BGC0002181: pleuromutilin biosynthetic gene cluster from Rhodocybe pseudopiperita
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Location: 1 - 19,320 nt. (total: 19,320 nt).
This entry is originally from NCBI GenBank LC314149.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
Tailoring
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002181
Short description pleuromutilin biosynthetic gene cluster from Rhodocybe pseudopiperita
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • terpene (Unknown)
Loci
LC314149.1
via
Compounds
  • pleuromutilin
Species Rhodocybe pseudopiperita [taxonomy]
References
Chemical products information
pleuromutilin Evidence:
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Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BCI98769.1
  • ple1
 1004 - 3127 (+) Hydroxylase
  • Hydroxylation
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  • BCI98770.1
  • ple2
 3413 - 4711 (-) Acetylase
  • Acetylation
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  • BCI98771.1
  • ple3
 5684 - 8722 (-) putative terpene synthase
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    • BCI98772.1
    • ple4
    		 9660 - 10944 (+) putative prenyltransferase
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      • BCI98773.1
      • ple5
      		 11357 - 13653 (-) Hydroxylase
      • Hydroxylation
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      • BCI98774.1
      • ple6
      		 14506 - 16665 (-) Hydroxylase
      • Hydroxylation
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      • BCI98775.1
      • ple7
      		 17308 - 18265 (+) putative short chain dehydrogenase
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        Biosynthesis information

        No biosynthesis information available for this record.

        Annotation changelog

        Entry version: 3

        Date
        Changes
        Submitters
        Reviewers
        2024-08-06
        MIBiG v4 annotathon
        • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 2

        Date
        Changes
        Submitters
        Reviewers
        2022-10-07
        Changed chemical structures for compounds: pleuromutilin.
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-10-07
        Added NPAtlas links to compounds: pleuromutilin.
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 1

        Date
        Changes
        Submitters
        Reviewers
        2022-09-15
        Entry added
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        Tailoring functions
        Tailoring enzymes detected in this region
        Oxidoreductases: dehydrogenase oxygenase
        ple1: cytochrome P450
        smcogs
        SMCOG1034: cytochrome P450
        ple5: cytochrome P450
        smcogs
        SMCOG1034: cytochrome P450
        ple6: cytochrome P450
        smcogs
        SMCOG1034: cytochrome P450
        ple7: short-chain dehydrogenase/reductase SDR
        smcogs
        SMCOG1001: short-chain dehydrogenase/reductase SDR
        Ligases: synthetase
        ple4: Polyprenyl synthetase
        smcogs
        SMCOG1182: Polyprenyl synthetase
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