BGC0002033: spiramycin biosynthetic gene cluster from Streptomyces ambofaciens ATCC 23877
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Location: 5,967,886 - 6,057,980 nt. (total: 90,095 nt).
This entry is originally from NCBI GenBank NZ_CP012382.1.

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core biosynthetic genes
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Gene details
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General
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0002033
Short description spiramycin biosynthetic gene cluster from Streptomyces ambofaciens ATCC 23877
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: NZ_CP012382.1
Compounds
  • spiramycin
Species Streptomyces ambofaciens ATCC 23877 [taxonomy]
References
Chemical products information
spiramycin
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C43H74N2O14
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SAM23877_RS26565
  • WP_053138380.1
 5967886 - 5969310 (+) ricin-type beta-trefoil lectin domain protein
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  • SAM23877_RS26570
  • WP_053142886.1
 5969372 - 5969599 (-) DUF3253 domain-containing protein
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  • SAM23877_RS26575
  • WP_053138398.1
 5969721 - 5971232 (+) PLP-dependent aminotransferase family protein
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  • SAM23877_RS26580
  • WP_053138404.1
 5971481 - 5972455 (-) aldo/keto reductase
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  • SAM23877_RS26585
  • WP_063796824.1
 5972675 - 5973523 (+) NAD(P)H-binding protein
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  • SAM23877_RS26590
  • WP_079030445.1
 5973546 - 5974553 (-) glycosyl hydrolase
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  • SAM23877_RS26595
  • WP_053138412.1
 5975242 - 5976405 (+) transposase
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  • SAM23877_RS26600
  • WP_053138415.1
 5976669 - 5977289 (-) dTDP-4-dehydrorhamnose 3,5-epimerase family protein
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  • SAM23877_RS26605
  • WP_063483317.1
 5977339 - 5978556 (-) hypothetical protein
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  • SAM23877_RS26610
  • WP_107291978.1
 5978857 - 5979672 (+) 3-hydroxyacyl-CoA dehydrogenase family protein
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  • SAM23877_RS26615
  • WP_053138424.1
 5979669 - 5979980 (+) acyl carrier protein
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  • SAM23877_RS26620
  • WP_053138427.1
 5979973 - 5981094 (+) acyl-CoA dehydrogenase family protein
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  • SAM23877_RS26625
  • WP_053138430.1
 5981183 - 5982298 (+) HAD-IIIC family phosphatase
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  • SAM23877_RS26630
  • WP_053138433.1
 5982295 - 5983527 (+) class I SAM-dependent methyltransferase
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  • SAM23877_RS26635
  • WP_053138436.1
 5983570 - 5984577 (-) aldo/keto reductase
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  • SAM23877_RS26640
  • WP_235614616.1
 5984574 - 5985566 (-) NAD(P)-dependent oxidoreductase
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  • SAM23877_RS26645
  • WP_053138443.1
 5985568 - 5986746 (-) DUF1205 domain-containing protein
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  • SAM23877_RS26650
  • WP_053138447.1
 5986863 - 5988134 (-) activator-dependent family glycosyltransferase
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  • SAM23877_RS26655
  • WP_053138450.1
 5988191 - 5989429 (-) P450-derived glycosyltransferase activator
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  • SAM23877_RS26660
  • WP_079030446.1
 5989742 - 5990782 (+) Gfo/Idh/MocA family oxidoreductase
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  • SAM23877_RS26665
  • WP_053138455.1
 5990891 - 5991934 (-) hypothetical protein
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  • SAM23877_RS26670
  • WP_079030798.1
  • hflX
 5992254 - 5993651 (+) GTPase HflX
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  • SAM23877_RS26675
  • WP_053138458.1
  • rfbH
 5993715 - 5995016 (-) lipopolysaccharide biosynthesis protein RfbH
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  • SAM23877_RS26680
  • WP_053138477.1
 5995360 - 5997012 (+) ABC-F type ribosomal protection protein Srm(B)
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  • SAM23877_RS26685
  • WP_053138480.1
 5997123 - 5999090 (-) helix-turn-helix domain-containing protein
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  • SAM23877_RS26690
  • WP_053138489.1
 5999665 - 6000384 (+) class I SAM-dependent methyltransferase
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  • SAM23877_RS26695
  • WP_053138492.1
 6000512 - 6001660 (-) DegT/DnrJ/EryC1/StrS family aminotransferase
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  • SAM23877_RS26700
  • WP_053142891.1
 6002065 - 6003474 (-) NDP-hexose 2,3-dehydratase family protein
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  • SAM23877_RS26705
  • WP_053142893.1
 6003476 - 6004279 (-) alpha/beta fold hydrolase
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  • SAM23877_RS26710
  • WP_053142895.1
  • rfbB
 6004276 - 6005247 (-) dTDP-glucose 4,6-dehydratase
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  • SAM23877_RS26715
  • WP_053138495.1
  • rfbA
 6005297 - 6006175 (-) glucose-1-phosphate thymidylyltransferase RfbA
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  • SAM23877_RS26720
  • WP_053138498.1
 6006202 - 6007368 (-) DegT/DnrJ/EryC1/StrS family aminotransferase
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  • SAM23877_RS26725
  • WP_235614617.1
 6007365 - 6007715 (-) FdtA/QdtA family cupin domain-containing protein
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  • SAM23877_RS26730
  • WP_053138501.1
 6007901 - 6009112 (-) cytochrome P450
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  • SAM23877_RS39245
  • WP_053138504.1
 6009659 - 6023317 (+) type I polyketide synthase
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  • SAM23877_RS37920
  • WP_079030450.1
 6023361 - 6029351 (+) type I polyketide synthase
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  • SAM23877_RS26760
  • WP_159041997.1
 6029425 - 6040599 (+) SDR family NAD(P)-dependent oxidoreductase
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  • SAM23877_RS26765
  • WP_053138519.1
 6040644 - 6045386 (+) type I polyketide synthase
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  • SAM23877_RS26770
  • WP_053138522.1
 6045482 - 6051145 (+) type I polyketide synthase
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  • SAM23877_RS26775
  • WP_053138527.1
 6051145 - 6051855 (+) class I SAM-dependent methyltransferase
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  • SAM23877_RS26780
  • WP_053138530.1
 6051975 - 6053246 (+) P450-derived glycosyltransferase activator
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  • SAM23877_RS26785
  • WP_053138533.1
 6053286 - 6054551 (+) activator-dependent family glycosyltransferase
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  • SAM23877_RS26790
  • WP_053138536.1
  • ccrA
 6054578 - 6055927 (+) crotonyl-CoA carboxylase/reductase
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  • SAM23877_RS26795
  • WP_053142901.1
 6056065 - 6056730 (-) class I SAM-dependent methyltransferase
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  • SAM23877_RS26800
  • WP_053138539.1
 6056736 - 6057980 (-) acyltransferase
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Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
  • Fetch compound properties from PubChem
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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