BGC0001966: BII-rafflesfungin biosynthetic gene cluster from Phoma sp.
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Location: 1 - 84,810 nt. (total: 84,810 nt).
This entry is originally from NCBI GenBank MK043052.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001966
Short description BII-rafflesfungin biosynthetic gene cluster from Phoma sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
MK043052.1
via
Compounds
  • BII-rafflesfungin
Species Phoma sp. [taxonomy]
References
Chemical products information
BII-rafflesfungin Evidence: NMR [1], MS/MS [1]
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C44H75N9O17
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QCC62988.1
 1 - 1007 (-) putative heme-binding protein
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    • QCC62989.1
    		 3190 - 8187 (-) hypothetical protein
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      • QCC62990.1
      		 9161 - 11198 (-) AMP dependent ligase
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        • QCC62991.1
        		 13156 - 16779 (+) glycosyltransferase
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          • QCC62992.1
          		 18186 - 19814 (+) putative membrane transport protein
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            • QCC62993.1
            		 21053 - 21615 (+) MARVEL domain containing protein
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              • QCC62994.1
              		 23736 - 24448 (-) heme oxygenase-like protein
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                • QCC62995.1
                		 28062 - 29788 (-) FAD-binding domain-containing protein
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                  • QCC62996.1
                  		 32463 - 33223 (+) hypothetical protein
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                    • QCC62997.1
                    		 35907 - 36919 (-) hypothetical protein
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                      • QCC62998.1
                      		 38724 - 39576 (-) thioesterase type II domain containing protein
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                        • QCC62999.1
                        		 42561 - 74741 (-) BII-rafflesfungin nonribosomal protein synthetase
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                          • QCC63000.1
                          		 76706 - 84810 (+) BII-rafflesfungin polyketide synthase
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            Unk01
                            Type
                            nrps-type1
                            Genes
                            QCC62999.1
                            Substrates
                            alanine (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk02
                            Type
                            nrps-type1
                            Genes
                            QCC62999.1
                            Substrates
                            glutamic acid (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk03
                            Type
                            nrps-type1
                            Genes
                            QCC62999.1
                            Substrates
                            asparagine (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk04
                            Type
                            nrps-type1
                            Genes
                            QCC62999.1
                            Substrates
                            serine (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk05
                            Type
                            nrps-type1
                            Genes
                            QCC62999.1
                            Substrates
                            serine (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk06
                            Type
                            nrps-type1
                            Genes
                            QCC62999.1
                            Substrates
                            serine (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk07
                            Type
                            nrps-type1
                            Genes
                            QCC62999.1
                            Substrates
                            threonine (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk08
                            Type
                            nrps-type1
                            Genes
                            QCC62999.1
                            Substrates
                            glycine (evidence: Structure-based inference, Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            adenylation
                            Annotation changelog

                            Entry version: next

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2024-05-14
                            MIBiG v4 annotathon
                            • (ID: 5SRAIADCX5E626OGO7LYHFZD)
                            • (ID: 4B6CAZ6GBFQV2DK75DYGLHB6)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Added missing polyketide class
                            • (ID: CUSGWVK3I4TVHJH7NHPFAP2L)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Added NRP substrate specificities
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Submitted
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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