BGC0002718: madurastatin A2 biosynthetic gene cluster from Actinomadura sp. RB99
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Location: 113,472 - 176,364 nt. (total: 62,893 nt).
This entry is originally from NCBI GenBank JABMCA010000006.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002718
Short description madurastatin A2 biosynthetic gene cluster from Actinomadura sp. RB99
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
JABMCA010000006.1
124728 - 156364
via
Compounds
  • madurastatin A2
  • madurastatin E1
  • madurastatin F
  • madurastatin G1
  • madurastatin A1
Species Actinomadura sp. RB99 [taxonomy]
References
Chemical products information
madurastatin A2 Evidence:
(no structure information available)
madurastatin E1 Evidence:
(no structure information available)
madurastatin F Evidence:
(no structure information available)
madurastatin G1 Evidence:
(no structure information available)
madurastatin A1 Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • amrb99_16240
  • MBD2892711.1
  • dmdB_2
 124728 - 126374 (-) 3-methylmercaptopropionyl-CoA ligase
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    • amrb99_16250
    • MBD2892712.1
    		 126412 - 126864 (-) putative enoyl-CoA hydratase 1
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      • amrb99_16260
      • MBD2892713.1
      		 126975 - 128015 (-) hypothetical protein
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        • amrb99_16270
        • MBD2892714.1
        		 128279 - 128620 (+) hypothetical protein
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          • amrb99_16280
          • MBD2892715.1
          		 128664 - 130346 (+) hypothetical protein
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            • amrb99_16290
            • MBD2892716.1
            		 130498 - 130965 (+) hypothetical protein
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              • amrb99_16300
              • MBD2892717.1
              • yfmO_1
              		 130962 - 132230 (+) Multidrug efflux protein YfmO
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                • amrb99_16310
                • MBD2892718.1
                		 132329 - 133201 (+) hypothetical protein
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                  • amrb99_16320
                  • MBD2892719.1
                  • mbtH_1
                  		 133275 - 133472 (-) Protein MbtH
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                    • amrb99_16330
                    • MBD2892720.1
                    • pvdA
                    		 133472 - 134773 (-) L-ornithine N(5)-monooxygenase
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                      • amrb99_16340
                      • MBD2892721.1
                      • fpuA
                      		 134773 - 135789 (-) Petrobactin-binding protein FpuA
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                        • amrb99_16350
                        • MBD2892722.1
                        • dltA_1
                        		 135855 - 147965 (-) D-alanine--D-alanyl carrier protein ligase
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                          • amrb99_16360
                          • MBD2892723.1
                          • mbtI
                          		 148161 - 149471 (+) Salicylate synthase
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                            • amrb99_16370
                            • MBD2892724.1
                            • dhbE
                            		 149534 - 151147 (-) 2,3-dihydroxybenzoate-AMP ligase
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                              • amrb99_16380
                              • MBD2892725.1
                              • panD_1
                              		 151151 - 151558 (-) Aspartate 1-decarboxylase
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                                • amrb99_16390
                                • MBD2892726.1
                                • entS_2
                                		 151637 - 152923 (+) Enterobactin exporter EntS
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                                  • amrb99_16400
                                  • MBD2892727.1
                                  • mbtB
                                  		 152990 - 156364 (-) Phenyloxazoline synthase MbtB
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                                    Biosynthesis information

                                    No biosynthesis information available for this record.

                                    Annotation changelog

                                    Entry version: 2

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2024-08-12
                                    MIBiG v4 annotathon
                                    • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 1

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-09-15
                                    Entry added
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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