BGC0002676: skyllamycin D biosynthetic gene cluster from Streptomyces anulatus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 4,359,372 - 4,488,594 nt. (total: 129,223 nt).
This entry is originally from NCBI GenBank CP080029.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002676
Short description skyllamycin D biosynthetic gene cluster from Streptomyces anulatus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP080029.1
4360500 - 4484678
via
Compounds
  • skyllamycin D
  • skyllamycin E
Species Streptomyces anulatus [taxonomy]
References
Chemical products information
skyllamycin D Evidence:
(no structure information available)
skyllamycin E Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • KZO11_19295
  • QYA95646.1
 4360500 - 4360772 (-) DUF1876 domain-containing protein
    copy AA seq
    copy Nt seq
    • KZO11_19300
    • QYA95647.1
    		 4360806 - 4361687 (-) diacylglycerol kinase
      copy AA seq
      copy Nt seq
      • KZO11_19305
      • QYA95648.1
      		 4361873 - 4363156 (+) adenylosuccinate synthase
        copy AA seq
        copy Nt seq
        • KZO11_19310
        • QYA95649.1
        		 4363462 - 4364916 (-) MFS transporter
          copy AA seq
          copy Nt seq
          • KZO11_19315
          • QYA99269.1
          		 4365527 - 4365877 (+) helix-turn-helix transcriptional regulator
            copy AA seq
            copy Nt seq
            • KZO11_19320
            • QYA95650.1
            		 4365940 - 4366668 (+) TetR/AcrR family transcriptional regulator
              copy AA seq
              copy Nt seq
              • KZO11_19325
              • QYA95651.1
              		 4367060 - 4368499 (+) MFS transporter
                copy AA seq
                copy Nt seq
                • KZO11_19330
                • QYA95652.1
                		 4368538 - 4370328 (+) ABC transporter ATP-binding protein/permease
                  copy AA seq
                  copy Nt seq
                  • KZO11_19335
                  • QYA99270.1
                  		 4370413 - 4372092 (+) ABC transporter ATP-binding protein/permease
                    copy AA seq
                    copy Nt seq
                    • KZO11_19340
                    • QYA95653.1
                    		 4372134 - 4372928 (-) alpha/beta hydrolase
                      copy AA seq
                      copy Nt seq
                      • KZO11_19345
                      • QYA95654.1
                      		 4372962 - 4374149 (-) acyl-CoA/acyl-ACP dehydrogenase
                        copy AA seq
                        copy Nt seq
                        • KZO11_19350
                        • QYA95655.1
                        		 4374276 - 4375427 (-) acyl-CoA dehydrogenase
                          copy AA seq
                          copy Nt seq
                          • KZO11_19355
                          • QYA95656.1
                          		 4375424 - 4375702 (-) acyl carrier protein
                            copy AA seq
                            copy Nt seq
                            • KZO11_19360
                            • QYA95657.1
                            		 4375686 - 4377239 (-) amino acid adenylation domain-containing protein
                              copy AA seq
                              copy Nt seq
                              • KZO11_19365
                              • QYA95658.1
                              		 4377236 - 4378867 (-) AMP-binding protein
                                copy AA seq
                                copy Nt seq
                                • KZO11_19370
                                • QYA95659.1
                                		 4379372 - 4382914 (+) amino acid adenylation domain-containing protein
                                  copy AA seq
                                  copy Nt seq
                                  • KZO11_19375
                                  • QYA95660.1
                                  		 4383034 - 4384443 (+) hypothetical protein
                                    copy AA seq
                                    copy Nt seq
                                    • KZO11_19380
                                    • QYA95661.1
                                    		 4384560 - 4385270 (+) YqcI/YcgG family protein
                                      copy AA seq
                                      copy Nt seq
                                      • KZO11_19385
                                      • QYA95662.1
                                      		 4385263 - 4388721 (+) amino acid adenylation domain-containing protein
                                        copy AA seq
                                        copy Nt seq
                                        • KZO11_19390
                                        • QYA95663.1
                                        		 4388718 - 4393034 (+) acyltransferase domain-containing protein
                                          copy AA seq
                                          copy Nt seq
                                          • KZO11_19395
                                          • QYA95664.1
                                          		 4393031 - 4394050 (+) hypothetical protein
                                            copy AA seq
                                            copy Nt seq
                                            • KZO11_19400
                                            • QYA99271.1
                                            		 4394286 - 4394777 (+) flavin reductase family protein
                                              copy AA seq
                                              copy Nt seq
                                              • KZO11_19405
                                              • QYA95665.1
                                              		 4394997 - 4395818 (+) chitinase
                                                copy AA seq
                                                copy Nt seq
                                                • KZO11_19410
                                                • QYA95666.1
                                                		 4396123 - 4397007 (+) chitinase
                                                  copy AA seq
                                                  copy Nt seq
                                                  • KZO11_19415
                                                  • QYA95667.1
                                                  • dnaN
                                                  		 4397125 - 4398240 (-) DNA polymerase III subunit beta
                                                    copy AA seq
                                                    copy Nt seq
                                                    • KZO11_19420
                                                    • QYA99272.1
                                                    		 4398619 - 4400091 (+) helix-turn-helix domain-containing protein
                                                      copy AA seq
                                                      copy Nt seq
                                                      • KZO11_19425
                                                      • QYA99273.1
                                                      		 4401260 - 4402003 (+) LuxR family transcriptional regulator
                                                        copy AA seq
                                                        copy Nt seq
                                                        • KZO11_19430
                                                        • QYA99274.1
                                                        		 4402223 - 4402990 (+) LuxR family transcriptional regulator
                                                          copy AA seq
                                                          copy Nt seq
                                                          • KZO11_19435
                                                          • QYA95668.1
                                                          		 4403231 - 4404085 (+) helix-turn-helix domain-containing protein
                                                            copy AA seq
                                                            copy Nt seq
                                                            • KZO11_19440
                                                            • QYA95669.1
                                                            		 4404114 - 4406057 (+) transcriptional regulator
                                                              copy AA seq
                                                              copy Nt seq
                                                              • KZO11_19445
                                                              • QYA95670.1
                                                              		 4406204 - 4406413 (-) hypothetical protein
                                                                copy AA seq
                                                                copy Nt seq
                                                                • KZO11_19450
                                                                • QYA99275.1
                                                                		 4406803 - 4407510 (+) helix-turn-helix domain-containing protein
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  • KZO11_19455
                                                                  • QYA99276.1
                                                                  		 4407773 - 4408057 (+) LysR family transcriptional regulator
                                                                    copy AA seq
                                                                    copy Nt seq
                                                                    • KZO11_19460
                                                                    • QYA99277.1
                                                                    		 4408189 - 4408638 (+) cobalamin-dependent protein
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • KZO11_19465
                                                                      • QYA95671.1
                                                                      		 4408635 - 4409951 (+) methylaspartate mutase
                                                                        copy AA seq
                                                                        copy Nt seq
                                                                        • KZO11_19470
