BGC0002097: kosinostatin biosynthetic gene cluster from Micromonospora sp. 28ISP2-46
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Location: 5,656,833 - 5,729,306 nt. (total: 72,474 nt).
This entry is originally from NCBI GenBank CP059322.1.

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core biosynthetic genes
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002097
Short description kosinostatin biosynthetic gene cluster from Micromonospora sp. 28ISP2-46
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "We rediscovered kosinostatin from a Micromonospora strain and identified the BGC in its genome sequence based on homology to the previously published BGC (antiSMASH). Certain genes thought to be important to kosinostatin biosynthesis are missing from our cluster."
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type II)
  • saccharide (hybrid/tailoring)
Loci
CP059322.1
5660056 - 5708619
via
Compounds
  • kosinostatin
Species Micromonospora sp. 28ISP2-46 [taxonomy]
References
Chemical products information
kosinostatin Evidence: NMR
(no structure information available)
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • H1D33_25545
  • QLQ36600.1
 5660056 - 5661471 (-) UbiD family decarboxylase
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    • H1D33_25550
    • QLQ40534.1
    		 5661468 - 5662160 (-) transglutaminase domain-containing protein
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      • H1D33_25555
      • QLQ36601.1
      		 5662199 - 5663059 (-) methyltransferase domain-containing protein
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        • H1D33_25560
        • QLQ36602.1
        		 5663255 - 5664757 (+) FAD-binding oxidoreductase
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          • H1D33_25565
          • QLQ40535.1
          		 5664799 - 5665869 (+) beta-lactamase family protein
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            • H1D33_25570
            • QLQ36603.1
            		 5666004 - 5666441 (+) Ohr family peroxiredoxin
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              • H1D33_25575
              • QLQ36604.1
              		 5666454 - 5667257 (-) TetR/AcrR family transcriptional regulator
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                • H1D33_25580
                • QLQ36605.1
                		 5667340 - 5668176 (-) NAD(P)H-binding protein
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                  • H1D33_25585
                  • QLQ36606.1
                  		 5668310 - 5668765 (+) ester cyclase
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                    • H1D33_25590
                    • QLQ36607.1
                    		 5668768 - 5669811 (+) zinc-binding dehydrogenase
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                      • H1D33_25595
                      • QLQ36608.1
                      		 5669882 - 5670865 (+) Gfo/Idh/MocA family oxidoreductase
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                        • H1D33_25600
                        • QLQ36609.1
                        		 5670930 - 5672231 (-) hypothetical protein
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                          • H1D33_25605
                          • QLQ36610.1
                          		 5672228 - 5675017 (-) ATP-dependent helicase
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                            • H1D33_25610
                            • QLQ36611.1
                            		 5675143 - 5676177 (-) alpha-ketoacid dehydrogenase subunit beta
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                              • H1D33_25615
                              • QLQ40536.1
                              		 5676197 - 5677138 (-) thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha
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                                • H1D33_25620
                                • QLQ36612.1
                                		 5677240 - 5678721 (-) NDP-hexose 2,3-dehydratase family protein
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                                  • H1D33_25625
                                  • QLQ36613.1
                                  		 5678721 - 5680016 (-) activator-dependent family glycosyltransferase
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                                    • H1D33_25630
                                    		 5680076 - 5680304 (-) hypothetical protein
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                                      • H1D33_25635
                                      • QLQ36614.1
                                      		 5681234 - 5681809 (+) dTDP-4-dehydrorhamnose 3,5-epimerase family protein
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                                        • H1D33_25640
                                        • QLQ36615.1
                                        		 5681871 - 5682323 (-) nuclear transport factor 2 family protein
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                                          • H1D33_25645
                                          • QLQ36616.1
                                          		 5682529 - 5683536 (+) DMT family transporter
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                                            • H1D33_25650
                                            • QLQ36617.1
                                            		 5683577 - 5685028 (+) MFS transporter
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                                              • H1D33_25655
                                              • QLQ36618.1
                                              		 5685096 - 5686196 (-) alpha/beta fold hydrolase
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                                                • H1D33_25660
                                                • QLQ36619.1
                                                		 5686309 - 5687142 (-) ABC transporter permease
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                                                  • H1D33_25665
                                                  • QLQ36620.1
                                                  		 5687139 - 5688215 (-) ATP-binding cassette domain-containing protein
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                                                    • H1D33_25670
                                                    • QLQ36621.1
                                                    		 5688384 - 5689172 (-) TetR/AcrR family transcriptional regulator
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                                                      • H1D33_25675
                                                      • QLQ36622.1
                                                      		 5689244 - 5690140 (-) NmrA/HSCARG family protein
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                                                        • H1D33_25680
                                                        • QLQ36623.1
                                                        		 5690164 - 5691006 (-) NAD(P)H-binding protein
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                                                          • H1D33_25685
                                                          • QLQ36624.1
                                                          		 5691074 - 5691508 (-) ester cyclase
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                                                            • H1D33_25690
                                                            • QLQ36625.1
                                                            		 5691542 - 5691799 (-) acyl carrier protein
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                                                              • H1D33_25695
                                                              • QLQ36626.1
                                                              		 5691833 - 5693041 (-) ketosynthase chain-length factor
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                                                                • H1D33_25700
                                                                • QLQ36627.1
                                                                		 5693038 - 5694306 (-) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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                                                                  • H1D33_25705
