BGC0002370: zelkovamycin B biosynthetic gene cluster from Actinomadura graeca
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Location: 3,040,327 - 3,113,720 nt. (total: 73,394 nt).
This entry is originally from NCBI GenBank CP059572.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
Modifications
General information about the BGC
MIBiG accession BGC0002370
Short description zelkovamycin B biosynthetic gene cluster from Actinomadura graeca
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP059572.1
3040488 - 3100478
via Gene expression correlated with compound production
Compounds
  • zelkovamycin B
  • zelkovamycin C
  • zelkovamycin D
  • zelkovamycin E
Species Actinomadura graeca [taxonomy]
References
Chemical products information
zelkovamycin B Evidence:
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Chemical database entries
NPAtlas
zelkovamycin C Evidence:
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Chemical database entries
NPAtlas
zelkovamycin D Evidence:
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Chemical database entries
NPAtlas
zelkovamycin E Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGRA3207_002682
  • QXJ26480.1
 3040488 - 3041774 (-) homoserine dehydrogenase
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    • AGRA3207_002683
    • QXJ21792.1
    • lysA
    		 3041798 - 3043189 (-) diaminopimelate decarboxylase
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      • AGRA3207_002684
      • QXJ21793.1
      		 3043186 - 3043866 (-) anticodon-binding protein
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        • AGRA3207_002685
        • QXJ26481.1
        		 3043903 - 3044265 (-) response regulator
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          • AGRA3207_002687
          • QXJ21794.1
          		 3044926 - 3045738 (+) hypothetical protein
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            • AGRA3207_002688
            		 3045798 - 3046383 (-) transposase
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              • AGRA3207_002689
              • QXJ21795.1
              		 3046467 - 3049379 (-) hypothetical protein
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                • AGRA3207_002690
                • QXJ26482.1
                		 3049558 - 3049812 (+) hypothetical protein
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                  • AGRA3207_002691
                  • QXJ21796.1
                  		 3049949 - 3050665 (+) response regulator transcription factor
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                    • AGRA3207_002692
                    • QXJ21797.1
                    		 3050901 - 3051353 (-) hypothetical protein
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                      • AGRA3207_002693
                      • QXJ21798.1
                      		 3051693 - 3052628 (-) branched-chain amino acid ABC transporter permease
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                        • AGRA3207_002694
                        • QXJ21799.1
                        		 3052625 - 3053488 (-) branched-chain amino acid ABC transporter permease
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                          • AGRA3207_002695
                          • QXJ26483.1
                          		 3053485 - 3054153 (-) ABC transporter ATP-binding protein
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                            • AGRA3207_002696
                            • QXJ21800.1
                            		 3054159 - 3054926 (-) ABC transporter ATP-binding protein
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                              • AGRA3207_002697
                              • QXJ21801.1
                              		 3054923 - 3056113 (-) ABC transporter substrate-binding protein
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                                • AGRA3207_002698
                                • QXJ26484.1
                                		 3056292 - 3057071 (+) PaaX family transcriptional regulator
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                                  • AGRA3207_002699
                                  • QXJ21802.1
                                  		 3057366 - 3058724 (+) alpha/beta hydrolase
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                                    • AGRA3207_002700
                                    • QXJ26485.1
                                    		 3060327 - 3063215 (-) amino acid adenylation domain-containing protein
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                                      • AGRA3207_002701
                                      • QXJ26486.1
                                      		 3063254 - 3064078 (-) mycofactocin-coupled SDR family oxidoreductase
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                                        • AGRA3207_002702
                                        • QXJ21803.1
                                        		 3064106 - 3064804 (-) thioesterase
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                                          • AGRA3207_002703
                                          • QXJ21804.1
                                          		 3064824 - 3065567 (-) thioesterase
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                                            • AGRA3207_002704
                                            • QXJ21805.1
                                            		 3065605 - 3066756 (-) hypothetical protein
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                                              • AGRA3207_002705
                                              • QXJ21806.1
                                              		 3066811 - 3067815 (-) hydroxyneurosporene methyltransferase
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                                                • AGRA3207_002706
                                                • QXJ21807.1
                                                		 3067812 - 3074834 (-) amino acid adenylation domain-containing protein
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                                                  • AGRA3207_002707
                                                  • QXJ21808.1
                                                  		 3074834 - 3085534 (-) amino acid adenylation domain-containing protein
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                                                    • AGRA3207_002708
                                                    • QXJ21809.1
                                                    		 3085564 - 3093720 (-) amino acid adenylation domain-containing protein
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                                                      • AGRA3207_002709
                                                      • QXJ21810.1
                                                      		 3093867 - 3094709 (-) aminotransferase class IV
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                                                        • AGRA3207_002710
                                                        • QXJ21811.1
                                                        		 3094949 - 3096505 (+) amino acid adenylation domain-containing protein
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                                                          • AGRA3207_002711
                                                          • QXJ21812.1
                                                          		 3096627 - 3097463 (-) class I SAM-dependent methyltransferase
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                                                            • AGRA3207_002712
                                                            • QXJ21813.1
                                                            		 3098232 - 3100478 (-) MMPL family transporter
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                                                              • AGRA3207_002713
                                                              • QXJ21814.1
                                                              		 3100472 - 3101647 (-) acyl-CoA dehydrogenase family protein
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                                                                Biosynthesis information