                                                                        • QYA95672.1
                                                                        		 4410043 - 4410567 (-) flavin reductase family protein
                                                                          copy AA seq
                                                                          copy Nt seq
                                                                          • KZO11_19475
                                                                          • QYA95673.1
                                                                          		 4410646 - 4411716 (-) LLM class flavin-dependent oxidoreductase
                                                                            copy AA seq
                                                                            copy Nt seq
                                                                            • KZO11_19480
                                                                            • QYA95674.1
                                                                            		 4411801 - 4412595 (-) ABC transporter permease
                                                                              copy AA seq
                                                                              copy Nt seq
                                                                              • KZO11_19485
                                                                              • QYA95675.1
                                                                              		 4412609 - 4413760 (-) methyltransferase domain-containing protein
                                                                                copy AA seq
                                                                                copy Nt seq
                                                                                • KZO11_19490
                                                                                • QYA95676.1
                                                                                		 4413807 - 4414595 (-) ABC transporter permease
                                                                                  copy AA seq
                                                                                  copy Nt seq
                                                                                  • KZO11_19495
                                                                                  • QYA95677.1
                                                                                  		 4414592 - 4415569 (-) ATP-binding cassette domain-containing protein
                                                                                    copy AA seq
                                                                                    copy Nt seq
                                                                                    • KZO11_19500
                                                                                    • QYA95678.1
                                                                                    		 4415834 - 4416490 (+) DUF3995 domain-containing protein
                                                                                      copy AA seq
                                                                                      copy Nt seq
                                                                                      • KZO11_19505
                                                                                      • QYA99278.1
                                                                                      		 4416510 - 4417175 (-) alpha/beta fold hydrolase
                                                                                        copy AA seq
                                                                                        copy Nt seq
                                                                                        • KZO11_19510
                                                                                        • QYA95679.1
                                                                                        		 4417280 - 4418551 (-) cytochrome P450
                                                                                          copy AA seq
                                                                                          copy Nt seq
                                                                                          • KZO11_19515
                                                                                          • QYA95680.1
                                                                                          		 4418591 - 4430317 (-) amino acid adenylation domain-containing protein
                                                                                            copy AA seq
                                                                                            copy Nt seq
                                                                                            • KZO11_19520
                                                                                            • QYA95681.1
                                                                                            		 4430311 - 4444497 (-) amino acid adenylation domain-containing protein
                                                                                              copy AA seq
                                                                                              copy Nt seq
                                                                                              • KZO11_19525
                                                                                              • QYA95682.1
                                                                                              		 4444494 - 4458737 (-) amino acid adenylation domain-containing protein
                                                                                                copy AA seq
                                                                                                copy Nt seq
                                                                                                • KZO11_19530
                                                                                                • QYA95683.1
                                                                                                		 4458916 - 4460583 (-) NAD(P)/FAD-dependent oxidoreductase
                                                                                                  copy AA seq
                                                                                                  copy Nt seq
                                                                                                  • KZO11_19535
                                                                                                  • QYA95684.1
                                                                                                  		 4460681 - 4461391 (-) DsbA family protein
                                                                                                    copy AA seq
                                                                                                    copy Nt seq
                                                                                                    • KZO11_19540
                                                                                                    • QYA95685.1
                                                                                                    • fabG
                                                                                                    		 4461433 - 4462179 (-) 3-oxoacyl-[acyl-carrier-protein] reductase
                                                                                                      copy AA seq
                                                                                                      copy Nt seq
                                                                                                      • KZO11_19545
                                                                                                      • QYA95686.1
                                                                                                      		 4462201 - 4462689 (-) beta-hydroxyacyl-ACP dehydratase
                                                                                                        copy AA seq
                                                                                                        copy Nt seq
                                                                                                        • KZO11_19550
                                                                                                        • QYA95687.1
                                                                                                        		 4462686 - 4463132 (-) hypothetical protein
                                                                                                          copy AA seq
                                                                                                          copy Nt seq
                                                                                                          • KZO11_19555
                                                                                                          • QYA99279.1
                                                                                                          		 4463129 - 4463377 (-) acyl carrier protein
                                                                                                            copy AA seq
                                                                                                            copy Nt seq
                                                                                                            • KZO11_19560
                                                                                                            • QYA95688.1
                                                                                                            		 4463437 - 4464540 (-) 3-oxoacyl-ACP synthase
                                                                                                              copy AA seq
