BGC0000018 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000018 (Streptomyces eurythermus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	42,960	niphimycin C/niphimycin D/niphimycin E/17-O-methylniphimycin/niphimycin Iα/19-O-malonylniphimycin	PKS	29%

BGC0000018 - Region 1 - T1PKS

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Location: 1 - 42,960 nt. (total: 42,960 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 42,961
Label		BGC0000018

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000018	1.00	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000166	0.43	Polyketide	tylactone	Streptomyces fradiae
BGC0000041	0.41	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001244	0.34	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001273	0.34	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275	0.33	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000102	0.33	Polyketide	mycinamicin II	Micromonospora griseorubida
BGC0002086	0.32	Polyketide	rosamicin	Micromonospora carbonacea
BGC0000067	0.32	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001163	0.31	Polyketide	1-heptadecene	Moorea producens 3L

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000018	1.00	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000166	0.74	Polyketide	tylactone	Streptomyces fradiae
BGC0000041	0.73	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001244	0.67	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001273	0.67	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275	0.67	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000102	0.66	Polyketide	mycinamicin II	Micromonospora griseorubida
BGC0002086	0.65	Polyketide	rosamicin	Micromonospora carbonacea
BGC0000067	0.65	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001163	0.64	Polyketide	1-heptadecene	Moorea producens 3L

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 42960:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ohmal - Me-ccmal) + (ccmal) + (Me-ccmal) + (Me-ohmal - redemal) + (ohmal)
Non-colinear ordering:: angAI + angAII + angAIV + angAIII + angAV

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

angAI

PKS_AT (595..889): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 222.8
Ethylmalonyl-CoA: 215.6
Methoxymalonyl-CoA: 179.0
2-Methylbutyryl-CoA: 143.1
trans-1,2-CPDA: 126.9
Propionyl-CoA: 106.9
CHC-CoA: 97.5
Malonyl-CoA: 89.5
Isobutyryl-CoA: 85.5
Benzoyl-CoA: 81.0
Acetyl-CoA: 43.3
fatty_acid: 30.8
3-Methylbutyryl-CoA: 30.5
inactive: 25.8

PKS_AT (1594..1888): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 221.1
Ethylmalonyl-CoA: 217.9
Methoxymalonyl-CoA: 177.9
2-Methylbutyryl-CoA: 141.3
trans-1,2-CPDA: 125.9
Propionyl-CoA: 106.9
CHC-CoA: 99.5
Malonyl-CoA: 88.8
Isobutyryl-CoA: 81.0
Benzoyl-CoA: 80.4
Acetyl-CoA: 44.2
fatty_acid: 32.2
3-Methylbutyryl-CoA: 29.2
inactive: 25.5

PKS_AT (3078..3340): mmal

ATSignature: Ethylmalonyl-CoA, Methylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 79.2%; Methylmalonyl-CoA: 79.2%; Methoxymalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 172.4
Methoxymalonyl-CoA: 150.0
Ethylmalonyl-CoA: 134.4
2-Methylbutyryl-CoA: 112.5
trans-1,2-CPDA: 104.6
Propionyl-CoA: 83.6
CHC-CoA: 82.0
Malonyl-CoA: 64.2
Benzoyl-CoA: 51.9
Isobutyryl-CoA: 44.7
Acetyl-CoA: 19.1
inactive: 17.9
fatty_acid: 16.3
3-Methylbutyryl-CoA: 14.1

angAII

PKS_AT (641..983): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 219.5
inactive: 120.8
Methoxymalonyl-CoA: 80.4
Methylmalonyl-CoA: 70.4
Isobutyryl-CoA: 42.3
Ethylmalonyl-CoA: 30.7
Propionyl-CoA: 28.1
Acetyl-CoA: 24.8
Benzoyl-CoA: 19.2
CHC-CoA: 18.6
2-Methylbutyryl-CoA: 17.5
fatty_acid: 13.3
3-Methylbutyryl-CoA: 10.9
trans-1,2-CPDA: 10.6

angAIII

PKS_AT (569..863): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 222.9
Ethylmalonyl-CoA: 214.6
Methoxymalonyl-CoA: 179.8
2-Methylbutyryl-CoA: 149.1
trans-1,2-CPDA: 126.5
Propionyl-CoA: 108.0
CHC-CoA: 95.2
Malonyl-CoA: 89.9
Isobutyryl-CoA: 87.5
Benzoyl-CoA: 78.4
Acetyl-CoA: 44.3
fatty_acid: 33.3
3-Methylbutyryl-CoA: 31.0
inactive: 29.0

PKS_AT (2148..2445): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 234.6
Methylmalonyl-CoA: 207.6
Methoxymalonyl-CoA: 182.0
trans-1,2-CPDA: 159.6
2-Methylbutyryl-CoA: 148.7
Propionyl-CoA: 118.4
CHC-CoA: 107.5
Malonyl-CoA: 83.9
Isobutyryl-CoA: 71.9
Benzoyl-CoA: 61.6
Acetyl-CoA: 56.1
fatty_acid: 46.5
3-Methylbutyryl-CoA: 36.2
inactive: 17.4

angAIV

PKS_AT (557..851): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 222.3
Ethylmalonyl-CoA: 214.0
Methoxymalonyl-CoA: 176.0
2-Methylbutyryl-CoA: 140.7
trans-1,2-CPDA: 121.9
Propionyl-CoA: 103.4
CHC-CoA: 94.7
Malonyl-CoA: 88.3
Benzoyl-CoA: 76.9
Isobutyryl-CoA: 73.9
Acetyl-CoA: 42.7
fatty_acid: 33.5
3-Methylbutyryl-CoA: 23.6
inactive: 21.2

angAV

PKS_AT (599..899): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.4
inactive: 94.0
Methoxymalonyl-CoA: 59.5
Methylmalonyl-CoA: 51.3
Propionyl-CoA: 34.8
Acetyl-CoA: 25.4
Ethylmalonyl-CoA: 19.1
CHC-CoA: 16.7
Isobutyryl-CoA: 14.9
Benzoyl-CoA: 14.0
2-Methylbutyryl-CoA: 12.6
fatty_acid: 10.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0