BGC0002117: potashchelin A biosynthetic gene cluster from Halomonas sp. MG34
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Location: 498,345 - 580,165 nt. (total: 81,821 nt).
This entry is originally from NCBI GenBank WJPH01000003.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002117
Short description potashchelin A biosynthetic gene cluster from Halomonas sp. MG34
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
WJPH01000003.1
500633 - 569397
via
Compounds
  • potashchelin A
  • potashchelin B
  • potashchelin C
  • potashchelin D
Species Halomonas sp. MG34 [taxonomy]
References
Chemical products information
potashchelin A Evidence:
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Chemical database entries
NPAtlas
potashchelin B Evidence:
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Chemical database entries
NPAtlas
potashchelin C Evidence:
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Chemical database entries
NPAtlas
potashchelin D Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • FRY77_09780
  • NAO96300.1
 500633 - 501721 (+) DUF1513 domain-containing protein
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    • FRY77_09785
    • NAO96301.1
    		 501918 - 503570 (+) multidrug ABC transporter permease/ATP-binding protein
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      • FRY77_09790
      • NAO96302.1
      • fhuF
      		 503594 - 504382 (-) siderophore-iron reductase FhuF
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        • FRY77_09795
        • NAO96303.1
        		 504531 - 505298 (-) ATP-binding cassette domain-containing protein
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          • FRY77_09800
          • NAO96304.1
          		 505466 - 506263 (-) inositol monophosphatase
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            • FRY77_09805
            • NAO96305.1
            		 506374 - 507945 (-) AAA family ATPase
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              • FRY77_09810
              • NAO96306.1
              		 508014 - 509579 (-) AAA family ATPase
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                • FRY77_09815
                • NAO96307.1
                		 509880 - 512054 (+) TonB-dependent siderophore receptor
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                  • FRY77_09820
                  • NAO96308.1
                  		 512095 - 513135 (-) ABC transporter substrate-binding protein
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                    • FRY77_09825
                    • NAO96309.1
                    		 513081 - 515261 (-) TonB-dependent siderophore receptor
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                      • FRY77_09830
                      • NAO96310.1
                      		 515456 - 516061 (+) RNA polymerase factor sigma-70
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                        • FRY77_09835
                        • NAO96311.1
                        		 516185 - 516391 (+) DUF4880 domain-containing protein
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                          • FRY77_09840
                          • NAO96312.1
                          		 516647 - 516892 (+) MbtH family NRPS accessory protein
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                            • FRY77_09845
                            • NAO96313.1
                            		 516882 - 517622 (+) alpha/beta fold hydrolase
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                              • FRY77_09850
                              • NAO96314.1
                              		 517600 - 518412 (+) 4'-phosphopantetheinyl transferase superfamily protein
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                                • FRY77_09855
                                • NAO96315.1
                                		 518345 - 519346 (+) TauD/TfdA family dioxygenase
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                                  • FRY77_09860
                                  • NAO96316.1
                                  		 519392 - 523993 (+) AMP-binding protein
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                                    • FRY77_09865
                                    • NAO96317.1
                                    		 524019 - 527204 (+) amino acid adenylation domain-containing protein
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                                      • FRY77_09870
                                      • NAO96318.1
                                      		 527263 - 533772 (+) amino acid adenylation domain-containing protein
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                                        • FRY77_09875
                                        • NAO96319.1
                                        		 533769 - 540341 (+) amino acid adenylation domain-containing protein
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                                          • FRY77_09880
                                          • NAO96320.1
                                          		 540345 - 554069 (+) amino acid adenylation domain-containing protein
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                                            • FRY77_09885
                                            		 554137 - 554302 (-) IS630 family transposase
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                                              • FRY77_09890
                                              • NAO96321.1
                                              		 554377 - 555306 (-) ABC transporter substrate-binding protein
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                                                • FRY77_09895
                                                • NAO96322.1
                                                		 555476 - 557692 (-) TonB-dependent siderophore receptor
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                                                  • FRY77_09900
                                                  • NAO96323.1
                                                  		 557851 - 558804 (-) alpha/beta hydrolase fold domain-containing protein
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                                                    • FRY77_09905
                                                    • NAO96324.1
                                                    		 558870 - 560165 (-) SidA/IucD/PvdA family monooxygenase
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                                                      • FRY77_09910
                                                      • NAO96325.1
                                                      		 560189 - 561352 (-) GNAT family N-acetyltransferase
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                                                        • FRY77_09915
                                                        • NAO96326.1
                                                        		 561507 - 563153 (+) cyclic peptide export ABC transporter
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                                                          • FRY77_09920
                                                          • NAO96327.1
                                                          		 563139 - 563762 (-) cytochrome b
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                                                            • FRY77_09925
                                                            • NAO96328.1
                                                            		 563755 - 564699 (-) siderophore-interacting protein
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                                                              • FRY77_09930
                                                              • NAO96329.1
                                                              • fhuB
                                                              		 564889 - 566889 (+) Fe(3+)-hydroxamate ABC transporter permease FhuB
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                                                                • FRY77_09935
                                                                • NAO96330.1
                                                                • fhuF
                                                                		 566886 - 567674 (+) siderophore-iron reductase FhuF
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                                                                  • FRY77_09940
                                                                  • NAO96331.1
                                                                  		 567736 - 569397 (+) multidrug ABC transporter permease/ATP-binding protein
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                                                                    Biosynthesis information

                                                                    Biosynthetic modules

                                                                    Name
                                                                    Unk01
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    FRY77_09865
                                                                    Substrates
                                                                    aspartic acid (evidence: Structure-based inference, Homology)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk02
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    FRY77_09870
                                                                    Substrates
                                                                    serine (evidence: Structure-based inference [2])
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk03
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    FRY77_09870
                                                                    Substrates
                                                                    glycine (evidence: Structure-based inference [2])
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk04
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    FRY77_09875
                                                                    Substrates
                                                                    serine (evidence: Structure-based inference [2])
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk05
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    FRY77_09875
                                                                    Substrates
                                                                    serine (evidence: Structure-based inference, Homology)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk06
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    FRY77_09880
                                                                    Substrates
                                                                    aspartic acid (evidence: Structure-based inference [2])
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk07
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    FRY77_09880
                                                                    Substrates
                                                                    threonine (evidence: Structure-based inference [2])
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk08
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    FRY77_09880
                                                                    Substrates
                                                                    serine (evidence: Structure-based inference [2])
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk09
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    FRY77_09880
                                                                    Substrates
                                                                    N5-hydroxyornithine (evidence: Structure-based inference [2])
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Annotation changelog

                                                                    Entry version: 2

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2022-10-07
                                                                    Added chemical structures for compounds: potashchelin A, potashchelin B, potashchelin D, potashchelin C.
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    2022-10-07
                                                                    Added NPAtlas links to compounds: potashchelin A, potashchelin B, potashchelin D, potashchelin C.
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 1

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2022-09-15
                                                                    Entry added
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    2022-09-15
                                                                    Added NRP substrate specificities
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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