                                                                                                              copy Nt seq
                                                                                                              • KZO11_19565
                                                                                                              • QYA95689.1
                                                                                                              		 4464569 - 4465609 (-) thioesterase family protein
                                                                                                                copy AA seq
                                                                                                                copy Nt seq
                                                                                                                • KZO11_19570
                                                                                                                • QYA95690.1
                                                                                                                		 4465615 - 4466505 (-) alpha/beta hydrolase
                                                                                                                  copy AA seq
                                                                                                                  copy Nt seq
                                                                                                                  • KZO11_19575
                                                                                                                  • QYA95691.1
                                                                                                                  		 4466502 - 4467464 (-) 3-oxoacyl-ACP synthase
                                                                                                                    copy AA seq
                                                                                                                    copy Nt seq
                                                                                                                    • KZO11_19580
                                                                                                                    • QYA95692.1
                                                                                                                    		 4467461 - 4468594 (-) 3-oxoacyl-ACP synthase
                                                                                                                      copy AA seq
                                                                                                                      copy Nt seq
                                                                                                                      • KZO11_19585
                                                                                                                      • QYA95693.1
                                                                                                                      		 4468591 - 4469847 (-) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
                                                                                                                        copy AA seq
                                                                                                                        copy Nt seq
                                                                                                                        • KZO11_19590
                                                                                                                        • QYA95694.1
                                                                                                                        		 4469900 - 4470154 (-) acyl carrier protein
                                                                                                                          copy AA seq
                                                                                                                          copy Nt seq
                                                                                                                          • KZO11_19595
                                                                                                                          • QYA95695.1
                                                                                                                          		 4470588 - 4470809 (+) MbtH family protein
                                                                                                                            copy AA seq
                                                                                                                            copy Nt seq
                                                                                                                            • KZO11_19600
                                                                                                                            • QYA95696.1
                                                                                                                            		 4470900 - 4472861 (-) AarF/ABC1/UbiB kinase family protein
                                                                                                                              copy AA seq
                                                                                                                              copy Nt seq
                                                                                                                              • KZO11_19605
                                                                                                                              • QYA95697.1
                                                                                                                              		 4472917 - 4473834 (-) ACP S-malonyltransferase
                                                                                                                                copy AA seq
                                                                                                                                copy Nt seq
                                                                                                                                • KZO11_19610
                                                                                                                                • QYA95698.1
                                                                                                                                		 4474474 - 4475517 (+) polyprenyl synthetase family protein
                                                                                                                                  copy AA seq
                                                                                                                                  copy Nt seq
                                                                                                                                  • KZO11_19615
                                                                                                                                  • QYA95699.1
                                                                                                                                  		 4475547 - 4477094 (+) acyl-CoA carboxylase subunit beta
                                                                                                                                    copy AA seq
                                                                                                                                    copy Nt seq
                                                                                                                                    • KZO11_19620
                                                                                                                                    • QYA95700.1
                                                                                                                                    		 4477091 - 4477303 (+) acyl-CoA carboxylase subunit epsilon
                                                                                                                                      copy AA seq
                                                                                                                                      copy Nt seq
                                                                                                                                      • KZO11_19625
                                                                                                                                      • QYA95701.1
                                                                                                                                      		 4477341 - 4478777 (-) FG-GAP repeat protein
                                                                                                                                        copy AA seq
                                                                                                                                        copy Nt seq
                                                                                                                                        • KZO11_19630
                                                                                                                                        • QYA95702.1
                                                                                                                                        		 4478870 - 4479106 (-) DUF397 domain-containing protein
                                                                                                                                          copy AA seq
                                                                                                                                          copy Nt seq
                                                                                                                                          • KZO11_19635
                                                                                                                                          • QYA95703.1
                                                                                                                                          		 4479103 - 4479939 (-) helix-turn-helix transcriptional regulator
