BGC0002142: gargantulide B biosynthetic gene cluster from Amycolatopsis sp. CA-230715
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Location: 2,017,289 - 2,235,663 nt. (total: 218,375 nt).
This entry is originally from NCBI GenBank CP059997.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002142
Short description gargantulide B biosynthetic gene cluster from Amycolatopsis sp. CA-230715
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
CP059997.1
2018398 - 2234914
via
Compounds
  • gargantulide B
  • gargantulide C
Species Amycolatopsis sp. CA-230715 [taxonomy]
References
Chemical products information
gargantulide B Evidence:
(no structure information available)
gargantulide C Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • HUW46_01925
  • QWF78529.1
 2018398 - 2019510 (-) hypothetical protein
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    • HUW46_01926
    • QWF78530.1
    • liaR_3
    		 2019772 - 2020440 (+) Transcriptional regulatory protein LiaR
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      • HUW46_01927
      • QWF78531.1
      		 2020803 - 2021024 (-) hypothetical protein
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        • HUW46_01928
        • QWF78532.1
        		 2021548 - 2022657 (-) IS4 family transposase ISMfl1
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          • HUW46_01929
          • QWF78533.1
          		 2022887 - 2025757 (+) hypothetical protein
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            • HUW46_01930
            • QWF78534.1
            • fadB2_1
            		 2025800 - 2026675 (-) 3-hydroxybutyryl-CoA dehydrogenase
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              • HUW46_01931
              • QWF78535.1
              • nphT7
              		 2026672 - 2027688 (-) Acetoacetyl CoA synthase NphT7
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                • HUW46_01932
                • QWF78536.1
                • ccr_2
                		 2027696 - 2029048 (-) Crotonyl-CoA reductase
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                  • HUW46_01933
                  • QWF78537.1
                  		 2029700 - 2031241 (+) hypothetical protein
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                    • HUW46_01934
                    • QWF78538.1
                    • desV_1
                    		 2031243 - 2032346 (-) dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
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                      • HUW46_01935
                      • QWF78539.1
                      		 2032343 - 2032813 (-) hypothetical protein
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                        • HUW46_01936
                        • QWF78540.1
                        		 2032932 - 2034290 (+) hypothetical protein
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                          • HUW46_01937
                          • QWF78541.1
                          • liaR_4
                          		 2034287 - 2034955 (+) Transcriptional regulatory protein LiaR
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                            • HUW46_01938
                            • QWF78542.1
                            • bioI_2
                            		 2034975 - 2036240 (-) Biotin biosynthesis cytochrome P450
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                              • HUW46_01939
                              • QWF78543.1
                              		 2036260 - 2037204 (-) hypothetical protein
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                                • HUW46_01940
                                • QWF78544.1
                                • fadA_2
                                		 2037289 - 2055021 (-) 3-ketoacyl-CoA thiolase
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                                  • HUW46_01941
                                  • QWF78545.1
                                  • fadA_3
                                  		 2055064 - 2072052 (-) 3-ketoacyl-CoA thiolase
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                                    • HUW46_01942
                                    • QWF78546.1
                                    • pikAII_1
                                    		 2072100 - 2082953 (-) Narbonolide/10-deoxymethynolide synthase PikA2, modules 3 and 4
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                                      • HUW46_01943
                                      • QWF78547.1
                                      • fadA_4
                                      		 2083013 - 2099056 (-) 3-ketoacyl-CoA thiolase
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                                        • HUW46_01944
                                        • QWF78548.1
                                        • fadA_5
                                        		 2099429 - 2113057 (-) 3-ketoacyl-CoA thiolase
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                                          • HUW46_01945
                                          • QWF78549.1
                                          • fadA_6
                                          		 2113096 - 2137323 (-) 3-ketoacyl-CoA thiolase
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                                            • HUW46_01946
                                            • QWF78550.1
                                            • fadA_7
                                            		 2137335 - 2155841 (-) 3-ketoacyl-CoA thiolase
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                                              • HUW46_01947
                                              • QWF78551.1
                                              		 2156249 - 2172484 (-) hypothetical protein
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                                                • HUW46_01948
                                                • QWF78552.1
                                                • fadA_8
                                                		 2172533 - 2201908 (-) 3-ketoacyl-CoA thiolase
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                                                  • HUW46_01949
                                                  • QWF78553.1
                                                  • fadA_9
                                                  		 2201957 - 2215663 (-) 3-ketoacyl-CoA thiolase
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                                                    • HUW46_01950
                                                    • QWF78554.1
                                                    • tylN_1
                                                    		 2215917 - 2217176 (-) O-mycaminosyltylonolide 6-deoxyallosyltransferase
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                                                      • HUW46_01951
                                                      • QWF78555.1
                                                      • tylN_2
                                                      		 2217267 - 2218532 (-) O-mycaminosyltylonolide 6-deoxyallosyltransferase
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                                                        • HUW46_01952
                                                        • QWF78556.1
                                                        		 2218562 - 2219935 (-) hypothetical protein
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                                                          • HUW46_01953
                                                          • QWF78557.1
                                                          		 2220042 - 2220296 (-) hypothetical protein
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                                                            • HUW46_01954
                                                            • QWF78558.1
                                                            • tylCV_1
                                                            		 2220752 - 2221942 (+) Demethyllactenocin mycarosyltransferase
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                                                              • HUW46_01955
                                                              • QWF78559.1
                                                              • bmrA
                                                              		 2222001 - 2223848 (-) Multidrug resistance ABC transporter ATP-binding/permease protein BmrA
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                                                                • HUW46_01956
                                                                • QWF78560.1
                                                                		 2223937 - 2224623 (+) hypothetical protein
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                                                                  • HUW46_01957
                                                                  • QWF78561.1
                                                                  		 2224986 - 2226560 (-) hypothetical protein
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                                                                    • HUW46_01958
                                                                    • QWF78562.1
                                                                    		 2226557 - 2227099 (-) hypothetical protein
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                                                                      • HUW46_01959
                                                                      • QWF78563.1
                                                                      • lcfB_2
                                                                      		 2227333 - 2228736 (-) Long-chain-fatty-acid--CoA ligase
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                                                                        • HUW46_01960
                                                                        • QWF78564.1
                                                                        • yxlF_1
                                                                        		 2228929 - 2229651 (-) putative ABC transporter ATP-binding protein YxlF
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                                                                          • HUW46_01961
                                                                          • QWF78565.1
                                                                          		 2229778 - 2231022 (+) hypothetical protein
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                                                                            • HUW46_01962
                                                                            • QWF78566.1
                                                                            		 2232098 - 2234914 (+) hypothetical protein
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                                                                              Biosynthesis information

                                                                              No biosynthesis information available for this record.

                                                                              Annotation changelog

                                                                              Entry version: 2

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2024-08-18
                                                                              MIBiG v4 annotathon
                                                                              • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                              Entry version: 1

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2022-09-15
                                                                              Entry added
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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