BGC0002349: epemicin B biosynthetic gene cluster from Kutzneria sp. CA-103260
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Location: 11,225,585 - 11,357,507 nt. (total: 131,923 nt).
This entry is originally from NCBI GenBank CP073318.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002349
Short description epemicin B biosynthetic gene cluster from Kutzneria sp. CA-103260
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
CP073318.1
11226555 - 11355273
via Heterologous expression, Knock-out studies
Compounds
  • epemicin B
  • epemicin A
Species Kutzneria sp. CA-103260 [taxonomy]
References
Chemical products information
epemicin B Evidence: NMR [2]
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C70H122N2O27
Chemical database entries
NPAtlas
epemicin A Evidence: NMR [2]
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C76H132N2O32
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • JJ691_101180
  • QUQ72330.1
 11226555 - 11227787 (+) sensor histidine kinase
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    • JJ691_101190
    • QUQ72331.1
    		 11227760 - 11228449 (+) two-component system response regulator
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      • JJ691_101200
      • QUQ72332.1
      		 11228603 - 11229052 (+) hypothetical protein
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        • JJ691_101210
        • QUQ72333.1
        		 11229078 - 11229398 (+) hypothetical protein
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          • JJ691_101220
          • QUQ72334.1
          		 11229580 - 11232189 (+) MalT-family transcriptional regulator
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            • JJ691_101230
            • QUQ72335.1
            		 11232186 - 11234636 (+) LuxR-family transcriptional regulator
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              • JJ691_101240
              • QUQ72336.1
              • malT_20
              		 11234645 - 11237383 (+) LuxR-family transcriptional regulator
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                • JJ691_101250
                • QUQ72337.1
                		 11238249 - 11238929 (+) LuxR-family transcription regulator
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                  • JJ691_101260
                  • QUQ72338.1
                  • rfbB_3
                  		 11238922 - 11239908 (-) dTDP-glucose 4,6-dehydratase
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                    • JJ691_101270
                    • QUQ72339.1
                    • rfbC_4
                    		 11240123 - 11240701 (+) dTDP-4-dehydrorhamnose 3,5- epimerase family protein
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                      • JJ691_101280
                      • QUQ72340.1
                      • rfbA_3
                      		 11240842 - 11241714 (+) glucose-1-phosphate thymidylyltransferase
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                        • JJ691_101290
                        • QUQ72341.1
                        		 11241731 - 11242942 (+) GT1-family glycosyltransferase
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                          • JJ691_101300
                          • QUQ72342.1
                          		 11242939 - 11244174 (+) GT1-family glycosyltransferase
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                            • JJ691_101310
                            • QUQ72343.1
                            		 11244174 - 11245406 (+) cytochrome P450
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                              • JJ691_101320
                              • QUQ72344.1
                              • fadA_6
                              		 11245585 - 11255013 (+) type I polyketide synthase
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                                • JJ691_101330
                                • QUQ72345.1
                                • fadA_7
                                		 11255006 - 11277556 (+) type I polyketide synthase
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                                  • JJ691_101350
                                  • QUQ72346.1
                                  		 11277612 - 11279126 (+) dolichyl-phosphate-mannose- protein mannosyltransferase
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                                    • JJ691_101360
                                    • QUQ72347.1
                                    • fadA_8
                                    		 11279395 - 11301855 (+) type I polyketide synthase
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                                      • JJ691_101370
                                      • QUQ72348.1
                                      		 11301884 - 11311084 (+) type I polyketide synthase
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                                        • JJ691_101380
                                        • QUQ72349.1
                                        		 11311133 - 11317138 (+) type I polyketide synthase
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                                          • JJ691_101390
                                          • QUQ72350.1
                                          		 11317512 - 11318657 (-) hypothetical protein
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                                            • JJ691_101400
                                            • QUQ72351.1
                                            • paaH_6
                                            		 11319095 - 11320792 (-) 3-hydroxyacyl-CoA dehydrogenase
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                                              • JJ691_101410
                                              • QUQ72352.1
                                              • ccrA
                                              		 11320811 - 11322145 (-) crotonyl-CoA carboxylase/ reductase
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                                                • JJ691_101420
                                                • QUQ72353.1
                                                		 11322260 - 11334217 (-) type I polyketide synthase
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                                                  • JJ691_101430
                                                  • QUQ72354.1
                                                  		 11334311 - 11335078 (-) nucleoside-diphosphate-sugar epimerase
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                                                    • JJ691_101440
                                                    • QUQ72355.1
                                                    		 11335241 - 11335912 (-) putative DNA binding response regulator
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                                                      • JJ691_101450
