BGC0001953: puwainaphycin F biosynthetic gene cluster from Anabaena sp. UHCC-0399
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Location: 1 - 60,901 nt. (total: 60,901 nt).
This entry is originally from NCBI GenBank MH325200.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001953
Short description puwainaphycin F biosynthetic gene cluster from Anabaena sp. UHCC-0399
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MH325200.1
via
Compounds
  • puwainaphycin F
  • minutissamide A
  • minutissamide B
  • minutissamide C
  • minutissamide D
Species Anabaena sp. UHCC-0399 [taxonomy]
References
Chemical products information
puwainaphycin F Evidence:
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C51H82Cl1N13O15
Chemical database entries
PubCHEM
minutissamide A Evidence:
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C55H89N13O16
Chemical database entries
PubCHEM
minutissamide B Evidence:
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C55H91N13O16
Chemical database entries
PubCHEM
minutissamide C Evidence:
(no structure information available)
minutissamide D Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AXN93605.1
  • puwA
 1 - 8565 (-) PuwA
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    • AXN93606.1
    • orf2
    		 8971 - 10902 (-) ORF2
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      • AXN93607.1
      • orf3
      		 12352 - 14442 (+) ORF3
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        • AXN93608.1
        • puwI
        		 14989 - 17133 (+) PuwI
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          • AXN93609.1
          • puwJ
          		 17136 - 18419 (+) PuwJ
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            • AXN93610.1
            • puwB
            		 18459 - 26108 (+) PuwB
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              • AXN93611.1
              • puwc
              		 26420 - 27898 (+) PuwC
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                • AXN93612.1
                • puwD
                		 27975 - 28256 (+) PuwD
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                  • AXN93613.1
                  • puwE
                  		 28358 - 37657 (+) PuwE
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                    • AXN93614.1
                    • puwF
                    		 37654 - 46308 (+) PuwF
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                      • AXN93615.1
                      • puwG
                      		 46346 - 55273 (+) PuwG
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                        • AXN93616.1
                        • puwH
                        		 55344 - 58709 (+) PuwH
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                          • AXN93617.1
                          • orf1
                          		 58970 - 60901 (+) ORF1
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            Unk01
                            Type
                            nrps-type1
                            Genes
                            puwA
                            Substrates
                            asparagine (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk02
                            Type
                            nrps-type1
                            Genes
                            puwA
                            Substrates
                            proline (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk03
                            Type
                            nrps-type1
                            Genes
                            puwE
                            Substrates
                            valine (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk04
                            Type
                            nrps-type1
                            Genes
                            puwF
                            Substrates
                            threonine (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk05
                            Type
                            nrps-type1
                            Genes
                            puwF
                            Substrates
                            asparagine, threonine (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk06
                            Type
                            nrps-type1
                            Genes
                            puwG
                            Substrates
                            asparagine (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk07
                            Type
                            nrps-type1
                            Genes
                            puwG
                            Substrates
                            alanine, glycine, serine (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk08
                            Type
                            nrps-type1
                            Genes
                            puwH
                            Substrates
                            threonine (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Annotation changelog

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Cleaned up synonym list
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Fetch compound properties from PubChem
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Updated bioactivity data
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Added NRP substrate specificities
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Submitted
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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