BGC0002198: nanangelenin B biosynthetic gene cluster from Aspergillus terreus var. terreus
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Location: 1 - 114,922 nt. (total: 114,922 nt).
This entry is originally from NCBI GenBank MT376588.1.

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core biosynthetic genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002198
Short description nanangelenin B biosynthetic gene cluster from Aspergillus terreus var. terreus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MT376588.1
1 - 114922
via Heterologous expression, Knock-out studies
Compounds
  • nanangelenin B
  • terreazepine
Species Aspergillus terreus var. terreus [taxonomy]
References
Chemical products information
nanangelenin B Evidence:
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Chemical database entries
NPAtlas
terreazepine Evidence:
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List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • FAC38_01
 1 - 3638 (-)
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    • FAC38_02
    		 5720 - 6960 (+)
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      • FAC38_03
      		 7142 - 8050 (-)
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        • FAC38_04
        		 9320 - 10876 (+)
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          • FAC38_06
          		 13927 - 15202 (-)
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            • FAC38_07
            		 15809 - 17277 (+)
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              • FAC38_08
              		 17339 - 19341 (-)
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                • FAC38_09
                		 19696 - 20883 (-)
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                  • FAC38_10
                  		 21284 - 22219 (+)
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                    • FAC38_11
                    		 24419 - 25889 (+)
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                      • FAC38_12
                      		 26262 - 27728 (+)
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                        • FAC38_13
                        		 27975 - 30440 (-)
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                          • FAC38_14
                          		 31052 - 33061 (+)
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                            • FAC38_15
                            		 33297 - 35119 (-)
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                              • QMS79048.1
                              • FAC38_16
                              		 36202 - 37800 (-) putative transporter C1039.04
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                                • QMS79049.1
                                • FAC38_17
                                		 39842 - 41073 (-) alcohol dehydrogenase 4
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                                  • QMS79050.1
                                  • FAC38_18
                                  		 41574 - 43019 (-) mannan endo-1,6-alpha-mannosidase DCW1
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                                    • QMS79051.1
                                    • FAC38_19
                                    		 44958 - 46671 (+) acetamidase
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                                      • QMS79052.1
                                      • FAC38_20
                                      		 51280 - 52326 (+) alkylglycerol monooxygenase
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                                        • QMS79053.1
                                        • FAC38_21
                                        		 54060 - 55756 (+) bifunctional solanapyrone synthase
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                                          • QMS79054.1
                                          • FAC38_22
                                          		 55976 - 58509 (-) lysine/arginine permease
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                                            • QMS79055.1
                                            • FAC38_23
                                            		 59727 - 61214 (+) putative protein unc-13 C
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                                              • QMS79056.1
                                              • FAC38_24
                                              		 61509 - 64500 (-) G-type lectin S-receptor-likeserine/threonine-protein kinase RLK1
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                                                • QMS79057.1
                                                • FAC38_25
                                                		 67006 - 68806 (-) dimethyl-sulfide monooxygenase
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                                                  • QMS79058.1
                                                  • FAC38_26
                                                  		 69887 - 72284 (+) putative urea active transporter 1
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                                                    • QMS79059.1
                                                    • FAC38_27
                                                    		 72668 - 73426 (-) hypothetical protein
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                                                      • QMS79060.1
                                                      • FAC38_28
                                                      		 74483 - 75130 (+) hypothetical protein
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                                                        • QMS79061.1
                                                        • FAC38_29
                                                        		 75732 - 75995 (+) follistatin-related protein 4
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                                                          • QMS79062.1
                                                          • FAC38_30
                                                          		 78293 - 79862 (+) ENOG410PXBM ankyrin repeat protein
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                                                            • QMS79063.1
                                                            • FAC38_31
                                                            		 81612 - 83202 (-) zinc-type alcohol dehydrogenase-like protein C1198.01
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                                                              • QMS79064.1
                                                              • FAC38_32
                                                              		 85540 - 87248 (-) high-affinity glucose transporter HXT2
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                                                                • QMS79065.1
                                                                • FAC38_33
                                                                		 87746 - 89287 (+) beta-fructofuranosidase insoluble isoenzyme CWINV1
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                                                                  • QMS79066.1
                                                                  • FAC38_34
                                                                  		 89324 - 91171 (-) transcriptional activator protein DAL81
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                                                                    • QMS79067.1
                                                                    • FAC38_35
                                                                    		 92115 - 99708 (-) nonribosomal peptide synthetase 12
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                                                                      • QMS79068.1
                                                                      • FAC38_36
                                                                      		 101178 - 102627 (-) indoleamine 2,3-dioxygenase
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                                                                        • QMS79069.1
                                                                        • FAC38_37
                                                                        		 105716 - 106234 (+) thaumatin-like protein
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                                                                          • QMS79070.1
                                                                          • FAC38_38
                                                                          		 107029 - 108331 (-) anhydro-N-acetylmuramic acid kinase
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                                                                            • QMS79071.1
                                                                            • FAC38_39
                                                                            		 109166 - 110878 (+) fumitremorgin C synthase
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                                                                              • QMS79072.1
                                                                              • FAC38_40
                                                                              		 111630 - 113101 (+) ENOG410PGZ4 transporter
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                                                                                • QMS79073.1
                                                                                • FAC38_41
                                                                                		 113891 - 114880 (+) kinesin light chain
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                                                                                  Biosynthesis information

                                                                                  Biosynthetic modules

                                                                                  Name
                                                                                  Unk01
                                                                                  Type
                                                                                  nrps-type1
                                                                                  Genes
                                                                                  FAC38_35
                                                                                  Substrates
                                                                                  anthranilic acid (evidence: Structure-based inference [1])
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  adenylation
                                                                                  Name
                                                                                  Unk02
                                                                                  Type
                                                                                  nrps-type1
                                                                                  Genes
                                                                                  FAC38_35
                                                                                  Substrates
                                                                                  kynurenine (evidence: Structure-based inference [1])
                                                                                  Integrated Monomers
                                                                                  Domains
                                                                                  adenylation
                                                                                  Annotation changelog

                                                                                  Entry version: 2

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2022-10-07
                                                                                  Added chemical structures for compounds: nanangelenin B.
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  2022-10-07
                                                                                  Added NPAtlas links to compounds: nanangelenin B.
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 1

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2022-09-15
                                                                                  Entry added
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  2022-09-15
                                                                                  Added NRP substrate specificities
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  Detailed domain annotation
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