BGC0002048: endopyrrole B biosynthetic gene cluster from Mycetohabitans rhizoxinica HKI 454
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Location: 1,815,672 - 1,881,846 nt. (total: 66,175 nt).
This entry is originally from NCBI GenBank FR687359.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002048
Short description endopyrrole B biosynthetic gene cluster from Mycetohabitans rhizoxinica HKI 454
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
FR687359.1
1835600 - 1866150
via Knock-out studies
Compounds
  • endopyrrole B
  • endopyrrole A
Species Mycetohabitans rhizoxinica HKI 454 [taxonomy]
References
Chemical products information
endopyrrole B Evidence: NMR, Mass spectrometry
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C41H60N8O12
Chemical database entries
NPAtlas
endopyrrole A Evidence: NMR, Mass spectrometry, Chemical derivatisation
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C50H67N9O13
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RBRH_03984
  • CBW75451.1
 1835672 - 1846288 (-) Non-ribosomal peptide synthetase modules
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    • RBRH_04313
    • CBW75452.1
    		 1846246 - 1853268 (-) Non-ribosomal peptide synthetase modules (EC 6.3.2.-)
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      • RBRH_03867
      • CBW75453.1
      		 1853249 - 1861846 (-) Non-ribosomal peptide synthetase modules (EC 6.3.2.-)
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        • RBRH_03865
        • CBW75454.1
        		 1862930 - 1863286 (+)
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          • RBRH_03864
          • CBW75455.1
          		 1863283 - 1864887 (+) D-alanine-activating enzyme (EC 6.3.2.-)
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            • RBRH_03863
            • CBW75456.1
            		 1864871 - 1866016 (+) Isovaleryl-CoA dehydrogenase (EC 1.3.99.10)
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              Biosynthesis information

              Biosynthetic modules

              Name
              0
              Type
              nrps-type1
              Genes
              RBRH_03864
              Substrates
              pyrrole-2-carboxylic acid (evidence: Structure-based inference [1])
              Integrated Monomers
              Domains
              adenylation
              Name
              1
              Type
              nrps-type1
              Genes
              RBRH_03867
              Substrates
              valine (evidence: Structure-based inference [1])
              Integrated Monomers
              Domains
              condensation (Starter), adenylation
              Name
              2
              Type
              nrps-type1
              Genes
              RBRH_03867
              Substrates
              proline (evidence: Structure-based inference [1])
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              3
              Type
              nrps-type1
              Genes
              RBRH_03867
              Substrates
              valine (evidence: Structure-based inference [1])
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              4
              Type
              nrps-type1
              Genes
              RBRH_04313
              Substrates
              valine (evidence: Structure-based inference [1])
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              5
              Type
              nrps-type1
              Genes
              RBRH_04313
              Substrates
              threonine (evidence: Structure-based inference [1])
              Integrated Monomers
              Domains
              condensation (Dual), adenylation
              Name
              6
              Type
              nrps-type1
              Genes
              RBRH_03984
              Substrates
              serine (evidence: Structure-based inference [1])
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              7
              Type
              nrps-type1
              Genes
              RBRH_03984
              Substrates
              tyrosine (evidence: Structure-based inference [1])
              Integrated Monomers
              Domains
              condensation (Dual), adenylation
              Name
              8
              Type
              nrps-type1
              Genes
              RBRH_03984
              Substrates
              tyrosine (evidence: Structure-based inference [1])
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Annotation changelog

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              2022-10-07
              Changed chemical structures for compounds: endopyrrole B, endopyrrole A.
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-10-07
              Added NPAtlas links to compounds: endopyrrole B, endopyrrole A.
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2022-09-15
              Submitted
              • (ID: Z7AIIJAM3U3HR6IYDPQOINM4)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Corrected NRP module activity
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Added version to NCBI accession
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Updated NRP substrate specificities
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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