BGC0000011 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000011 (Aspergillus ochraceoroseus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	59,535	High	Sterigmatocystin/Aflatoxin B1/Aflatoxin B2	PKS

BGC0000011 - Region 1 - T1PKS

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Location: 1 - 59,535 nt. (total: 59,535 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 59,536
Label		BGC0000011

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

AAM18769.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

ACH72904.1: Reduction

MITE: MITE0000164Reduction (identity: 63.00%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ACH72905.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

ACH72908.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ACH72911.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

ACH72913.2: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

ACI31321.1: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

ACI31322.1: Biaryl bond formation, Reduction

MITE: MITE0000160Biaryl bond formation, Reduction (identity: 67.70%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase methyltransferase sulfotransferase

ACH72896.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

ACH72900.1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

ACH72906.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

ACI31323.1: glutathione S-transferase

smcogs: SMCOG1193: glutathione S-transferase

Hydrolases: hydrolase

ACH72902.1: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Ligases: dehydrogenase synthase

ACH72901.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ACH72912.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ACI31322.1: Biaryl bond formation, Reduction

MITE: MITE0000160Biaryl bond formation, Reduction (identity: 67.70%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000011.3	0.94	PKS	Sterigmatocystin, Aflatoxin B1, Aflatoxin B2	Aspergillus ochraceoroseus
BGC0002175.3	0.68	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.67	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001258.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001284.4	0.67	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.65	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.65	PKS	(-)-Mellein	Parastagonospora nodorum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000011.3	1.00	PKS	Sterigmatocystin, Aflatoxin B1, Aflatoxin B2	Aspergillus ochraceoroseus
BGC0002175.3	0.68	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.67	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001258.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001284.4	0.67	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.65	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.65	PKS	(-)-Mellein	Parastagonospora nodorum

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 37970:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ACH72912.1: mal

PKS_AT (908..1209): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 62.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 117.4
inactive: 64.6
Methoxymalonyl-CoA: 48.9
Methylmalonyl-CoA: 31.8
Isobutyryl-CoA: 19.2
2-Methylbutyryl-CoA: 14.8
Propionyl-CoA: 12.1
CHC-CoA: 10.3
Ethylmalonyl-CoA: 9.0
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

ACH72900.1: pk

PKS_AT (1548..1736): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor