BGC0002014: pepticinnamin E biosynthetic gene cluster from Actinobacteria bacterium OK006
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Location: 83,289 - 164,807 nt. (total: 81,519 nt).
This entry is originally from NCBI GenBank NZ_LJCU01000236.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002014
Short description pepticinnamin E biosynthetic gene cluster from Actinobacteria bacterium OK006
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
NZ_LJCU01000236.1
101713 - 146406
via
Compounds
  • pepticinnamin E
Species Actinobacteria bacterium OK006 [taxonomy]
References
Chemical products information
pepticinnamin E [synonyms: Pepticinnamine E] Evidence:
Copy SMILES
C49H54Cl1N5O10
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • OK006_RS36460
  • WP_082417547.1
 101713 - 103281 (-) tryptophan 7-halogenase
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    • OK006_RS36465
    • WP_054234617.1
    		 103289 - 110821 (-) non-ribosomal peptide synthetase
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      • OK006_RS36470
      • WP_054234618.1
      		 110864 - 111067 (-) MbtH family protein
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        • OK006_RS36475
        • WP_054234619.1
        		 111378 - 111821 (+) enediyne antibiotic chromoprotein
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          • OK006_RS36480
          • WP_054234620.1
          		 111950 - 112753 (-) ABC transporter permease
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            • OK006_RS36485
            • WP_054234621.1
            		 112750 - 113736 (-) ATP-binding cassette domain-containing protein
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              • OK006_RS36490
              • WP_054234622.1
              		 113902 - 115143 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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                • OK006_RS36495
                • WP_054234623.1
                		 115140 - 116216 (+) beta-ketoacyl synthase N-terminal-like domain-containing protein
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                  • OK006_RS36500
                  • WP_054234624.1
                  		 116213 - 117925 (+) NAD(P)/FAD-dependent oxidoreductase
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                    • OK006_RS36505
                    • WP_054234625.1
                    		 117948 - 118610 (-) class I SAM-dependent methyltransferase
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                      • OK006_RS36510
                      • WP_054234626.1
                      		 118648 - 119406 (-) hypothetical protein
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                        • OK006_RS36515
                        • WP_054234627.1
                        		 119679 - 119936 (+) acyl carrier protein
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                          • OK006_RS36520
                          • WP_054234628.1
                          		 119967 - 121193 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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                            • OK006_RS36525
                            • WP_054234629.1
                            		 121190 - 122332 (+) beta-ketoacyl synthase N-terminal-like domain-containing protein
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                              • OK006_RS36530
                              • WP_054234630.1
                              		 122329 - 123327 (+) beta-ketoacyl synthase N-terminal-like domain-containing protein
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                                • OK006_RS36535
                                • WP_082417543.1
                                		 123324 - 124211 (+) alpha/beta hydrolase
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                                  • OK006_RS36540
                                  • WP_054234632.1
                                  		 124211 - 125221 (+) hypothetical protein
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                                    • OK006_RS36545
                                    • WP_054234633.1
                                    		 125218 - 126261 (+) beta-ketoacyl synthase N-terminal-like domain-containing protein
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                                      • OK006_RS36550
                                      • WP_054234634.1
                                      		 126346 - 127092 (+) 3-oxoacyl-ACP reductase FabG
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                                        • OK006_RS36555
                                        • WP_054234635.1
                                        		 127120 - 127836 (+) DsbA family protein
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                                          • OK006_RS36560
                                          • WP_054234636.1
                                          		 127878 - 128135 (+) acyl carrier protein
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                                            • OK006_RS36565
                                            • WP_054234637.1
                                            		 128132 - 128467 (+) hypothetical protein
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                                              • OK006_RS36570
                                              • WP_054234638.1
                                              		 128470 - 128883 (+) DsrE family protein
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                                                • OK006_RS58490
                                                • WP_054234639.1
                                                		 128884 - 129267 (+) DsrE family protein
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                                                  • OK006_RS58495
                                                  • WP_054234640.1
                                                  		 129264 - 129713 (+) hypothetical protein
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                                                    • OK006_RS36585
                                                    • WP_067733580.1
                                                    		 129710 - 130249 (+) hypothetical protein
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                                                      • OK006_RS36590
                                                      • WP_054234641.1
                                                      		 130267 - 131589 (-) NB-ARC domain-containing protein
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                                                        • OK006_RS36595
                                                        • WP_097286309.1
                                                        		 131730 - 132224 (-) DUF3995 domain-containing protein
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                                                          • OK006_RS36600
                                                          • WP_159055335.1
                                                          		 132542 - 132943 (-) DUF6191 domain-containing protein
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                                                            • OK006_RS36605
                                                            • WP_054234643.1
                                                            		 133375 - 144807 (+) non-ribosomal peptide synthetase
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                                                              • OK006_RS36610
                                                              • WP_054234644.1
                                                              		 145063 - 146406 (+) cation:proton antiporter
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                                                                Biosynthesis information

                                                                Biosynthetic modules

                                                                Name
                                                                Unk01
                                                                Type
                                                                nrps-type1
                                                                Genes
                                                                OK006_RS36465
                                                                Substrates
                                                                tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                                Integrated Monomers
                                                                Domains
                                                                adenylation
                                                                Name
                                                                Unk02
                                                                Type
                                                                nrps-type1
                                                                Genes
                                                                OK006_RS36465
                                                                Substrates
                                                                tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                                Integrated Monomers
                                                                Domains
                                                                adenylation
                                                                Name
                                                                Unk03
                                                                Type
                                                                nrps-type1
                                                                Genes
                                                                OK006_RS36605
                                                                Substrates
                                                                phenylalanine (evidence: Structure-based inference, Sequence-based prediction)
                                                                Integrated Monomers
                                                                Domains
                                                                adenylation
                                                                Name
                                                                Unk04
                                                                Type
                                                                nrps-type1
                                                                Genes
                                                                OK006_RS36605
                                                                Substrates
                                                                serine (evidence: Structure-based inference, Sequence-based prediction)
                                                                Integrated Monomers
                                                                Domains
                                                                adenylation
                                                                Name
                                                                Unk05
                                                                Type
                                                                nrps-type1
                                                                Genes
                                                                OK006_RS36605
                                                                Substrates
                                                                glycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                Integrated Monomers
                                                                Domains
                                                                adenylation
                                                                Annotation changelog

                                                                Entry version: 3

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2024-08-09
                                                                MIBiG v4 annotathon
                                                                • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 2

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2022-09-15
                                                                Cleaned up synonym list
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                2022-09-15
                                                                Fetch compound properties from PubChem
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                2022-09-15
                                                                Added NRP substrate specificities
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 1

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2019-10-16
                                                                Submitted
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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