BGC0000006 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000006 (Aspergillus flavus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	88,318	aflatoxin B1/aflatoxin B2	PKS	100%

BGC0000006 - Region 1 - T1PKS

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Location: 1 - 88,318 nt. (total: 88,318 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 88,319
Label		BGC0000006

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000006	0.59	Polyketide	aflatoxin	Aspergillus flavus
BGC0000008	0.57	Polyketide	aflatoxin	Aspergillus flavus
BGC0000004	0.54	Polyketide	aflatoxin G1	Aspergillus oryzae
BGC0000007	0.45	Polyketide	aflatoxin	Aspergillus flavus
BGC0000009	0.42	Polyketide	aflatoxin	Aspergillus nomius
BGC0002594	0.29	Polyketide	orcinol, orsellinic acid	Fusarium graminearum PH-1
BGC0002175	0.23	Polyketide	YWA1	Aspergillus oryzae RIB40
BGC0000107	0.22	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002709	0.22	Polyketide	aurofusarin	Fusarium graminearum PH-1
BGC0001542	0.22	Polyketide	cercosporin	Cercospora zeina

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000006	1.00	Polyketide	aflatoxin	Aspergillus flavus
BGC0000008	0.95	Polyketide	aflatoxin	Aspergillus flavus
BGC0000010	0.95	Polyketide	aflatoxin	Aspergillus flavus
BGC0000004	0.94	Polyketide	aflatoxin G1	Aspergillus oryzae
BGC0000007	0.90	Polyketide	aflatoxin	Aspergillus flavus
BGC0000009	0.88	Polyketide	aflatoxin	Aspergillus nomius
BGC0001990	0.70	Other	BU-4704, xanthocillin-X monomethylether, melanocin E, melanocin F, fumiformamide	Aspergillus fumigatus Af293
BGC0001528	0.67	Terpene	betaestacin	Phoma betae
BGC0001605	0.67	Terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001893	0.67	Other	abscisic acid	Botrytis cinerea B05.10

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 43732:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

pksA

PKS_AT (904..1198): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; Methoxymalonyl-CoA: 58.3%; Isobutyryl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 115.5
inactive: 66.2
Methoxymalonyl-CoA: 53.6
Methylmalonyl-CoA: 46.5
Isobutyryl-CoA: 26.8
Propionyl-CoA: 20.6
Acetyl-CoA: 15.5
fatty_acid: 15.4
2-Methylbutyryl-CoA: 14.9
Benzoyl-CoA: 12.3
CHC-CoA: 11.5
Ethylmalonyl-CoA: 10.2
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

AAS90095.1

PKS_AT (138..338): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (1517..1708): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0