BGC0002101: heronamide C biosynthetic gene cluster from Streptomyces sp. CMB-0406 CBM-0406
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Location: 1 - 84,281 nt. (total: 84,281 nt).
This entry is originally from NCBI GenBank LT548273.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002101
Short description heronamide C biosynthetic gene cluster from Streptomyces sp. CMB-0406 CBM-0406
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
LT548273.1
via
Compounds
  • heronamide C
  • heronamide A
  • heronamide B
Species Streptomyces sp. CMB-0406 CBM-0406 [taxonomy]
References
Chemical products information
heronamide C Evidence: NMR
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C29H39N1O3
Chemical database entries
NPAtlas
heronamide A Evidence:
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Chemical database entries
NPAtlas
heronamide B Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SAI82894.1
  • hrnH
 <1920 - 4772 (+) HrnH; LuxR-type transcriptional regulator; Pfam00196
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    • SAI82895.1
    • hrnA1
    		 5170 - 24174 (+) HrnA1; Starter unit polyketide synthase type I; modules loading, 1-3
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      • SAI82896.1
      • hrnA2
      		 24212 - 27343 (+) HrnA2; Starter unit polyketide synthase type I; module 4 (partial)
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        • SAI82897.1
        • hrnI
        		 27509 - 28600 (-) HrnI; Glycine oxidase/FAD-dependent oxidoreductase; Pfam01266
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          • SAI82898.1
          • hrnC
          		 28597 - 30684 (-) HrnC; Starter unit polyketide synthase type I; module 4 (partial)
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            • SAI82899.1
            • hrnU
            		 30716 - 31279 (-) HrnU; putative NRPS accessory protein; Pfam10862
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              • SAI82900.1
              • hrnB
              		 31276 - 41856 (-) HrnB; Macrolactam polyketide synthase type I; modules loading, 1-2
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                • SAI82901.1
                • hrnJ
                		 41913 - 43511 (-) HrnJ; Putative AMP-dependent acyl-CoA synthetase/ligase; AMP-binding enzyme; Pfam00501
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                  • SAI82902.1
                  • hrnK
                  		 43738 - 44679 (+) HrnK; Acyltransferase
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                    • SAI82903.1
                    • hrnS
                    		 44696 - 44932 (-) HrnS; Peptidyl carrier protein; phosphopantetheine attachment site; Pfam00550
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                      • SAI82904.1
                      • hrnL
                      		 45050 - 46564 (+) HrnL; NRPS adenylation domain; AMP-binding enzyme; Long-chain fatty acid CoA ligase; Pfam00501
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                        • SAI82905.1
                        • hrnM
                        		 46547 - 47146 (-) HrnM; TetR-type transcriptional regulator; Pfam00440
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                          • SAI82906.1
                          • hrnN
                          		 47247 - 48818 (+) HrnN; Major facilitator; MFS_1 family; Pfam07690
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                            • SAI82907.1
                            • hrnO
                            		 48938 - >50173 (-) HrnO; P450 monooxygenase; Cytochrome P450; Pfam00067
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                              • SAI82908.1
                              • hrnD
                              		 50222 - 60328 (-) HrnD; Macrolactam polyketidesynthase type I; modules 3-4
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                                • SAI82909.1
                                • hrnP
                                		 60336 - 61271 (-) HrnP; Putative L-amino acid amidase/ proline iminopeptidase; alpha/beta hydrolase fold; Pfam00561
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                                  • SAI82910.1
                                  • hrnG
                                  		 61368 - 67373 (-) HrnG; Macrolactam polyketide synthase type I; module 8
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                                    • SAI82911.1
                                    • hrnF
                                    		 67381 - 77529 (-) HrnF; Macrolactam polyketide synthase type I; modules 6-7
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                                      • SAI82912.1
                                      • hrnE
                                      		 77573 - >82489 (-) HrnE; Macrolactam polyketide synthase type I; module 5
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                                        • SAI82913.1
                                        • hrnT
                                        		 82826 - 83092 (-) HrnT; SimX-like protein; Acyl-CoA carboxylase epsilon subunit; Pfam13822
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                                          • SAI82914.1
                                          • hrnQ
                                          		 83416 - 84186 (+) HrnQ; Thioesterase type II; Pfam00975
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                                            Biosynthesis information

                                            Biosynthetic modules

                                            Name
                                            1
                                            Type
                                            pks-modular
                                            Genes
                                            hrnA1
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                            Name
                                            2
                                            Type
                                            pks-modular
                                            Genes
                                            hrnA1
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                            Name
                                            3
                                            Type
                                            pks-modular
                                            Genes
                                            hrnA1
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                            Name
                                            4
                                            Type
                                            pks-modular
                                            Genes
                                            hrnA1
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                            Name
                                            5
                                            Type
                                            pks-modular
                                            Genes
                                            hrnA2
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            acyltransferase, ketosynthase, acyltransferase, dehydratase
                                            Name
                                            6
                                            Type
                                            pks-modular
                                            Genes
                                            hrnB
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP), carrier (ACP)
                                            Name
                                            7
                                            Type
                                            pks-modular
                                            Genes
                                            hrnB
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                            Name
                                            8
                                            Type
                                            pks-modular
                                            Genes
                                            hrnD
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                            Name
                                            9
                                            Type
                                            pks-modular
                                            Genes
                                            hrnD
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                            Name
                                            10
                                            Type
                                            pks-modular
                                            Genes
                                            hrnE
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                            Name
                                            11
                                            Type
                                            pks-modular
                                            Genes
                                            hrnF
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                            Name
                                            12
                                            Type
                                            pks-modular
                                            Genes
                                            hrnF
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                            Name
                                            13
                                            Type
                                            pks-modular
                                            Genes
                                            hrnG
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, thioesterase, carrier (ACP)
                                            Annotation changelog

                                            Entry version: 2

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-10-07
                                            Update chemical activity to schema version 2.11
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-10-07
                                            Changed chemical structures for compounds: heronamide C.
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-10-07
                                            Added compounds: heronamide A, heronamide B.
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-10-07
                                            Added NPAtlas links to compounds: heronamide A, heronamide B, heronamide C.
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 1

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-09-15
                                            Entry added
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Fix thioesterase IDs
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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