BGC0000016: amphotericin B biosynthetic gene cluster from Streptomyces nodosus
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Location: 1 - 5,811 nt. (total: 5,811 nt).
This entry is originally from NCBI GenBank AY636001.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000016
Short description amphotericin B biosynthetic gene cluster from Streptomyces nodosus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: incomplete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "This is the sequence of the 5811 base-pair region on the right flank of the amphotericin polyketide synthase genes, adjacent to the amphC gene. It contains genes for a discrete thioesterase (amphE), a non-functional homologue of a transcriptional activator (amphRVI), and an amino acid permease (ORF10)."
Biosynthetic class(es)
  • Other
Loci NCBI GenBank: AY636001.1
Compounds
  • amphotericin B
Species Streptomyces nodosus [taxonomy]
References
Chemical products information
amphotericin B
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C47H73N1O17
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAV48834.1
 227 - 1090 (+) Discrete thioesterase
  • Other enzymatic
Sequence-based prediction
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  • AAV48835.1
 1484 - 4153 (+) Similar to regulatory protein
  • Regulation
Sequence-based prediction
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  • AAV48836.1
 4234 - 5727 (-) Amino acid permease
  • Unknown
Sequence-based prediction
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: Y546CAL2FJSIVXNXJWJNGATV, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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