BGC0000016: amphotericin B biosynthetic gene cluster from Streptomyces nodosus
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Location: 1 - 5,811 nt. (total: 5,811 nt).
This entry is originally from NCBI GenBank AY636001.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000016
Short description amphotericin B biosynthetic gene cluster from Streptomyces nodosus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: partial
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "This is the sequence of the 5811 base-pair region on the right flank of the amphotericin polyketide synthase genes, adjacent to the amphC gene. It contains genes for a discrete thioesterase (amphE), a non-functional homologue of a transcriptional activator (amphRVI), and an amino acid permease (ORF10)."
Biosynthetic class(es)
  • other (other)
Loci
AY636001.1
via
Compounds
  • amphotericin B
Species Streptomyces nodosus [taxonomy]
References
Chemical products information
amphotericin B Evidence:
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C47H73N1O17
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAV48834.1
 227 - 1090 (+) Discrete thioesterase
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    • AAV48835.1
    		 1484 - 4153 (+) Similar to regulatory protein
    • Regulation
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    • AAV48836.1
    		 4234 - 5727 (-) Amino acid permease
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      Biosynthesis information
      Annotation changelog

      Entry version: 3

      Date
      Changes
      Submitters
      Reviewers
      2022-10-07
      Update chemical activity to schema version 2.11
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 2

      Date
      Changes
      Submitters
      Reviewers
      2019-10-16
      Migrated from v1.4
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 1

      Date
      Changes
      Submitters
      Reviewers
      2015-06-12
      Submitted
      • (ID: Y546CAL2FJSIVXNXJWJNGATV)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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