BGC0002654: lapcin biosynthetic gene cluster from uncultured bacterium
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Location: 1 - 49,405 nt. (total: 49,405 nt).
This entry is originally from NCBI GenBank MZ165589.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002654
Short description lapcin biosynthetic gene cluster from uncultured bacterium
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MZ165589.1
1 - 49405
via
Compounds
  • lapcin
Species uncultured bacterium [taxonomy]
References
Chemical products information
lapcin Evidence:
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C64H77N11O15S2
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • UHJ79941.1
 1 - 837 (+) pentapeptide repeat protein
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    • UHJ79942.1
    		 770 - 3352 (-) non-ribosomal peptide synthetase
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      • UHJ79943.1
      		 3658 - 5535 (-) radical SAM protein
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        • UHJ79944.1
        		 5611 - 6789 (-) benzoyl-coA 2,3-epoxidase
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          • UHJ79945.1
          		 7066 - 7545 (-) DUF1579 domain-containing protein
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            • UHJ79946.1
            		 7769 - 8725 (+) alpha/beta hydrolase
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              • UHJ79947.1
              		 8722 - 9759 (+) methyltransferase domain-containing protein
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                • UHJ79948.1
                		 9770 - 15682 (+) non-ribosomal peptide synthetase
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                  • UHJ79949.1
                  		 15679 - 16869 (+) flavin-dependent dehydrogenase
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                    • UHJ79950.1
                    		 16866 - 17666 (-) thioesterase
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                      • UHJ79951.1
                      		 18087 - 34397 (+) non-ribosomal peptide synthetase
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                        • UHJ79952.1
                        		 34358 - 36454 (+) non-ribosomal peptide synthetase
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                          • UHJ79953.1
                          		 36488 - 45952 (+) non-ribosomal peptide synthetase
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                            • UHJ79954.1
                            		 45990 - 46193 (-) MbtH family NRPS accessory protein
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                              • UHJ79955.1
                              		 46224 - 47120 (-) branched-chain amino acid aminotransferase
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                                • UHJ79956.1
                                		 47213 - 49405 (-) aminodeoxychorismate synthase component I
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                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  UHJ79948.1
                                  Substrates
                                  4-amino-2-hydroxy-3-isopropoxybenzoic acid (evidence: Sequence-based prediction [1])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk02
                                  Type
                                  nrps-type1
                                  Genes
                                  UHJ79948.1
                                  Substrates
                                  para-aminobenzoic acid (evidence: Sequence-based prediction [1])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk03
                                  Type
                                  nrps-type1
                                  Genes
                                  UHJ79951.1
                                  Substrates
                                  para-aminobenzoic acid (evidence: Sequence-based prediction [1])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk04
                                  Type
                                  nrps-type1
                                  Genes
                                  UHJ79951.1
                                  Substrates
                                  cysteine (evidence: Sequence-based prediction [1])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk05
                                  Type
                                  nrps-type1
                                  Genes
                                  UHJ79951.1
                                  Substrates
                                  cysteine (evidence: Sequence-based prediction [1])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk06
                                  Type
                                  nrps-type1
                                  Genes
                                  UHJ79951.1
                                  Substrates
                                  asparagine (evidence: Sequence-based prediction [1])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk07
                                  Type
                                  nrps-type1
                                  Genes
                                  UHJ79951.1
                                  Substrates
                                  para-aminobenzoic acid (evidence: Sequence-based prediction [1])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk08
                                  Type
                                  nrps-type1
                                  Genes
                                  UHJ79953.1
                                  Substrates
                                  alanine (evidence: Sequence-based prediction [1])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk09
                                  Type
                                  nrps-type1
                                  Genes
                                  UHJ79953.1
                                  Substrates
                                  serine (evidence: Sequence-based prediction [1])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk10
                                  Type
                                  nrps-type1
                                  Genes
                                  UHJ79953.1
                                  Substrates
                                  alanine (evidence: Sequence-based prediction [1])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2024-03-19
                                  MIBiG v4 annotathon
                                  • (ID: 3OFRGD3XQY2W5RRQYRWHG5KI)
                                  • (ID: D5UIALNVPDWCMADVVDHBCS3X)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Entry added
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Added NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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