                                                                                                                                            copy AA seq
                                                                                                                                            copy Nt seq
                                                                                                                                            • KZO11_19640
                                                                                                                                            • QYA95704.1
                                                                                                                                            		 4480096 - 4480503 (+) hypothetical protein
                                                                                                                                              copy AA seq
                                                                                                                                              copy Nt seq
                                                                                                                                              • KZO11_19645
                                                                                                                                              • QYA95705.1
                                                                                                                                              		 4480492 - 4481109 (-) GNAT family N-acetyltransferase
                                                                                                                                                copy AA seq
                                                                                                                                                copy Nt seq
                                                                                                                                                • KZO11_19650
                                                                                                                                                • QYA95706.1
                                                                                                                                                		 4481334 - 4481990 (+) DsbA family oxidoreductase
                                                                                                                                                  copy AA seq
                                                                                                                                                  copy Nt seq
                                                                                                                                                  • KZO11_19655
                                                                                                                                                  • QYA95707.1
                                                                                                                                                  		 4482037 - 4483122 (+) NADH:flavin oxidoreductase
                                                                                                                                                    copy AA seq
                                                                                                                                                    copy Nt seq
                                                                                                                                                    • KZO11_19660
                                                                                                                                                    • QYA95708.1
                                                                                                                                                    		 4483273 - 4483752 (+) nucleoside deaminase
                                                                                                                                                      copy AA seq
                                                                                                                                                      copy Nt seq
                                                                                                                                                      • KZO11_19665
                                                                                                                                                      • QYA95709.1
                                                                                                                                                      		 4483844 - 4484164 (+) multidrug efflux SMR transporter
                                                                                                                                                        copy AA seq
                                                                                                                                                        copy Nt seq
                                                                                                                                                        • KZO11_19670
                                                                                                                                                        • QYA95710.1
                                                                                                                                                        		 4484265 - 4484678 (+) multidrug efflux SMR transporter
                                                                                                                                                          copy AA seq
                                                                                                                                                          copy Nt seq
                                                                                                                                                          Biosynthesis information

                                                                                                                                                          No biosynthesis information available for this record.

                                                                                                                                                          Annotation changelog

                                                                                                                                                          Entry version: 1

                                                                                                                                                          Date
                                                                                                                                                          Changes
                                                                                                                                                          Submitters
                                                                                                                                                          Reviewers
                                                                                                                                                          2022-09-15
                                                                                                                                                          Entry added
                                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                          Similar known clusters from MIBiG 4.0
                                                                                                                                                          Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                                                                                                          Detailed help and explanations are available here.

                                                                                                                                                          Click on reference genes to show details of similarities to genes within the current region.
                                                                                                                                                          Double click on a reference drawing to reverse the display of the genes.

                                                                                                                                                          Click on an accession to open that entry in the MIBiG database.


                                                                                                                                                          Location:

                                                                                                                                                          Identifier
                                                                                                                                                          Identity
                                                                                                                                                          Coverage
                                                                                                                                                          Detailed domain annotation
                                                                                                                                                          Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                                                                                                          A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                                                                                                          Selected features only
                                                                                                                                                          Show module domains