BGC0002137: mutaxanthene A biosynthetic gene cluster from Streptomyces sp. NRRL F-3213
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 164,492 - 222,940 nt. (total: 58,449 nt).
This entry is originally from NCBI GenBank NZ_JOIQ01000020.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002137
Short description mutaxanthene A biosynthetic gene cluster from Streptomyces sp. NRRL F-3213
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
NZ_JOIQ01000020.1
183729 - 216609
via Gene expression correlated with compound production
Compounds
  • mutaxanthene A
  • mutaxanthene B
  • mutaxanthene D
Species Streptomyces sp. NRRL F-3213 [taxonomy]
References
Chemical products information
mutaxanthene A Evidence: NMR [1]
Copy SMILES
C22H18O10
Chemical database entries
NPAtlas
PubCHEM
mutaxanthene B Evidence: NMR [1]
Copy SMILES
C23H20O10
Chemical database entries
PubCHEM
NPAtlas
mutaxanthene D Evidence: NMR [1]
Copy SMILES
C22H21N1O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • IF70_RS33670
  • WP_037817170.1
 183387 - 183770 (-) DUF1048 domain-containing protein
    copy AA seq
    copy Nt seq
    • IF70_RS33675
    • WP_037817171.1
    		 183760 - 184101 (-) PadR family transcriptional regulator
      copy AA seq
      copy Nt seq
      • IF70_RS33680
      • WP_037817174.1
      		 184177 - 184767 (-) hypothetical protein
        copy AA seq
        copy Nt seq
        • IF70_RS33685
        • WP_037817176.1
        		 184930 - 185202 (-) hypothetical protein
          copy AA seq
          copy Nt seq
          • IF70_RS33690
          • WP_037817178.1
          		 185531 - 186526 (-) acyltransferase domain-containing protein
            copy AA seq
            copy Nt seq
            • IF70_RS33695
            • WP_037817180.1
            		 186678 - 187712 (+) ketoacyl-ACP synthase III family protein
              copy AA seq
              copy Nt seq
              • IF70_RS33700
              • WP_037817183.1
              		 187770 - 188543 (-) cyclase family protein
                copy AA seq
                copy Nt seq
                • IF70_RS33705
                • WP_037817185.1
                		 188560 - 189309 (-) SDR family oxidoreductase
                  copy AA seq
                  copy Nt seq
                  • IF70_RS33710
                  • WP_051729283.1
                  		 189306 - 191159 (-) AMP-binding protein
                    copy AA seq
                    copy Nt seq
                    • IF70_RS33715
                    • WP_037817187.1
                    		 191152 - 192111 (-) aromatase/cyclase
                      copy AA seq
                      copy Nt seq
                      • IF70_RS33720
                      • WP_037817190.1
                      • fabG
                      		 192125 - 192910 (-) 3-oxoacyl-ACP reductase FabG
                        copy AA seq
                        copy Nt seq
                        • IF70_RS33725
                        • WP_037817193.1
                        		 192907 - 194142 (-) FAD-dependent monooxygenase
                          copy AA seq
                          copy Nt seq
                          • IF70_RS33730
                          • WP_037817196.1
                          		 194302 - 194763 (+) nuclear transport factor 2 family protein
                            copy AA seq
                            copy Nt seq
                            • IF70_RS33735
                            • WP_051729288.1
                            		 194766 - 195182 (+) nuclear transport factor 2 family protein
                              copy AA seq
                              copy Nt seq
                              • IF70_RS33740
                              • WP_037817202.1
                              		 195599 - 196357 (-) SDR family oxidoreductase
                                copy AA seq
                                copy Nt seq
                                • IF70_RS33745
                                • WP_051729290.1
                                		 196525 - 197547 (+) methyltransferase
                                  copy AA seq
                                  copy Nt seq
                                  • IF70_RS33750
                                  • WP_051729292.1
                                  		 197569 - 199098 (-) MFS transporter
                                    copy AA seq
                                    copy Nt seq
                                    • IF70_RS33755
                                    • WP_037817205.1
                                    		 199134 - 199391 (-) acyl carrier protein
                                      copy AA seq
                                      copy Nt seq
                                      • IF70_RS33760
                                      • WP_037817208.1
                                      		 199492 - 200697 (-) ketosynthase chain-length factor
                                        copy AA seq
                                        copy Nt seq
                                        • IF70_RS33765
                                        • WP_051729294.1
                                        		 200694 - 201986 (-) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
                                          copy AA seq
                                          copy Nt seq
                                          • IF70_RS33770
                                          • WP_078870628.1
                                          		 202151 - 204238 (-) AfsR/SARP family transcriptional regulator
                                            copy AA seq
                                            copy Nt seq
                                            • IF70_RS33775
                                            • WP_037817213.1
                                            		 204361 - 205116 (-) SDR family oxidoreductase
                                              copy AA seq
                                              copy Nt seq
                                              • IF70_RS33780
                                              • WP_078870630.1
                                              		 205151 - 206761 (-) FAD-dependent oxidoreductase
                                                copy AA seq
                                                copy Nt seq
                                                • IF70_RS33785
                                                • WP_037817215.1
                                                		 206698 - 207720 (-) methyltransferase
                                                  copy AA seq
                                                  copy Nt seq
                                                  • IF70_RS33790
                                                  • WP_051729299.1
                                                  		 207987 - 209501 (+) FAD-dependent monooxygenase
                                                    copy AA seq
                                                    copy Nt seq
                                                    • IF70_RS33795
                                                    • WP_078870629.1
                                                    		 209731 - 213414 (+) multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
                                                      copy AA seq
                                                      copy Nt seq
                                                      • IF70_RS33800
                                                      • WP_037817217.1
                                                      		 213512 - 213961 (-) nitroreductase family deazaflavin-dependent oxidoreductase
                                                        copy AA seq
                                                        copy Nt seq
                                                        • IF70_RS33805
                                                        • WP_078870631.1
                                                        		 214082 - 215350 (+) FAD-dependent oxidoreductase
                                                          copy AA seq
                                                          copy Nt seq
                                                          • IF70_RS33810
                                                          • WP_037817219.1
                                                          		 215410 - 216609 (+) MFS transporter
                                                            copy AA seq
                                                            copy Nt seq
                                                            • IF70_RS46140
                                                            • WP_199817943.1
                                                            		 216502 - 217029 (-) hypothetical protein
                                                              copy AA seq
                                                              copy Nt seq
                                                              Biosynthesis information

