BGC0002479: miharamycin B biosynthetic gene cluster from Streptomyces miharaensis
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Location: 1 - 43,827 nt. (total: 43,827 nt).
This entry is originally from NCBI GenBank MN850873.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002479
Short description miharamycin B biosynthetic gene cluster from Streptomyces miharaensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
  • NRPS (Type I)
  • saccharide (None)
Loci
MN850873.1
1 - 43827
via Heterologous expression
Compounds
  • miharamycin B
  • miharamycin A
Species Streptomyces miharaensis [taxonomy]
References
Chemical products information
miharamycin B Evidence:
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Chemical database entries
NPAtlas
miharamycin A Evidence:
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Chemical database entries
NPAtlas
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QHD26299.1
  • mihR1
 4853 - 5551 (+) TetR/AcrR family transcriptional regulator
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    • QHD26301.1
    • mihL
    		 5535 - 6224 (-) YqcI/YcgG family protein
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      • QHD26300.1
      • mihM
      		 6221 - 8230 (-) phenylalanyl-tRNA synthetase beta chain
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        • QHD26302.1
        • mihN
        		 8227 - 9072 (-) phenylalanyl-tRNA synthetase alpha chain
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          • QHD26303.1
          • mihO
          		 9077 - 9808 (-) SAM-dependent methyltransferase
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            • QHD26304.1
            • mihA
            		 9880 - 11118 (-) ATP-grasp domain-containing protein
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              • QHD26305.1
              • mihP
              		 11183 - 11743 (-) 4'-phosphopantetheinyl transferase
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                • QHD26306.1
                • mihR3
                		 12010 - 13284 (-) MFS superfamily transporter
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                  • QHD26307.1
                  • mihD
                  		 13306 - 13899 (-) TIGR00730 family Rossman fold protein
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                    • QHD26308.1
                    • mihE
                    		 13886 - 14620 (-) SDR family oxidoreductase
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                      • QHD26309.1
                      • mihF
                      		 14620 - 15243 (-) SAM-dependent methyltransferase
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                        • QHD26310.1
                        • mihB1
                        		 15240 - 16376 (-) FkbH-like protein
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                          • QHD26311.1
                          • mihB2
                          		 16363 - 17547 (-) acyl-CoA dehydrogenase
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                            • QHD26312.1
                            • mihB3
                            		 17544 - 17837 (-) acyl carrier protein
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                              • QHD26314.1
                              • mihB4
                              		 17841 - 18686 (-) 3-hydroxybutyryl-CoA dehydrogenase
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                                • QHD26313.1
                                • mihB5
                                		 18683 - 21769 (-) polyketide synthase
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                                  • QHD26315.1
                                  • mihB6
                                  		 21766 - 24204 (-) non-ribosomal peptide synthetase
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                                    • QHD26316.1
                                    • mihG
                                    		 24204 - 25691 (-) FAD-dependent oxidoreductase
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                                      • QHD26317.1
                                      • mihH
                                      		 25684 - 26724 (-) hypothetical protein
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                                        • QHD26318.1
                                        • mihI
                                        		 26721 - 27977 (-) hypothetical protein
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                                          • QHD26319.1
                                          • mihC1
                                          		 27980 - 28927 (-) transketolase
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                                            • QHD26320.1
                                            • mihC2
                                            		 28924 - 29760 (-) transketolase
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                                              • QHD26321.1
                                              • mihK
                                              		 30013 - 31107 (+) gfo/Idh/MocA family oxidoreductase
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                                                • QHD26322.1
                                                • mihQ
                                                		 31114 - 31938 (+) Subunit A of Class III Extradiol ring-cleavage dioxygenase
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                                                  • QHD26323.1
                                                  • mihS
                                                  		 32026 - 32322 (+) Subunit B of Class III Extradiol ring-cleavage dioxygenase
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                                                    • QHD26324.1
                                                    • mihJ
                                                    		 32291 - 33196 (-) ranched-chain amino acid aminotransferase
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                                                      • QHD26325.1
                                                      • mihT
                                                      		 33346 - 34653 (-) alanyl-tRNA synthetase
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                                                        • QHD26326.1
                                                        • mihR2
                                                        		 35228 - 36571 (-) XRE family transcriptional regulator
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                                                          Biosynthesis information

                                                          No biosynthesis information available for this record.

                                                          Annotation changelog

                                                          Entry version: 2

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-10-07
                                                          Changed chemical structures for compounds: miharamycin A.
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-10-07
                                                          Added chemical structures for compounds: miharamycin B.
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-10-07
                                                          Added NPAtlas links to compounds: miharamycin B.
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 1

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-09-15
                                                          Entry added
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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