BGC0001919: neoantimycin biosynthetic gene cluster from Streptomyces orinoci
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Location: 1 - 42,361 nt. (total: 42,361 nt).
This entry is originally from NCBI GenBank LC375136.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001919
Short description neoantimycin biosynthetic gene cluster from Streptomyces orinoci
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: LC375136.1
Compounds
  • neoantimycin
Species Streptomyces orinoci [taxonomy]
References
Chemical products information
neoantimycin
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C36H46N2O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BBD17757.1
 1 - 1368 (-) hypothetical protein
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  • BBD17758.1
  • natA
 1510 - 2037 (-) sigma factor
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  • BBD17759.1
  • natB
 2484 - 16343 (+) non-ribosomal peptide synthetase
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  • BBD17760.1
  • natC
 16336 - 20571 (+) polyketide synthase
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  • BBD17761.1
  • natD
 20656 - 27867 (+) non-ribosomal peptide synthetase
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  • BBD17762.1
  • natE
 27864 - 28061 (+) mbtH
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  • BBD17763.1
  • natF
 28058 - 29086 (+) NAD-dependent reductase
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  • BBD17764.1
  • natG
 29083 - 29850 (+) thioesterase
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  • BBD17765.1
  • natH
 29813 - 30508 (-) 4'-phosphopantetheinyl transferase
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  • BBD17766.1
  • natI
 30513 - 32000 (-) AMP-ligase
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  • BBD17767.1
  • natJ
 32000 - 32221 (-) acyl carrier protein
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  • BBD17768.1
  • natK
 32469 - 33470 (+) epoxidase component
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  • BBD17769.1
  • natL
 33467 - 33760 (+) epoxidase component
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  • BBD17770.1
  • natM
 33747 - 34502 (+) epoxidase component
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  • BBD17771.1
  • natN
 34499 - 34996 (+) epoxidase component
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  • BBD17772.1
  • natO
 35004 - 36104 (+) epoxidase component
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  • BBD17773.1
  • natP
 36215 - 37027 (+) tryptophan dioxygenase
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  • BBD17774.1
  • natQ
 37020 - 37844 (+) kynurenine formamidase
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  • BBD17775.1
  • natR
 37847 - 39097 (+) kynureninase
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  • BBD17776.1
 39340 - 41106 (-) phosphoesterase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
natB
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Homology
  • Heterologous expression
natI
Module ?
Specificity: anthanillic acid
Evidence for specificity:
  • Structure-based inference
  • Homology
  • Heterologous expression
Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
  • Fetch compound properties from PubChem
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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