BGC0000001: abyssomicin C biosynthetic gene cluster from Verrucosispora maris AB-18-032
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Location: 1 - 59,320 nt. (total: 59,320 nt).
This entry is originally from NCBI GenBank JF752342.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000001
Short description abyssomicin C biosynthetic gene cluster from Verrucosispora maris AB-18-032
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: JF752342.1
Compounds
  • abyssomicin C
  • atrop-abyssomicin C
Species Verrucosispora maris AB-18-032 [taxonomy]
References
Chemical products information
abyssomicin C
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C19H22O6
Chemical database entries
NPAtlas
PubCHEM
ChEMBL
atrop-abyssomicin C
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C19H22O6
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEK75490.1
  • orfP
 1 - 1083 (+) protein methyltransferase
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  • AEK75491.1
 1208 - 1834 (+) putative hydrolase
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  • AEK75492.1
  • abyR
 1887 - 2633 (+) pathway-specific SARP activator
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  • AEK75493.1
  • abyX
 2646 - 3836 (-) cytochrome P450
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  • AEK75494.1
  • abyH
 3927 - 6596 (-) LuxR family transcriptional regulator
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  • AEK75495.1
  • abyI
 6952 - 7710 (+) pathway-specific SARP activator
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  • AEK75496.1
  • abyK
 8175 - 10034 (-) YD repeat protein
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  • AEK75497.1
  • abyA1
 10118 - 11143 (+) 3-oxoacyl-ACP synthase III
  • Precursor biosynthesis
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  • AEK75498.1
  • abyA2
 11140 - 13008 (+) phosphatase and glyceryl transferase
  • Activation / processing
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  • AEK75499.1
  • abyA3
 13005 - 13241 (+) acyl-carrier protein
  • Scaffold biosynthesis
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  • AEK75500.1
  • abyA4
 13238 - 13993 (+) pyruvate/2-oxoglutarate dehydrogenase
  • Precursor biosynthesis
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  • AEK75501.1
  • abyA5
 13990 - 15057 (+) AbyA5
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  • AEK75502.1
  • abyB1
 15054 - 32399 (+) type 1 polyketide synthase
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  • AEK75503.1
  • abyB2
 32476 - 43413 (+) type 1 polyketide synthase
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  • AEK75504.1
  • abyB3
 43410 - 46388 (+) type 1 polyketide synthase
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  • AEK75505.1
  • abyC
 46457 - 47149 (-) TetR regulatory protein
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  • AEK75506.1
  • abyD
 47233 - 48660 (+) EmrB/QacA drug resistance transporter
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  • AEK75507.1
  • abyE
 48731 - 49738 (+) luciferase/monooxygenase
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  • AEK75508.1
  • abyF1
 49826 - 51442 (+) BC transporter oligopeptide binding protein
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  • AEK75509.1
  • abyF2
 51439 - 52374 (+) ABC transporter oligopeptide permease
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  • AEK75510.1
  • abyF3
 52371 - 53222 (+) binding-protein dependent ABC transporter
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  • AEK75511.1
  • abyF4
 53212 - 54831 (+) ATP-binding ABC peptide transporter
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  • AEK75512.1
  • abyV
 54828 - 56015 (+) cytochrome P450
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  • AEK75513.1
  • abyW
 55978 - 56229 (+) alcohol dehydrogenase
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  • AEK75514.1
  • abyZ
 56230 - 56808 (-) NAD(P)H-depedent FMN-reductase
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  • AEK75515.1
  • abyT
 56933 - 57829 (+) type II thioesterase
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  • AEK75516.1
  • orfU
 57728 - 58636 (-) Zn-dependent alcohol dehydrogenase
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  • AEK75517.1
  • orfS
 58727 - 59320 (+) TetR transcriptional regulator
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
abyB1
+
abyB2
+
abyB3 		Synthase subclass: Modular type I
Module 1
Genes: abyB1
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 2
Genes: abyB1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Specificity: Acetyl-CoA
Genes: abyB1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Genes: abyB1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Genes: abyB2
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 6
Genes: abyB2
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 7
Genes: abyB3
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: M2JBIQNJAZIP5YVYS7CZLALR, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Sorted modules by module number
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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