BGC0002358: cyclofaulknamycin biosynthetic gene cluster from Streptomyces albidoflavus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1,139,018 - 1,186,162 nt. (total: 47,145 nt).
This entry is originally from NCBI GenBank CP004370.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002358
Short description cyclofaulknamycin biosynthetic gene cluster from Streptomyces albidoflavus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
CP004370.1
1139018 - 1186162
via Knock-out studies
Compounds
  • cyclofaulknamycin
Species Streptomyces albidoflavus [taxonomy]
References
Chemical products information
cyclofaulknamycin Evidence:
Copy SMILES
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • XNR_0968
  • AGI87367.1
 1139018 - 1139779 (+) DeoR-family transcriptional regulator
    copy AA seq
    copy Nt seq
    • XNR_0969
    • AGI87368.1
    		 1139902 - 1141269 (+) Substrate binding protein
      copy AA seq
      copy Nt seq
      • XNR_0970
      • AGI87369.1
      		 1141266 - 1142234 (+) Integral membrane sugar transporter
        copy AA seq
        copy Nt seq
        • XNR_0971
        • AGI87370.1
        		 1142231 - 1143097 (+) Sugar ABC transporter permease
          copy AA seq
          copy Nt seq
          • XNR_0972
          • AGI87371.1
          		 1143094 - 1144089 (+) Zinc-binding dehydrogenase
            copy AA seq
            copy Nt seq
            • XNR_0973
            • AGI87372.1
            		 1144346 - 1145515 (+) Integral membrane protein
              copy AA seq
              copy Nt seq
              • XNR_0974
              • AGI87373.1
              		 1145512 - 1146243 (+) Methyltransferase FkbM
                copy AA seq
                copy Nt seq
                • XNR_0975
                • AGI87374.1
                		 1146289 - 1147443 (+) Glycosyl transferase
                  copy AA seq
                  copy Nt seq
                  • XNR_0976
                  • AGI87375.1
                  		 1147504 - 1148169 (-) Two-component system response regulator
                    copy AA seq
                    copy Nt seq
                    • XNR_0977
                    • AGI87376.1
                    		 1148157 - 1149434 (-) Two-component system sensorhistidine kinase
                      copy AA seq
                      copy Nt seq
                      • XNR_0978
                      • AGI87377.1
                      		 1149584 - 1150330 (+) ABC transporter ATP-binding protein
                        copy AA seq
                        copy Nt seq
                        • XNR_0979
                        • AGI87378.1
                        		 1150330 - 1152324 (+) ABC-type antimicrobial peptide transport system,permease component
                          copy AA seq
                          copy Nt seq
                          • XNR_0980
                          • AGI87379.1
                          		 1152610 - 1153281 (+) Two-component system response regulator
                            copy AA seq
                            copy Nt seq
                            • XNR_0981
                            • AGI87380.1
                            		 1153300 - 1154673 (+) Two-component system sensorhistidine kinase
                              copy AA seq
                              copy Nt seq
                              • XNR_0982
                              • AGI87381.1
                              		 1154805 - 1156145 (+) Alpha/beta hydrolase MppKBeta-lactamase
                                copy AA seq
                                copy Nt seq
                                • XNR_0983
                                • AGI87382.1
                                		 1156316 - 1166554 (+) Peptide synthase
                                  copy AA seq
                                  copy Nt seq
                                  • XNR_0984
                                  • AGI87383.1
                                  		 1166608 - 1166814 (+) MbtH-like protein
                                    copy AA seq
                                    copy Nt seq
                                    • XNR_0985
                                    • AGI87384.1
                                    		 1166967 - 1179422 (+) Peptide synthase
                                      copy AA seq
                                      copy Nt seq
                                      • XNR_0986
                                      • AGI87385.1
                                      		 1179447 - 1180427 (+) oxygenase (secreted protein)
                                        copy AA seq
                                        copy Nt seq
                                        • XNR_0987
                                        • AGI87386.1
                                        		 1180427 - 1181881 (+) Permeases of the major facilitator superfamily
                                          copy AA seq
                                          copy Nt seq
                                          • XNR_0988
                                          • AGI87387.1
                                          		 1181944 - 1183122 (+) cytochrome P450 hydroxylase
                                            copy AA seq
                                            copy Nt seq
                                            • XNR_0989
                                            • AGI87388.1
                                            		 1183176 - 1183988 (+) regulatory protein
                                              copy AA seq
                                              copy Nt seq
                                              • XNR_0990
                                              • AGI87389.1
                                              		 1184007 - 1184744 (+) putative thioesterase involved in non-ribosomalpeptide biosynthesis
                                                copy AA seq
                                                copy Nt seq
                                                • XNR_0991
                                                • AGI87390.1
                                                		 1184831 - 1186162 (+) Succinoglycan biosynthesis protein
                                                  copy AA seq
                                                  copy Nt seq
                                                  Biosynthesis information
                                                  Annotation changelog

                                                  Entry version: 2

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-10-07
                                                  Added chemical structures for compounds: cyclofaulknamycin.
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-10-07
                                                  Added NPAtlas links to compounds: cyclofaulknamycin.
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 1

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-09-15
                                                  Entry added
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  Detailed domain annotation
                                                  Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                  A domain glossary is available here, and an explanation of the visualisation is available here.
                                                  Selected features only
                                                  Show module domains
                                                  Similar known gene clusters from MIBiG 4.0
                                                  Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                  Click on reference genes to show details of similarities to genes within the current region.
                                                  Click on an accession to open that entry in the MiBIG database.