BGC0002373: bonnevillamide D biosynthetic gene cluster from Streptomyces sp.
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Location: 1 - 56,944 nt. (total: 56,944 nt).
This entry is originally from NCBI GenBank MW590581.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002373
Short description bonnevillamide D biosynthetic gene cluster from Streptomyces sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MW590581.1
1 - 56944
via
Compounds
  • bonnevillamide D
  • bonnevillamide E
Species Streptomyces sp. [taxonomy]
References
Chemical products information
bonnevillamide D Evidence: NMR [1]
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C44H64Cl2N6O14
Chemical database entries
NPAtlas
bonnevillamide E Evidence: NMR [1]
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C44H62Cl2N6O13
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QVQ62871.1
 1 - 1170 (+) pyruvate carboxyltransferase
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    • QVQ62870.1
    		 1198 - 2607 (+) 3-isopropylmalate dehydratase large subunit
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      • QVQ62869.1
      		 2614 - 3201 (+) 3-isopropylmalate dehydratase small subunit
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        • QVQ62868.1
        • bnvO
        		 3294 - 17414 (-) nonribosomal peptide synthase
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          • QVQ62867.1
          • bnvN
          		 17542 - 18873 (-) tryptophan 7-halogenase
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            • QVQ62866.1
            		 19115 - 19471 (-) tRNA-binding protein
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              • QVQ62865.1
              		 19491 - 20621 (-) DNA polymerase III subunit beta
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                • QVQ62864.1
                • bnvM
                		 20699 - 21361 (-) sugar O-acetyltransferase
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                  • QVQ62863.1
                  • bnvL
                  		 21431 - 22309 (+) pyrroline-5-carboxylate reductase
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                    • QVQ62862.1
                    • bnvK
                    		 22486 - 23670 (+) NAD(P)/FAD-dependent oxidoreductase
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                      • QVQ62861.1
                      • bnvJ
                      		 23724 - 24479 (+) thioesterase
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                        • QVQ62860.1
                        		 24549 - 26690 (+) alpha-ketoacid dehydrogenase subunit alpha/beta
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                          • QVQ62859.1
                          		 26705 - 27742 (+) ketoacyl-ACP synthase III family protein
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                            • QVQ62858.1
                            • bnvI
                            		 27807 - 28583 (-) class I SAM-dependent methyltransferase
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                              • QVQ62857.1
                              • bnvH
                              		 28610 - 30388 (-) AMP-binding protein
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                                • QVQ62851.1
                                • bnvG
                                		 30390 - 31652 (-) cytochrome P450
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                                  • QVQ62856.1
                                  • bnvF
                                  		 31649 - 33472 (-) nonribosomal peptide synthase
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                                    • QVQ62850.1
                                    • bnvE
                                    		 33469 - 34224 (-) thioesterase
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                                      • QVQ62849.1
                                      		 34284 - 34502 (-) MbtH family protein
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                                        • QVQ62855.1
                                        • bnvD
                                        		 34661 - 45328 (-) nonribosomal peptide synthase
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                                          • QVQ62848.1
                                          		 45463 - 46284 (-) hypothetical protein
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                                            • QVQ62847.1
                                            • bnvC
                                            		 46305 - 48059 (-) radical SAM protein
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                                              • QVQ62846.1
                                              		 48638 - 50524 (+) HAD-IIIC family phosphatase
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                                                • QVQ62845.1
                                                • bnvB
                                                		 50521 - 50760 (+) acyl carrier protein
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                                                  • QVQ62854.1
                                                  		 50757 - 52043 (+) cation:proton antiporter
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                                                    • QVQ62844.1
                                                    		 52209 - 52844 (-) pyridoxamine 5'-phosphate oxidase family protein
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                                                      • QVQ62843.1
                                                      		 52841 - 54076 (-) amidohydrolase
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                                                        • QVQ62853.1
                                                        • bnvA
                                                        		 54073 - 55137 (-) methyltransferase domain-containing protein
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                                                          • QVQ62842.1
                                                          		 55134 - 56006 (-) 4'-phosphopantetheinyl transferase superfamily protein
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                                                            • QVQ62852.1
                                                            		 56021 - 56944 (-) EamA family transporter
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                                                              Biosynthesis information

                                                              No biosynthesis information available for this record.

                                                              Annotation changelog

                                                              Entry version: 3

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2024-04-23
                                                              MIBiG v4 annotathon
                                                              • (ID: D4PT7DYQL5DZKSW73RASEGB6)
                                                              • (ID: CVBS4CX3MGQ2Y6Q45INSO263)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                              Entry version: 2

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2022-10-07
                                                              Added chemical structures for compounds: bonnevillamide D, bonnevillamide E.
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              2022-10-07
                                                              Added NPAtlas links to compounds: bonnevillamide D, bonnevillamide E.
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                              Entry version: 1

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2022-09-15
                                                              Entry added
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              2022-09-15
                                                              Added NRP substrate specificities
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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