BGC0002224: zopfiellin biosynthetic gene cluster from Diffractella curvata
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Location: 1 - 38,870 nt. (total: 38,870 nt).
This entry is originally from NCBI GenBank MT724049.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002224
Short description zopfiellin biosynthetic gene cluster from Diffractella curvata
Status Quality: high
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
MT724049.1
via Knock-out studies [1]
Compounds
  • zopfiellin
  • deoxyscytalidin
  • 5-hydroxy-deoxyscytalidin
  • deoxyzopfiellin
  • 5-hydroxy-deoxyscytalidin
Species Diffractella curvata [taxonomy]
References
Chemical products information
zopfiellin Evidence: NMR [1], X-ray crystallography [1], Chemical derivatisation [1], Mass spectrometry [1]
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C21H26O7
deoxyscytalidin Evidence: X-ray crystallography [1], NMR [1], Mass spectrometry [1]
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C22H28O6
Chemical database entries
NPAtlas
PubCHEM
ChEBI
5-hydroxy-deoxyscytalidin Evidence: X-ray crystallography [1], NMR [1], Mass spectrometry [1]
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C22H28O7
Chemical database entries
NPAtlas
deoxyzopfiellin Evidence: NMR [1]
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C21H26O6
5-hydroxy-deoxyscytalidin Evidence: NMR [1]
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C22H28O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QTE75983.1
  • zopL9
 686 - 1934 (-) hydroxylase/desaturase, α-ketoglutarate (aKG)-dependent dioxygenase
  • Hydroxylation
  • Ring contraction
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  • QTE75984.1
  • zopL8
 3212 - 4009 (-) ZopL8
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    • QTE75985.1
    • zopL7
    		 5476 - 6888 (+) ZopL7
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      • QTE75986.1
      • zopL6
      		 7415 - 9022 (-) ZopL6
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        • QTE75987.1
        • zopL5
        		 9900 - 11440 (+) ZopL5
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          • QTE75988.1
          • zopL4
          		 12081 - 12937 (-) ZopL4
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            • QTE75989.1
            • zopL3
            		 13598 - 15103 (+) ZopL3
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              • QTE75990.1
              • zopL2
              		 15346 - 15906 (-) ZopL2
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                • QTE75991.1
                • zopL1
                		 16901 - 17569 (+) ZopL1
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                  • QTE75992.1
                  • zopPKS
                  		 18235 - 26211 (-) polyketide synthase
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                    • QTE75993.1
                    • zopR1
                    		 27481 - 28211 (-) ZopR1
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                      • QTE75994.1
                      • zopR2
                      		 29207 - 30019 (-) ZopR2
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                        • QTE75995.1
                        • zopR3
                        		 30541 - 32073 (+) ZopR3
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                          • QTE75996.1
                          • zopR4
                          		 35687 - 37748 (+) ZopR4
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                            Biosynthesis information

                            No biosynthesis information available for this record.

                            Annotation changelog

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2025-08-05
                            Fixed gene annotations and added MITE cross-links
                            • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                            • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2024-05-14
                            MIBiG v4 annotathon
                            • (ID: WPXPP7X73ILZYNMVMGM7RHIM)
                            • (ID: HDJ3EC3TGIV3UPD32FQLYIFP)
                            • (ID: VMOLOUVCS4IRTX6AW6KNNWOL)
                            • (ID: EKZKD775F36BLONCQ7EXF7ZS)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Entry added
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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