BGC0002291: efomycin K biosynthetic gene cluster from Streptomyces sp. M56
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Location: 2,039,904 - 2,119,811 nt. (total: 79,908 nt).
This entry is originally from NCBI GenBank CP025018.1.

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General
Compounds
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Biosynthesis
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KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002291
Short description efomycin K biosynthetic gene cluster from Streptomyces sp. M56
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
CP025018.1
2046004 - 2109226
via
Compounds
  • efomycin K
  • efomycin L
Species Streptomyces sp. M56 [taxonomy]
References
Chemical products information
efomycin K Evidence:
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Chemical database entries
NPAtlas
efomycin L Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CFP59_01540
  • AUA09450.1
  • fpg2
 2046004 - 2046870 (-) putative formamidopyrimidine-DNA glycosylase-like protein
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    • CFP59_01541
    • AUA09451.1
    		 2047097 - 2048431 (+) Catalase
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      • CFP59_01542
      • AUA09452.1
      • ccr_1
      		 2048458 - 2049798 (-) Crotonyl-CoA reductase
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        • CFP59_01543
        • AUA09453.1
        		 2049911 - 2051335 (-) NDP-hexose 2,3-dehydratase
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          • CFP59_01544
          • AUA09454.1
          • gpr_6
          		 2051329 - 2052315 (-) L-glyceraldehyde 3-phosphate reductase
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            • CFP59_01545
            • AUA09455.1
            • tal_1
            		 2052315 - 2053280 (-) dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD(P)(+))
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              • CFP59_01546
              • AUA09456.1
              • liaR_3
              		 2053373 - 2054104 (-) Transcriptional regulatory protein LiaR
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                • CFP59_01547
                • AUA09457.1
                • liaS_1
                		 2054101 - 2055363 (-) Sensor histidine kinase LiaS
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                  • CFP59_01548
                  • AUA09458.1
                  • yhhJ
                  		 2055365 - 2056102 (-) Inner membrane transport permease YhhJ
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                    • CFP59_01549
                    • AUA09459.1
                    • drrA_5
                    		 2056125 - 2057039 (-) Daunorubicin/doxorubicin resistance ATP-binding protein DrrA
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                      • CFP59_01550
                      • AUA09460.1
                      • novW
                      		 2057201 - 2057797 (-) dTDP-4-dehydrorhamnose 3-epimerase
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                        • CFP59_01551
                        • AUA09461.1
                        • eryCIII
                        		 2057794 - 2059047 (-) Desosaminyl transferase EryCIII precursor
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                          • CFP59_01552
                          • AUA09462.1
                          • lgrE_2
                          		 2059062 - 2059847 (-) Linear gramicidin dehydrogenase LgrE
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                            • CFP59_01553
                            • AUA09463.1
                            		 2059904 - 2066155 (-) Phenolphthiocerol synthesis polyketide synthase type I Pks15/1
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                              • CFP59_01554
                              • AUA09464.1
                              • eryA_20
                              		 2066194 - 2076384 (-) Erythronolide synthase, modules 3 and 4
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                                • CFP59_01555
                                • AUA09465.1
                                • eryA_21
                                		 2076409 - 2081358 (-) Erythronolide synthase, modules 5 and 6
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                                  • CFP59_01556
                                  • AUA09466.1
                                  • eryA_22
                                  		 2081420 - 2086456 (-) Erythronolide synthase, modules 1 and 2
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                                    • CFP59_01557
                                    • AUA09467.1
                                    • eryA_23
                                    		 2086456 - 2099811 (-) Erythronolide synthase, modules 1 and 2
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                                      • CFP59_01558
                                      • AUA09468.1
                                      • strE_1
                                      		 2099948 - 2100922 (-) dTDP-glucose 4,6-dehydratase
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                                        • CFP59_01559
                                        • AUA09469.1
                                        • rmlA2
                                        		 2100936 - 2101808 (-) Glucose-1-phosphate thymidylyltransferase 2
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                                          • CFP59_01560
                                          • AUA09470.1
                                          • nreC_4
                                          		 2101945 - 2104821 (-) Oxygen regulatory protein NreC
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                                            • CFP59_01561
                                            • AUA09471.1
                                            • fadB2_1
                                            		 2105382 - 2107100 (-) 3-hydroxybutyryl-CoA dehydrogenase
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                                              • CFP59_01562
                                              • AUA09472.1
                                              		 2107403 - 2108887 (+) hypothetical protein
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                                                • CFP59_01563
                                                • AUA09473.1
                                                		 2108906 - 2109226 (-) hypothetical protein
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                                                  Biosynthesis information

                                                  No biosynthesis information available for this record.

                                                  Annotation changelog

                                                  Entry version: 2

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-10-07
                                                  Changed chemical structures for compounds: efomycin L, efomycin K.
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-10-07
                                                  Added NPAtlas links to compounds: efomycin L, efomycin K.
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 1

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-09-15
                                                  Entry added
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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