BGC0002141: trioxacarcin A biosynthetic gene cluster from Streptomyces bottropensis DO-45
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Location: 1 - 79,353 nt. (total: 79,353 nt).
This entry is originally from NCBI GenBank KP410250.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002141
Short description trioxacarcin A biosynthetic gene cluster from Streptomyces bottropensis DO-45
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
KP410250.1
11766 - 74585
via Knock-out studies, Enzymatic assays, Heterologous expression, Gene expression correlated with compound production
Compounds
  • trioxacarcin A
Species Streptomyces bottropensis DO-45 [taxonomy]
References
Chemical products information
trioxacarcin A Evidence: NMR, Mass spectrometry, X-ray crystallography, Chemical derivatisation, Total synthesis
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Chemical database entries
PubCHEM
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List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AKT74254.1
 11766 - 12050 (+) TxnRg1
  • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f4dc07650d0>
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  • AKT74255.1
 12861 - 13853 (+) TxnB1
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    • AKT74256.1
    		 13976 - 14848 (-) TxnB2
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      • AKT74257.1
      		 15503 - 16486 (+) TxnB3
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        • AKT74258.1
        		 16520 - 17557 (+) TxnB4
        • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f4dc0765a50>
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        • AKT74259.1
        		 17875 - 19560 (-) TxnA4
        • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f4dc0765f10>
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        • AKT74260.1
        		 19718 - 19990 (-) TxnA3
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          • AKT74261.1
          		 20055 - 21275 (-) TxnA2
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            • AKT74262.1
            		 21272 - 22534 (-) TxnA1
            • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f4dc0766850>
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            • AKT74263.1
            		 22882 - 23673 (-) TxnRg2
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              • AKT74264.1
              		 24216 - 25400 (+) TxnRg3
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                • AKT74265.1
                		 25422 - 26033 (+) TxnRg4
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                  • AKT74266.1
                  		 26076 - 27815 (-) TxnP1
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                    • AKT74267.1
                    		 27953 - 28909 (-) TxnC1
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                      • AKT74268.1
                      		 28986 - 30020 (-) TxnA5
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                        • AKT74269.1
                        		 30049 - 31680 (-) TxnP2
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                          • AKT74270.1
                          		 31761 - 33014 (-) TxnP3
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                            • AKT74271.1
                            		 33234 - 34016 (+) TxnP4
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                              • AKT74272.1
                              		 34147 - 35649 (+) TxnRr1
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                                • AKT74273.1
                                		 35711 - 36748 (+) TxnO1
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                                  • AKT74274.1
                                  		 36809 - 37189 (-) TxnU1
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                                    • AKT74275.1
                                    		 37200 - 38405 (-) TxnO2
                                    • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f4dc0764c10>
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                                    • AKT74276.1
                                    		 38570 - 39670 (+) TxnU2
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                                      • AKT74277.1
                                      		 39710 - 40945 (-) TxnO3
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                                        • AKT74278.1
                                        		 40945 - 41268 (-) TxnO4
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                                          • AKT74279.1
                                          		 41505 - 42989 (+) TxnH1
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                                            • AKT74280.1
                                            		 43061 - 44290 (-) TxnO5
                                            • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f4dc071ce10>
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                                            • AKT74281.1
                                            		 44318 - 45439 (-) TxnH2
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                                              • AKT74282.1
                                              		 45557 - 46543 (-) TxnB5
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                                                • AKT74283.1
                                                		 46540 - 47181 (-) TxnB6
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                                                  • AKT74284.1
                                                  		 47187 - 48428 (-) TxnM1
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                                                    • AKT74285.1
                                                    		 48662 - 50128 (+) TxnB7
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                                                      • AKT74286.1
                                                      		 50125 - 51090 (+) TxnB8
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                                                        • AKT74287.1
                                                        		 51159 - 52661 (-) TxnRr2
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                                                          • AKT74288.1
                                                          		 52738 - 53757 (-) TxnRg5
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                                                            • AKT74289.1
                                                            		 53840 - 55060 (-) TxnO6
                                                            • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f4dc071f510>
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                                                            • AKT74290.1
                                                            		 55138 - 55665 (-) TxnO7
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                                                              • AKT74291.1
                                                              		 55823 - 56938 (-) TxnO8
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                                                                • AKT74292.1
                                                                		 56967 - 57431 (-) TxnO9
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                                                                  • AKT74293.1
                                                                  		 57618 - 58403 (+) TxnC2
                                                                  • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f4dc071c690>
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                                                                  • AKT74294.1
                                                                  		 58430 - 58966 (+) TxnO10
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                                                                    • AKT74295.1
                                                                    		 58987 - 59901 (+) TxnC3
                                                                    • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f4dc071cc50>
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                                                                    • AKT74296.1
                                                                    		 59929 - 61080 (-) TxnB9
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                                                                      • AKT74297.1
                                                                      		 61101 - 61547 (-) TxnO11
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                                                                        • AKT74298.1
                                                                        		 61741 - 62106 (+) TxnU3
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                                                                          • AKT74299.1
                                                                          		 62186 - 63460 (-) TxnB10
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                                                                            • AKT74300.1
                                                                            		 63554 - 64276 (-) TxnC4
                                                                            • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f4dc071de90>
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                                                                            • AKT74301.1
                                                                            		 64357 - 65379 (-) TxnM2
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                                                                              • AKT74302.1
                                                                              		 65500 - 66666 (-) TxnU4
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                                                                                • AKT74303.1
                                                                                		 66848 - 68041 (-) TxnB11
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                                                                                  • AKT74304.1
                                                                                  		 68070 - 69353 (-) TxnB12
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                                                                                    • AKT74305.1
                                                                                    		 69404 - 70423 (-) TxnM3
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                                                                                      • AKT74306.1
                                                                                      		 70474 - 71697 (-) TxnO12
                                                                                      • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f4dc071f050>
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                                                                                      • AKT74307.1
                                                                                      		 71731 - 72753 (-) TxnM4
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                                                                                        • AKT74308.1
                                                                                        		 73004 - 73552 (+) TxnU5
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                                                                                          • AKT74309.1
                                                                                          		 73725 - 74585 (-) TxnRg6
                                                                                          • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f4dc071f750>
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                                                                                          Biosynthesis information

                                                                                          No biosynthesis information available for this record.

                                                                                          Annotation changelog

                                                                                          Entry version: 2

                                                                                          Date
                                                                                          Changes
                                                                                          Submitters
                                                                                          Reviewers
                                                                                          2022-10-07
                                                                                          Update chemical activity to schema version 2.11
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                          Entry version: 1

                                                                                          Date
                                                                                          Changes
                                                                                          Submitters
                                                                                          Reviewers
                                                                                          2022-09-15
                                                                                          Submitted
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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