Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000001.1:
Cluster 1Polyketide159320

BGC0000001, abyssomicin biosynthetic gene cluster from Verrucosispora maris. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Abyssomicin C
PubChem ID: 71455791
ChEMBL ID: 1651097
SMILES string: Copy to clipboard
Molecular formula: C19H22O6
Exact molecular mass: 346.379 Da (None)
Molecular activity: Antibacterial, Cytotoxic
Molecular target: PabB, p-aminobenzoate (pABA) pathway

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Acetyl-CoA
Thioesterase type:
None
Release / cyclization type:
Macrolactonization

Modular polyketide synthases:
abyB1 (AEK75502.1)
Module 4
AT specificity: Unknown
Evidence for specificity: Unknown
Module 2
AT specificity: Unknown
Evidence for specificity: Unknown
KR stereochemistry: Unknown
Module 3
AT specificity: Acetyl-CoA
Evidence for specificity: Unknown
Module 1
AT specificity: Unknown
Evidence for specificity: Unknown

abyB2 (AEK75503.1)
Module 5
AT specificity: Unknown
Evidence for specificity: Unknown
Module 6
AT specificity: Unknown
Evidence for specificity: Unknown

abyB3 (AEK75504.1)
Module 7
AT specificity: Unknown
Evidence for specificity: Unknown

Gene cluster description

abyssomicin (BGC0000001). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank JF752342. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Daniel Petras (TU Berlin / AK Sussmuth)

Literature references

1. Gottardi EM et al. (2011) Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis. Chembiochem 12(9):1401-10. doi: 10.1002/cbic.201100172.