                                                                Biosynthetic modules

                                                                Name
                                                                Unk01
                                                                Type
                                                                nrps-type1
                                                                Genes
                                                                AGRA3207_002700
                                                                Substrates
                                                                threonine (evidence: Structure-based inference, Homology)
                                                                Integrated Monomers
                                                                Domains
                                                                adenylation
                                                                Name
                                                                Unk02
                                                                Type
                                                                nrps-type1
                                                                Genes
                                                                AGRA3207_002706
                                                                Substrates
                                                                2S-methyl-3-oxobutyrine (evidence: Structure-based inference, Homology)
                                                                Integrated Monomers
                                                                Domains
                                                                adenylation
                                                                Name
                                                                Unk03
                                                                Type
                                                                nrps-type1
                                                                Genes
                                                                AGRA3207_002706
                                                                Substrates
                                                                glycine (evidence: Structure-based inference, Homology)
                                                                Integrated Monomers
                                                                Domains
                                                                adenylation
                                                                Name
                                                                Unk04
                                                                Type
                                                                nrps-type1
                                                                Genes
                                                                AGRA3207_002707
                                                                Substrates
                                                                alanine (evidence: Structure-based inference, Homology)
                                                                Integrated Monomers
                                                                Domains
                                                                adenylation
                                                                Name
                                                                Unk05
                                                                Type
                                                                nrps-type1
                                                                Genes
                                                                AGRA3207_002707
                                                                Substrates
                                                                cysteine (evidence: Structure-based inference, Homology)
                                                                Integrated Monomers
                                                                Domains
                                                                adenylation
                                                                Name
                                                                Unk06
                                                                Type
                                                                nrps-type1
                                                                Genes
                                                                AGRA3207_002707
                                                                Substrates
                                                                tryptophan (evidence: Structure-based inference, Homology)
                                                                Integrated Monomers
                                                                Domains
                                                                adenylation
                                                                Name
                                                                Unk07
                                                                Type
                                                                nrps-type1
                                                                Genes
                                                                AGRA3207_002708
                                                                Substrates
                                                                2-aminobutyric acid (evidence: Structure-based inference, Homology)
                                                                Integrated Monomers
                                                                Domains
                                                                adenylation
                                                                Name
                                                                Unk08
                                                                Type
                                                                nrps-type1
                                                                Genes
                                                                AGRA3207_002708
                                                                Substrates
                                                                glycine (evidence: Structure-based inference, Homology)
                                                                Integrated Monomers
                                                                Domains
                                                                adenylation
                                                                Annotation changelog

                                                                Entry version: 1

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2022-09-15
                                                                Entry added
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                2022-09-15
                                                                Added NRP substrate specificities
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                                                                Identifier
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                                                                Detailed domain annotation
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                                                                Modifications to original record
                                                                • AGRA3207_000001 crossed the origin and was split into two features