Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000015.1:
Cluster 1Polyketide1113193
The following clusters are from record BGC0000015.2:
Cluster 2Polyketide120832

BGC0000015, amphotericin biosynthetic gene cluster from Streptomyces nodosus. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: amphotericin
PubChem ID: 5386092
SMILES string: Copy to clipboard
Molecular formula: C47H73NO17
Average molecular mass: 924.091 Da

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide synthase subclass:
Type I

Gene cluster description

amphotericin (BGC0000015). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AF357202. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

Literature references

1. Caffrey P et al. (2001) Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes. Chem Biol 8(7):713-23.
2. Carmody M et al. (2005) Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups. J Biol Chem 280(41):34420-6. doi: 10.1074/jbc.M506689200. Epub 2005

BGC0000015, amphotericin biosynthetic gene cluster from Streptomyces nodosus. Locus 2. Partial MIBiG entry.

Chemical compounds

Compound: amphotericin
PubChem ID: 5386092
SMILES string: Copy to clipboard
Molecular formula: C47H73NO17
Average molecular mass: 924.091 Da

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide synthase subclass:
Type I

Gene cluster description

amphotericin (BGC0000015). Gene Cluster 2. Biosynthetic class = Polyketide. GenBank AY639386. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

Literature references

1. Caffrey P et al. (2001) Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes. Chem Biol 8(7):713-23.
2. Carmody M et al. (2005) Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups. J Biol Chem 280(41):34420-6. doi: 10.1074/jbc.M506689200. Epub 2005