BGC0002134: leupeptin A biosynthetic gene cluster from Xenorhabdus bovienii SS-2004
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Location: 578,227 - 604,000 nt. (total: 25,774 nt).
This entry is originally from NCBI GenBank FN667741.1.

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core biosynthetic genes
additional biosynthetic genes
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General
Compounds
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Biosynthesis
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KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002134
Short description leupeptin A biosynthetic gene cluster from Xenorhabdus bovienii SS-2004
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "This pathway is non-NRP, using separate AMP-dependent ligases to form amide bonds, with a reductase to form aldehyde."
Biosynthetic class(es)
  • other (other)
Loci
FN667741.1
588227 - 594000
via Heterologous expression
Compounds
  • leupeptin A
  • leupeptin B
  • leupeptin D
  • leupeptin C
Species Xenorhabdus bovienii SS-2004 [taxonomy]
References
Chemical products information
leupeptin A Evidence: Mass spectrometry, MS/MS
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C20H38N6O4
Chemical database entries
NPAtlas
leupeptin B Evidence: NMR, Mass spectrometry, Chemical derivatisation
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C23H35N3O5
leupeptin D Evidence: Mass spectrometry, Chemical derivatisation
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C19H35N3O4S1
leupeptin C Evidence: NMR, Mass spectrometry, Chemical derivatisation, Total synthesis
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C23H35N3O4
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • XBJ1_0572
  • CBJ79716.1
 588227 - 589132 (-) acetylation
  • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f970b2a1310>
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  • XBJ1_0573
  • CBJ79717.1
 589147 - 590418 (-) activate carboxylate with ATP and ligate second amino acid
  • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f970b2a1150>
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  • XBJ1_0574
  • CBJ79718.1
 590463 - 592868 (-) ligate third amino acid, reduce CoA thioester to aldehyde
  • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f970b2a0b10>
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  • XBJ1_0575
  • CBJ79719.1
 592870 - 594000 (-) activate carboxylate with CoA
  • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f970b29ffd0>
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Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

Entry version: 3

Date
Changes
Submitters
Reviewers
2023-12-04
Fix compound evidence
  • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 2

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-10-07
Changed chemical structures for compounds: leupeptin A.
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-10-07
Added NPAtlas links to compounds: leupeptin A.
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 1

Date
Changes
Submitters
Reviewers
2022-09-15
Submitted
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Added AMP-binding domain substrate specificities
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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