                                                              No biosynthesis information available for this record.

                                                              Annotation changelog

                                                              Entry version: 3

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2024-03-19
                                                              MIBiG v4 annotathon
                                                              • (ID: K5UBFDWZSYOHS4HI42NVQMJK)
                                                              • (ID: YO3TP6VWB5CBNPZKNYNQSKUW)
                                                              • (ID: NNE55MAGQGEH7CW7BAZQXJ3P)
                                                              • (ID: CVBS4CX3MGQ2Y6Q45INSO263)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                              Entry version: 2

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2022-10-07
                                                              Added NPAtlas links to compounds: mutaxanthene B, mutaxanthene C, mutaxanthene A.
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                              Entry version: 1

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2022-09-15
                                                              Submitted
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              Similar known clusters from MIBiG 4.0
                                                              Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                              Detailed help and explanations are available here.

                                                              Click on reference genes to show details of similarities to genes within the current region.
                                                              Double click on a reference drawing to reverse the display of the genes.

                                                              Click on an accession to open that entry in the MIBiG database.


                                                              Location:

                                                              Identifier
                                                              Identity
                                                              Coverage
                                                              Detailed domain annotation
                                                              Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                              A domain glossary is available here, and an explanation of the visualisation is available here.
                                                              Selected features only
                                                              Show module domains