BGC0002083: gladiofungin A biosynthetic gene cluster from Burkholderia gladioli
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Location: 1,136,002 - 1,222,022 nt. (total: 86,021 nt).
This entry is originally from NCBI GenBank WITE01000004.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002083
Short description gladiofungin A biosynthetic gene cluster from Burkholderia gladioli
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Trans-AT type I)
Loci
WITE01000004.1
1150314 - 1205481
via Knock-out studies
Compounds
  • gladiofungin A
  • gladiofungin B
Species Burkholderia gladioli [taxonomy]
References
Chemical products information
gladiofungin A Evidence: NMR, Mass spectrometry
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C27H39N1O8
Chemical database entries
NPAtlas
gladiofungin B Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • LvStA_05063
  • KAF1058468.1
 1148980 - 1150314 (-) hypothetical protein
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    • LvStA_05064
    • KAF1058469.1
    • aldA_1
    		 1150362 - 1151879 (-) putative aldehyde dehydrogenase AldA
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      • LvStA_05065
      • KAF1058470.1
      		 1151949 - 1152821 (-) 2-(hydroxymethyl)glutarate dehydrogenase
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        • LvStA_05066
        • KAF1058471.1
        • cmpR_9
        		 1152965 - 1153873 (+) HTH-type transcriptional activator CmpR
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          • LvStA_05067
          • KAF1058472.1
          • yfmJ
          		 1154171 - 1155193 (-) putative NADP-dependent oxidoreductase YfmJ
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            • LvStA_05068
            • KAF1058473.1
            		 1155228 - 1155941 (-) hypothetical protein
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              • LvStA_05069
              • KAF1058474.1
              • pksN_1
              		 1156002 - 1186547 (-) Polyketide synthase PksN
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                • LvStA_05070
                • KAF1058475.1
                • pksL_1
                		 1186548 - 1196294 (-) Polyketide synthase PksL
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                  • LvStA_05071
                  • KAF1058476.1
                  • asnB_1
                  		 1196287 - 1198284 (-) Asparagine synthetase [glutamine-hydrolyzing] 1
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                    • LvStA_05072
                    • KAF1058477.1
                    • dltC
                    		 1198379 - 1198621 (-) D-alanine--poly(phosphoribitol) ligase subunit 2
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                      • LvStA_05073
                      • KAF1058478.1
                      • baeE_1
                      		 1198663 - 1202022 (-) Polyketide biosynthesis protein BaeE
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                        • LvStA_05074
                        • KAF1058479.1
                        		 1202098 - 1202799 (-) hypothetical protein
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                          • LvStA_05075
                          • KAF1058480.1
                          		 1204551 - 1205270 (+) hypothetical protein
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                            • LvStA_05076
                            • KAF1058481.1
                            • naiP_1
                            		 1205481 - 1206743 (-) putative niacin/nicotinamide transporter NaiP
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              0
                              Type
                              pks-modular-starter
                              Genes
                              baeE_1
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, enoylreductase
                              Name
                              1
                              Type
                              pks-trans-at
                              Genes
                              pksL_1
                              Substrates
                              Integrated Monomers
                              Domains
                              ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                              Name
                              2
                              Type
                              pks-trans-at
                              Genes
                              pksL_1
                              Substrates
                              Integrated Monomers
                              Domains
                              ketosynthase, branching, branching, carrier (ACP)
                              Name
                              3
                              Type
                              pks-trans-at
                              Genes
                              pksL_1 pksN_1
                              Substrates
                              Integrated Monomers
                              Domains
                              ketosynthase, ketoreductase, carrier (ACP)
                              Name
                              4
                              Type
                              pks-trans-at
                              Genes
                              pksN_1
                              Substrates
                              Integrated Monomers
                              Domains
                              ketosynthase, carrier (ACP)
                              Name
                              5
                              Type
                              pks-trans-at
                              Genes
                              pksN_1
                              Substrates
                              Integrated Monomers
                              Domains
                              ketosynthase, dehydratase, ketoreductase, methyltransferase, methyltransferase, carrier (ACP), carrier (ACP)
                              Name
                              6
                              Type
                              pks-trans-at
                              Genes
                              pksN_1
                              Substrates
                              Integrated Monomers
                              Domains
                              ketosynthase, dehydratase, carrier (ACP)
                              Name
                              7
                              Type
                              pks-trans-at
                              Genes
                              pksN_1
                              Substrates
                              Integrated Monomers
                              Domains
                              ketosynthase, ketoreductase, carrier (ACP), carrier (ACP), carrier (ACP)
                              Name
                              8
                              Type
                              pks-trans-at
                              Genes
                              pksN_1
                              Substrates
                              Integrated Monomers
                              Domains
                              ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                              Name
                              9
                              Type
                              pks-trans-at
                              Genes
                              pksN_1
                              Substrates
                              Integrated Monomers
                              Domains
                              ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                              Name
                              10
                              Type
                              pks-trans-at
                              Genes
                              pksN_1
                              Substrates
                              Integrated Monomers
                              Domains
                              ketosynthase, other (A-factor synthase A)
                              Annotation changelog

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-10-07
                              Changed chemical structures for compounds: gladiofungin A.
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-10-07
                              Added chemical structures for compounds: gladiofungin B.
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-10-07
                              Added NPAtlas links to compounds: gladiofungin B.
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Submitted
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Merged cross-CDS PKS modules
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Sorted modules by module number
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Added version to NCBI accession
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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