BGC0002441: (2E,4E,6E,8E)-N-(2-hydroxy-5-oxocyclopent-1-en-1-yl)-9-(o-tolyl)nona-2,4,6,8-tetraenamide biosynthetic gene cluster from Streptomyces sp. SANK 60404
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Location: 1 - 28,832 nt. (total: 28,832 nt).
This entry is originally from NCBI GenBank LC595634.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
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Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002441
Short description (2E,4E,6E,8E)-N-(2-hydroxy-5-oxocyclopent-1-en-1-yl)-9-(o-tolyl)nona-2,4,6,8-tetraenamide biosynthetic gene cluster from Streptomyces sp. SANK 60404
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
  • NRPS (Type I)
Loci
LC595634.1
1 - 28832
via Knock-out studies, Enzymatic assays
Compounds
  • (2E,4E,6E,8E)-N-(2-hydroxy-5-oxocyclopent-1-en-1-yl)-9-(o-tolyl)nona-2,4,6,8-tetraenamide
  • (E)-N-(2-hydroxy-5-oxocyclopent-1-en-1-yl)-5-(o-tolyl)pent-4-enamide
Species Streptomyces sp. SANK 60404 [taxonomy]
References
Chemical products information
(2E,4E,6E,8E)-N-(2-hydroxy-5-oxocyclopent-1-en-1-yl)-9-(o-tolyl)nona-2,4,6,8-tetraenamide Evidence: Mass spectrometry [1]
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C21H21N1O3
(E)-N-(2-hydroxy-5-oxocyclopent-1-en-1-yl)-5-(o-tolyl)pent-4-enamide Evidence: Mass spectrometry [1]
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C17H19N1O3
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BCN28618.1
  • mbg0
 1 - 930 (-) ACP S-malonyltransferase
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    • BCN28619.1
    • orf5
    		 1193 - 1969 (-) LuxR family transcriptional regulator
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      • BCN28620.1
      • orf4
      		 1966 - 2847 (-) response regulator transcription factor
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        • BCN28621.1
        • orf3
        		 3954 - 6722 (+) non-ribosomal peptide synthetase
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          • BCN28622.1
          • orf2
          		 6719 - 7651 (+) NAD-dependent epimerase/dehydratase family
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            • BCN28623.1
            • orf1
            		 7659 - 8063 (+) nuclear transport factor 2 family
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              • BCN28624.1
              • mbg1
              		 8159 - 8929 (-) 4'-phosphopantetheinyl transferase
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                • BCN28625.1
                • mbg2
                		 9039 - 9716 (-) isomerase
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                  • BCN28626.1
                  • mbg3
                  		 9762 - 10865 (-) 3-oxoacyl-ACP synthase
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                    • BCN28627.1
                    • mbg4
                    		 10871 - 11740 (-) alpha/beta hydrolase
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                      • BCN28628.1
                      • mbg5
                      		 11742 - 12701 (-) 3-oxoacyl-ACP synthase
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                        • BCN28629.1
                        • mbg6
                        		 12698 - 13837 (-) 3-oxoacyl-ACP synthase
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                          • BCN28630.1
                          • mbg7
                          		 13831 - 15123 (-) 3-oxoacyl-ACP synthase
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                            • BCN28631.1
                            • mbg8
                            		 15186 - 15440 (-) acyl-carrier protein
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                              • BCN28632.1
                              • mbg9
                              		 15614 - 16546 (-) 3-hydroxyacyl-ACP dehydratase
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                                • BCN28633.1
                                • mbg10
                                		 16543 - 16791 (-) acyl-carrier protein
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                                  • BCN28634.1
                                  • mbg11
                                  		 16826 - 17851 (-) SDR family oxidoreductase
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                                    • BCN28635.1
                                    • mbg12
                                    		 17898 - 18347 (-) SRPBCC family protein
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                                      • BCN28636.1
                                      • mbg13
                                      		 18459 - 20081 (-) MFS transporter
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                                        • BCN28637.1
                                        • mbg14
                                        		 20139 - 20387 (-) acyl-carrier protein
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                                          • BCN28638.1
                                          • mbg15
                                          		 20430 - 21401 (-) 3-oxoacyl-ACP synthase
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                                            • BCN28639.1
                                            • mbg16
                                            		 21398 - 22564 (-) 3-oxoacyl-ACP synthase
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                                              • BCN28640.1
                                              • mbg17
                                              		 22809 - 23798 (+) putative thioesterase
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                                                • BCN28641.1
                                                • mbg18
                                                		 23804 - 24130 (+) DsrE family protein
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                                                  • BCN28642.1
                                                  • mbg19
                                                  		 24130 - 24534 (+) hypothetical protein
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                                                    • BCN28643.1
                                                    • mbg20
                                                    		 24536 - 24913 (+) hypothetical protein
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                                                      • BCN28644.1
                                                      • mbg21
                                                      		 24982 - 26166 (+) 3-oxoacyl-ACP synthase
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                                                        • BCN28645.1
                                                        • mbg22
                                                        		 26163 - 27146 (+) 3-oxoacyl-ACP synthase
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                                                          • BCN28646.1
                                                          • mbg23
                                                          		 27180 - 27566 (+) 3-hydroxyacyl-ACP dehydratase
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                                                            • BCN28647.1
                                                            • mbg24
                                                            		 27563 - 28078 (+) 3-hydroxyacyl-ACP dehydratase
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                                                              • BCN28648.1
                                                              • mbg25
                                                              		 28071 - 28832 (+) 3-oxoacyl-ACP reductase
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                                                                Biosynthesis information

                                                                No biosynthesis information available for this record.

                                                                Annotation changelog

                                                                Entry version: 2

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2024-04-23
                                                                MIBiG v4 annotathon
                                                                • (ID: OCE3JJUWNMF4OVBLYXWCZ36L)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 1

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2022-09-15
                                                                Entry added
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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