BGC0002130: cacaoidin biosynthetic gene cluster from Streptomyces cacaoi CA-170360
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Location: 1 - 29,760 nt. (total: 29,760 nt).
This entry is originally from NCBI GenBank MT210103.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002130
Short description cacaoidin biosynthetic gene cluster from Streptomyces cacaoi CA-170360
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
MT210103.1
via Heterologous expression
Compounds
  • cacaoidin
Species Streptomyces cacaoi CA-170360 [taxonomy]
References
Chemical products information
cacaoidin Evidence: NMR, Mass spectrometry
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C107H162N24O32S2
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QKI29061.1
  • caoR1
 475 - 1200 (-) DNA response regulator
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    • QKI29062.1
    • caoR2
    		 1953 - 2531 (+) XRE family transcriptional regulator
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      • QKI29063.1
      • cao3
      		 2528 - 3763 (+) dTDP-4-dehydrorhamnose reductase
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        • QKI29064.1
        • cao4
        		 3887 - 4936 (+) methyltransferase
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          • QKI29065.1
          • cao5
          		 5029 - 6009 (-) dTDP-glucose 4,6-dehydratase
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            • QKI29066.1
            • cao6
            		 6006 - 7073 (-) glucose-1-phosphate thymidylyltransferase
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              • QKI29067.1
              • cao7
              		 7257 - 8291 (+) hypothetical protein
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                • QKI29068.1
                • cao8
                		 8304 - 9455 (+) glycosyltransferase family 2
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                  • QKI29069.1
                  • cao9
                  		 9555 - 10697 (+) phosphotransferase
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                    • QKI29070.1
                    • caoA
                    		 10775 - 10936 (+) cacaoidin precursor peptide
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                      • QKI29071.1
                      • cao11
                      		 11058 - 12809 (+) ABC transporter ATP-binding protein
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                        • QKI29072.1
                        • cao12
                        		 12995 - 13945 (+) LLM class flavin-dependent oxidoreductase
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                          • QKI29073.1
                          • caoD
                          		 13942 - 14745 (+) cypemycin decarboxylase
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                            • QKI29074.1
                            • cao14
                            		 14730 - 15635 (+) hypothetical protein
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                              • QKI29075.1
                              • cao15
                              		 15632 - 18229 (+) Zn-dependent peptidase
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                                • QKI29076.1
                                • cao16
                                		 18226 - 19305 (+) glycosyltransferase family 2
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                                  • QKI29077.1
                                  • cao17
                                  		 19310 - 19456 (-) hypothetical protein
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                                    • QKI29078.1
                                    • cao18
                                    		 19660 - 20637 (+) ABC transporter ATP-binding protein
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                                      • QKI29079.1
                                      • cao19
                                      		 20634 - 21494 (+) ABC transporter permease
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                                        • QKI29080.1
                                        • caoR3
                                        		 21487 - 21819 (+) XRE family transcriptional regulator
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                                          • QKI29081.1
                                          • cao21
                                          		 21825 - 22373 (+) hypothetical protein
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                                            • QKI29082.1
                                            • caoR4
                                            		 22465 - 23082 (-) TetR family trancriptional regulator
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                                              • QKI29083.1
                                              • cao23
                                              		 23099 - 23593 (+) SRPBCC family protein
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                                                • QKI29084.1
                                                • cao24
                                                		 23816 - 25069 (+) glycosyltransferase family 4
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                                                  • QKI29085.1
                                                  • cao25
                                                  		 25066 - 26028 (+) hypothetical protein
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                                                    • QKI29086.1
                                                    • cao26
                                                    		 26191 - 26292 (-) hypothetical protein
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                                                      • QKI29087.1
                                                      • caoR5
                                                      		 26421 - 29471 (-) AfsR/SARP family transcriptional regulator
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                                                        Biosynthesis information
                                                        Annotation changelog

                                                        Entry version: 2

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-10-07
                                                        Update chemical activity to schema version 2.11
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-10-07
                                                        Added chemical structures for compounds: cacaoidin.
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-10-07
                                                        Added NPAtlas links to compounds: cacaoidin.
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 1

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-09-15
                                                        Entry added
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-09-15
                                                        Fix precursor gene ID
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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