BGC0000017: anatoxin-a biosynthetic gene cluster from [Oscillatoria] sp. PCC 6506
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Location: 1 - 28,910 nt. (total: 28,910 nt).
This entry is originally from NCBI GenBank FJ477836.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000017
Short description anatoxin-a biosynthetic gene cluster from [Oscillatoria] sp. PCC 6506
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
  • other (other)
Loci
FJ477836.1
via Enzymatic assays
Compounds
  • anatoxin-a
  • homoanatoxin-a
Species [Oscillatoria] sp. PCC 6506 [taxonomy]
References
Chemical products information
anatoxin-a Evidence: MS/MS [2]
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C10H15N1O1
Chemical database entries
PubCHEM
CyanoMetDB CyanoMetDB_1772
homoanatoxin-a Evidence: MS/MS [1]
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C11H17N1O1
Chemical database entries
PubCHEM
CyanoMetDB CyanoMetDB_1740
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACR33072.1
 877 - 1596 (+) cyclase-like protein
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    • ACR33073.1
    • anaA
    		 1986 - 2741 (+) thioesterase
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      • ACR33074.1
      • anaB
      		 3652 - 4797 (+) Prolyl-ACP oxidase
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        • ACR33075.1
        • anaC
        		 4810 - 6426 (+) Proline adenylation protein
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          • ACR33076.1
          • anaD
          		 6449 - 6712 (+) Acyl carrier protein
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            • ACR33077.1
            • anaE
            		 6866 - 13306 (+) polyketide synthase
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              • ACR33078.1
              • anaF
              		 13308 - 18905 (+) polyketide synthase
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                • ACR33079.1
                • anaG
                		 19181 - 24082 (+) polyketide synthase
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                  • ACR33080.1
                  • anaH
                  		 24527 - 25009 (+) transposase
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                    • ACR33081.1
                    		 25283 - 25630 (+) putative ATP synthase beta subunit
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                      • ACR33082.1
                      		 25504 - 26589 (-) putative serine/threonine protein kinase
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                        • ACR33083.1
                        		 26759 - 27457 (+) putative SAM-dependent methyltransferase
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                          • ACR33084.1
                          		 27369 - 27713 (+) putative acyl-CoA dehydrogenase
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                            • ACR33085.1
                            		 27485 - 27763 (-) hypothetical conserved protein
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                              • ACR33086.1
                              		 28215 - 28862 (+) putative phosphoglycerate mutase
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                                Biosynthesis information

                                Biosynthetic modules

                                Name
                                1
                                Type
                                pks-modular
                                Genes
                                anaE
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                                Name
                                2
                                Type
                                pks-modular
                                Genes
                                anaF
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                Name
                                3
                                Type
                                pks-modular
                                Genes
                                anaG
                                Substrates
                                Integrated Monomers
                                Domains
                                acyltransferase, ketosynthase, acyltransferase
                                Annotation changelog

                                Entry version: 5

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2024-06-11
                                MIBiG v4 annotathon
                                • (ID: 4ZBJCWV5NZUBDJXCSIV4TKIA)
                                • (ID: AZ5TULIEK5NJ6VTMP7B6DJUW)
                                • (ID: B54ZPFB4PBVBWY2K6JZNBOD5)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 4

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-10-07
                                Update chemical activity to schema version 2.11
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 3

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-09-15
                                Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Added AMP-binding domain substrate specificities
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 2

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2019-10-16
                                Migrated from v1.4
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 1

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2015-06-12
                                Submitted
                                • (ID: GTMWOIPTWIF6ILYNEBGWTDRO)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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