Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000016.1:
Cluster 1Other15811

BGC0000016, amphotericin biosynthetic gene cluster from Streptomyces nodosus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Amphotericin B
PubChem ID: 5386092
SMILES string: Copy to clipboard
Molecular formula: C47H73NO17
Average molecular mass: 924.091 Da
Molecular activity: Antifungal

Class-specific details

Biosynthetic class(es):
Other biosynthetic class:

Gene cluster description

amphotericin (BGC0000016). Gene Cluster 1. Biosynthetic class = Other. GenBank AY636001. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

General MIBiG information on this cluster

Complete gene cluster sequence?incomplete
Evidence for cluster-compound connection:Sequence-based prediction
Comments:This is the sequence of the 5811 base-pair region on the right flank of the amphotericin polyketide synthase genes, adjacent to the amphC gene. It contains genes for a discrete thioesterase (amphE), a non-functional homologue of a transcriptional activator (amphRVI), and an amino acid permease (ORF10).
Contact for this cluster:Patrick Caffrey (University College Dublin)

Literature references

1. Carmody M et al. (2004) Analysis and manipulation of amphotericin biosynthetic genes by means of modified phage KC515 transduction techniques. Gene 343(1):107-15. doi: 10.1016/j.gene.2004.08.006.