BGC0002107: fabrubactin A biosynthetic gene cluster from Agrobacterium fabrum str. C58
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Location: 715,559 - 769,035 nt. (total: 53,477 nt).
This entry is originally from NCBI GenBank AE007870.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002107
Short description fabrubactin A biosynthetic gene cluster from Agrobacterium fabrum str. C58
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
AE007870.2
715559 - 769035
via Enzymatic assays
Compounds
  • fabrubactin A
  • fabrubactin B
Species Agrobacterium fabrum str. C58 [taxonomy]
References
Chemical products information
fabrubactin A Evidence:
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Chemical database entries
NPAtlas
fabrubactin B Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Atu3667
  • AAK89734.1
  • panD
 715559 - 716026 (+) aspartate 1-decarboxylase
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    • Atu3668
    • AAK89733.1
    		 716058 - 716579 (-) siderophore biosynthesis protein
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      • Atu3669
      • AAK89732.2
      		 716694 - 718055 (-) siderophore biosynthesis protein
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        • Atu3670
        • AAK89731.2
        		 718087 - 721473 (-) siderophore biosynthesis protein
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          • Atu3671
          • AAK89730.1
          		 721484 - 722551 (-) siderophore biosynthesis protein
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            • Atu3672
            • AAK89729.1
            		 722591 - 727153 (-) polyketide synthase, siderophore biosynthesis protein
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              • Atu3673
              • AAK89728.2
              		 727195 - 729447 (-) siderophore biosynthesis protein
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                • Atu3674
                • AAL44486.1
                		 729520 - 729723 (-) hypothetical protein
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                  • Atu3675
                  • AAK89727.1
                  		 729769 - 734331 (+) peptide synthetase, siderophore biosynthesis protein
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                    • Atu3676
                    • AAK89726.1
                    		 734328 - 735224 (+) putative siderophore biosynthesis protein
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                      • Atu3677
                      • AAK89725.1
                      		 735221 - 736696 (+) polyketide synthase, siderophore biosynthesis protein
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                        • Atu3678
                        • AAK89724.2
                        		 736711 - 736950 (+) putative siderophore biosynthesis protein
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                          • Atu3679
                          • AAK89723.1
                          		 736961 - 737479 (+) putative siderophore biosynthesis protein
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                            • Atu3680
                            • AAK89722.2
                            		 737476 - 738039 (+) putative siderophore biosynthesis protein
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                              • Atu3681
                              • AAK89721.2
                              		 738077 - 742510 (+) polyketide synthetase, siderophore biosynthesis protein
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                                • Atu3682
                                • AAK89720.1
                                		 742507 - 749706 (+) non-ribosomal peptide synthetase, siderophore biosynthesis protein
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                                  • Atu3683
                                  • AAK89719.2
                                  		 749718 - 757409 (+) peptide synthetase, siderophore biosynthesis protein
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                                    • Atu3684
                                    • AAK89718.1
                                    		 757414 - 759081 (+) siderophore biosynthesis protein
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                                      • Atu3685
                                      • AAK89717.2
                                      		 759096 - 759842 (+) Thioesterase, putative siderophore biosynthesis protein
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                                        • Atu3686
                                        • AAK89716.1
                                        		 759870 - 760763 (+) putative siderophore biosynthesis protein
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                                          • Atu3687
                                          • AAK89715.2
                                          		 760897 - 763335 (+) TonB-dependent receptor
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                                            • Atu3688
                                            • AAK89714.2
                                            • fecB
                                            		 763389 - 764309 (+) ABC transporter, membrane spanning protein (iron(III) dicitrate)
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                                              • Atu3689
                                              • AAK89713.1
                                              • fecC
                                              		 764306 - 765355 (+) ABC transporter, membrane spanning protein (iron(III) dicitrate)
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                                                • Atu3690
                                                • AAK89712.2
                                                • fecD
                                                		 765352 - 766326 (+) ABC transporter, membrane spanning protein (iron (III) dicitrate)
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                                                  • Atu3691
                                                  • AAK89711.1
                                                  • fecE
                                                  		 766319 - 767122 (+) ABC transporter, nucleotide binding/ATPase protein (iron (III) dicitrate)
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                                                    • Atu3692
                                                    • AAK89710.2
                                                    		 767474 - 768016 (+) sigma factor
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                                                      • Atu3693
                                                      • AAK89709.1
                                                      • fecR
                                                      		 768064 - 769035 (+) two component sensor kinase
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                                                        Biosynthesis information

                                                        Biosynthetic modules

                                                        Name
                                                        Unk01
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        Atu3670
                                                        Substrates
                                                        beta-alanine (evidence: Structure-based inference, ATP-PPi exchange assay)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk02
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        Atu3682
                                                        Substrates
                                                        alanine (evidence: Structure-based inference, ATP-PPi exchange assay)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk03
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        Atu3682
                                                        Substrates
                                                        cysteine (evidence: Structure-based inference, ATP-PPi exchange assay)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk04
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        Atu3683
                                                        Substrates
                                                        glycine (evidence: Structure-based inference, ATP-PPi exchange assay)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk05
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        Atu3683
                                                        Substrates
                                                        alanine (evidence: Structure-based inference, ATP-PPi exchange assay)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk06
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        Atu3675
                                                        Substrates
                                                        3-hydroxytyrosine (evidence: Structure-based inference, ATP-PPi exchange assay)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Annotation changelog

                                                        Entry version: next

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2024-08-18
                                                        MIBiG v4 annotathon
                                                        • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 2

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-10-07
                                                        Added chemical structures for compounds: fabrubactin A, fabrubactin B.
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-10-07
                                                        Added NPAtlas links to compounds: fabrubactin A, fabrubactin B.
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 1

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-09-15
                                                        Entry added
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-09-15
                                                        Added NRP substrate specificities
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        Detailed domain annotation
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