent oxidoreductase
                                                                                                            copy AA seq
                                                                                                            copy Nt seq
                                                                                                            • FS847_02005
                                                                                                            • TXD00028.1
                                                                                                            		 567883 - 568284 (+) hypothetical protein
                                                                                                              copy AA seq
                                                                                                              copy Nt seq
                                                                                                              • FS847_02010
                                                                                                              • TXD00029.1
                                                                                                              		 568339 - 569355 (-) NADP-dependent oxidoreductase
                                                                                                                copy AA seq
                                                                                                                copy Nt seq
                                                                                                                • FS847_02015
                                                                                                                • TXD00030.1
                                                                                                                		 569469 - 570455 (+) helix-turn-helix domain-containing protein
                                                                                                                  copy AA seq
                                                                                                                  copy Nt seq
                                                                                                                  • FS847_02020
                                                                                                                  • TXD00031.1
                                                                                                                  		 570516 - 573722 (-) cytochrome P450
                                                                                                                    copy AA seq
                                                                                                                    copy Nt seq
                                                                                                                    • FS847_02025
                                                                                                                    • TXD00032.1
                                                                                                                    		 573860 - 574510 (+) TetR family transcriptional regulator
                                                                                                                      copy AA seq
                                                                                                                      copy Nt seq
                                                                                                                      • FS847_02030
                                                                                                                      • TXD00033.1
                                                                                                                      		 574690 - 589527 (-) SDR family NAD(P)-dependent oxidoreductase
                                                                                                                        copy AA seq
                                                                                                                        copy Nt seq
                                                                                                                        • FS847_02035
                                                                                                                        • TXD00034.1
                                                                                                                        		 589574 - 602305 (-) SDR family NAD(P)-dependent oxidoreductase
                                                                                                                          copy AA seq
                                                                                                                          copy Nt seq
                                                                                                                          • FS847_02040
                                                                                                                          • TXD00267.1
                                                                                                                          		 602669 - 604081 (+) NDP-hexose 2,3-dehydratase
                                                                                                                            copy AA seq
                                                                                                                            copy Nt seq
                                                                                                                            • FS847_02045
                                                                                                                            • TXD00035.1
                                                                                                                            		 604261 - 604905 (-) TetR family transcriptional regulator
                                                                                                                              copy AA seq
                                                                                                                              copy Nt seq
                                                                                                                              • FS847_02050
                                                                                                                              • TXD00036.1
                                                                                                                              		 604932 - 605705 (-) FadR family transcriptional regulator
                                                                                                                                copy AA seq
                                                                                                                                copy Nt seq
                                                                                                                                • FS847_02055
                                                                                                                                • TXD00037.1
                                                                                                                                		 606743 - 609562 (+) AAA family ATPase
                                                                                                                                  copy AA seq
                                                                                                                                  copy Nt seq
                                                                                                                                  • FS847_02060
                                                                                                                                  • TXD00038.1
                                                                                                                                  		 610016 - 610756 (+) LuxR family transcriptional regulator
                                                                                                                                    copy AA seq
                                                                                                                                    copy Nt seq
                                                                                                                                    • FS847_02065
                                                                                                                                    • TXD00039.1
                                                                                                                                    		 611446 - 614667 (+) AAA family ATPase
                                                                                                                                      copy AA seq
                                                                                                                                      copy Nt seq
                                                                                                                                      • FS847_02070
                                                                                                                                      • TXD00040.1
                                                                                                                                      		 614763 - 615479 (-) 4'-phosphopantetheinyl transferase superfamily protein
                                                                                                                                        copy AA seq
                                                                                                                                        copy Nt seq
                                                                                                                                        • FS847_02075
                                                                                                                                        • TXD00041.1
                                                                                                                                        		 615852 - 616070 (+) hypothetical protein
                                                                                                                                          copy AA seq
                                                                                                                                          copy Nt seq
                                                                                                                                          • FS847_02080
                                                                                                                                          • TXD00042.1
                                                                                                                                          		 616409 - 616909 (+) hypothetical protein
                                                                                                                                            copy AA seq
                                                                                                                                            copy Nt seq
                                                                                                                                            • FS847_02085
                                                                                                                                            • TXD00268.1
                                                                                                                                            		 617637 - 618116 (+) hypothetical protein
                                                                                                                                              copy AA seq
                                                                                                                                              copy Nt seq
                                                                                                                                              • FS847_02090
                                                                                                                                              • TXD00043.1
                                                                                                                                              		 618113 - 619396 (+) HAMP domain-containing histidine kinase
                                                                                                                                                copy AA seq
                                                                                                                                                copy Nt seq
                                                                                                                                                • FS847_02095
                                                                                                                                                • TXD00044.1
                                                                                                                                                		 619601 - 621685 (+) SpoIIE family protein phosphatase
                                                                                                                                                  copy AA seq
                                                                                                                                                  copy Nt seq
                                                                                                                                                  Biosynthesis information

                                                                                                                                                  No biosynthesis information available for this record.

                                                                                                                                                  Annotation changelog

                                                                                                                                                  Entry version: 3

                                                                                                                                                  Date
                                                                                                                                                  Changes
                                                                                                                                                  Submitters
                                                                                                                                                  Reviewers
                                                                                                                                                  2022-10-07
                                                                                                                                                  Update chemical activity to schema version 2.11
                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                  Entry version: 2

                                                                                                                                                  Date
                                                                                                                                                  Changes
                                                                                                                                                  Submitters
                                                                                                                                                  Reviewers
                                                                                                                                                  2022-09-15
                                                                                                                                                  Updated bioactivity data
                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                  Entry version: 1

                                                                                                                                                  Date
                                                                                                                                                  Changes
                                                                                                                                                  Submitters
                                                                                                                                                  Reviewers
                                                                                                                                                  2019-10-16
                                                                                                                                                  Submitted
                                                                                                                                                  • (ID: D573CRWGF3Z73VN2NY3DHI3L)
                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                  Similar known clusters from MIBiG 4.0
                                                                                                                                                  Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                                                                                                  Detailed help and explanations are available here.

                                                                                                                                                  Click on reference genes to show details of similarities to genes within the current region.
                                                                                                                                                  Double click on a reference drawing to reverse the display of the genes.

                                                                                                                                                  Click on an accession to open that entry in the MIBiG database.


                                                                                                                                                  Location:

                                                                                                                                                  Identifier
                                                                                                                                                  Identity
                                                                                                                                                  Coverage
                                                                                                                                                  Detailed domain annotation
                                                                                                                                                  Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                                                                                                  A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                                                                                                  Selected features only
                                                                                                                                                  Show module domains