                                                                  • QLQ36628.1
                                                                  		 5694303 - 5694656 (-) antibiotic biosynthesis monooxygenase
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                                                                    • H1D33_25710
                                                                    • QLQ36629.1
                                                                    		 5694851 - 5695636 (+) SDR family NAD(P)-dependent oxidoreductase
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                                                                      • H1D33_25715
                                                                      • QLQ36630.1
                                                                      		 5695665 - 5696624 (+) SRPBCC family protein
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                                                                        • H1D33_25720
                                                                        • QLQ40537.1
                                                                        		 5696696 - 5697427 (-) SDR family oxidoreductase
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                                                                          • H1D33_25725
                                                                          • QLQ36631.1
                                                                          • rfbB
                                                                          		 5697520 - 5698518 (-) dTDP-glucose 4,6-dehydratase
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                                                                            • H1D33_25730
                                                                            • QLQ40538.1
                                                                            • rfbA
                                                                            		 5698695 - 5699573 (+) glucose-1-phosphate thymidylyltransferase RfbA
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                                                                              • H1D33_25735
                                                                              • QLQ40539.1
                                                                              		 5700281 - 5701162 (+) AfsR/SARP family transcriptional regulator
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                                                                                • H1D33_25740
                                                                                • QLQ36632.1
                                                                                		 5701246 - 5701944 (-) indole-3-glycerol-phosphate synthase
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                                                                                  • H1D33_25745
                                                                                  • QLQ40540.1
                                                                                  		 5701977 - 5702633 (-) N-(5'-phosphoribosyl)anthranilate isomerase
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                                                                                    • H1D33_25750
                                                                                    • QLQ36633.1
                                                                                    		 5702643 - 5703782 (-) acyl-CoA dehydrogenase family protein
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                                                                                      • H1D33_25755
                                                                                      • QLQ36634.1
                                                                                      		 5703839 - 5704213 (-) ectoine synthase
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                                                                                        • H1D33_25760
                                                                                        • QLQ36635.1
                                                                                        • trpA
                                                                                        		 5704210 - 5705031 (-) tryptophan synthase subunit alpha
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                                                                                          • H1D33_25765
                                                                                          • QLQ36636.1
                                                                                          		 5705024 - 5706064 (-) hypothetical protein
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                                                                                            • H1D33_25770
                                                                                            • QLQ36637.1
                                                                                            		 5706067 - 5706330 (-) acyl carrier protein
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                                                                                              • H1D33_25775
                                                                                              • QLQ36638.1
                                                                                              		 5706332 - 5707813 (-) AMP-binding protein
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                                                                                                • H1D33_25780
                                                                                                • QLQ36639.1
                                                                                                		 5707843 - 5708619 (-) cyclase family protein
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                                                                                                  Biosynthesis information

                                                                                                  No biosynthesis information available for this record.

                                                                                                  Annotation changelog

                                                                                                  Entry version: 2

                                                                                                  Date
                                                                                                  Changes
                                                                                                  Submitters
                                                                                                  Reviewers
                                                                                                  2022-10-07
                                                                                                  Update chemical activity to schema version 2.11
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                  Entry version: 1

                                                                                                  Date
                                                                                                  Changes
                                                                                                  Submitters
                                                                                                  Reviewers
                                                                                                  2022-09-15
                                                                                                  Submitted
                                                                                                  • (ID: 4GMNAHXMUXC5VUH4UYMKD6EG)
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                  2022-09-15
                                                                                                  Added version to NCBI accession
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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