                                                      • QUQ72356.1
                                                      		 11336145 - 11337356 (+) histidine kinase
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                                                        • JJ691_101460
                                                        • QUQ72357.1
                                                        		 11337510 - 11337833 (+) hypothetical protein
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                                                          • JJ691_101470
                                                          • QUQ72358.1
                                                          		 11338034 - 11339218 (+) class I SAM-dependent methyltransferase
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                                                            • JJ691_101480
                                                            • QUQ72359.1
                                                            		 11339330 - 11340211 (-) F420- dependent LLM class oxidoreductase
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                                                              • JJ691_101490
                                                              • QUQ72360.1
                                                              		 11340255 - 11341457 (-) GT1 family glycosyltransferase
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                                                                • JJ691_101500
                                                                • QUQ72361.1
                                                                		 11341637 - 11342230 (+) dTDP-4-dehydrorhamnose 3,5- epimerase family protein
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                                                                  • JJ691_101510
                                                                  • QUQ72362.1
                                                                  		 11342338 - 11343801 (+) NDP-hexose 2,3-dehydratase family protein
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                                                                    • JJ691_101520
                                                                    • QUQ72363.1
                                                                    		 11343875 - 11345122 (-) GT1 family glycosyltransferase
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                                                                      • JJ691_101530
                                                                      • QUQ72364.1
                                                                      		 11345193 - 11346302 (-) DegT/DnrJ/EryC1/StrS family aminotransferase
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                                                                        • JJ691_101540
                                                                        • QUQ72365.1
                                                                        		 11346299 - 11347507 (-) GT1 family glycosyltransferase
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                                                                          • JJ691_101550
                                                                          • QUQ72366.1
                                                                          		 11347776 - 11348570 (+) NAD-dependent epimerase/ dehydratase family protein
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                                                                            • JJ691_101560
                                                                            • QUQ72367.1
                                                                            		 11349077 - 11350903 (+) ABC transporter ATP-binding protein
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                                                                              • JJ691_101570
                                                                              • QUQ72368.1
                                                                              		 11350908 - 11352512 (+) family 20 glycosylhydrolase
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                                                                                • JJ691_101580
                                                                                • QUQ72369.1
                                                                                		 11352591 - 11353595 (-) beta-ketoacyl-ACP synthase III
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                                                                                  • JJ691_101590
                                                                                  • QUQ72370.1
                                                                                  		 11353993 - 11354568 (-) TetR family transcription regulator
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                                                                                    • JJ691_101600
                                                                                    • QUQ72371.1
                                                                                    		 11354911 - 11355273 (+) family 20 glycosylhydrolase
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                                                                                      Biosynthesis information

                                                                                      No biosynthesis information available for this record.

                                                                                      Annotation changelog

                                                                                      Entry version: 3

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2024-03-20
                                                                                      MIBiG v4 annotathon
                                                                                      • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                      Entry version: 2

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2022-10-07
                                                                                      Changed chemical structures for compounds: epemicin B, epemicin A.
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      2022-10-07
                                                                                      Added NPAtlas links to compounds: epemicin B, epemicin A.
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                      Entry version: 1

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2022-09-15
                                                                                      Entry added
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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