LOCUS       BGC0000019             18038 bp    DNA     linear   BCT 11-NOV-2007
DEFINITION  Streptomyces eurythermus angolamycin biosynthesis gene cluster,
            complete sequence.
ACCESSION   BGC0000019
VERSION     BGC0000019
KEYWORDS    .
SOURCE      Streptomyces eurythermus
  ORGANISM  Streptomyces eurythermus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 12:33:49
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 18038
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..18038
                     /db_xref="taxon:42237"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces eurythermus"
     subregion       1..18038
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000019"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..18038
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             340..1683
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 136.2; E-value: 2.3e-41)"
                     /gene_kind="biosynthetic-additional"
                     /note="ORF1"
                     /product="NDP-hexose 3,4-isomerase"
                     /protein_id="ABW91149.1"
                     /sec_met_domain="p450 (E-value: 5.5e-08, bitscore: 21.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPAPATEDPAAAGRRLQLTRAAQWFAGTQDDPYALVLRAEATDP
                     APYEERIRAHGPLFRSDLLDTWVTASRAVADEVITSPAFDGLTADGRRPGARELPLSGT
                     ALDADRATCARFGALTAWGGPLLPAPHERALRESAERRAHTLLDGAEAALAADGTVDLV
                     DAYARRLPALVLREQLGVPEEAATAFEDALAGCRRTLDGALCPQLLPDAVAGVRAEAAL
                     TAVLASALRGTPAGRAPDAVAAARTLAVAAAEPAATLVGNAVQELLARPAQWAELVRDP
                     RLAAAAVTETLRVAPPVRLERRVAREDTDIAGQRLPAGGSVVILVAAVNRAPVSAGSDA
                     STTVPHAGGRPRTSAPSVPSAPFDLTRPVAAPGPFGLPGDLHFRLGGPLVGTVAEAALG
                     ALAARLPGLRAAGPAVRRRRSPVLHGHARLPVAVARTARDLPATAPRN"
     misc_feature    340..17245
                     /note="angolamycin biosynthesis gene cluster"
     CDS             1699..2973
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 378.4;
                     E-value: 8.5e-115)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf2; involved in the attachment of angalosamine"
                     /product="glycosyltransferase"
                     /protein_id="ABW91150.1"
                     /sec_met_domain="MGT (E-value: 1.7e-147, bitscore: 481.4,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILLTSFAHNTHYYNLVPLGWALRAAGHDVRVASQPSLTGTITG
                     SGLTAVPVGDDTAIVELITEIGDDLVLYQQGMDFVDTRDEPLSWEHALGQQTIMSAMCF
                     SPLNGDSTIDDMVALARSWKPDLVLWEPFTYAGPVAAHACGAAHARLLWGPDVVLNARR
                     QFTRLLAERPVEQREDPVGEWLTWTLERHGLAADADTIEELFAGQWTIDPSAGSLRLPV
                     DGEVVPMRFVPYNGASVVPAWLSEPPARPRVCVTLGVSTRETYGTDGVPFHELLAGLAD
                     VDAEIVATLDAGQLPDAAGLPGNVRVVDFVPLDALLPSCAAIVHHGGAGTCFTATVHGV
                     PQIVVASLWDAPLKAHQLAEAGAGIALDPGELGVDTLRGAVVRVLESREMAVAARRLAD
                     EMLAAPTPAALVPRLERLTAAHRRA"
     CDS             2992..3714
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248:methyltransferase (Score: 212.2; E-value:
                     1.4e-64)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf3"
                     /product="N-methyltransferase"
                     /protein_id="ABW91151.1"
                     /transl_table=11
                     /translation="MNLEYSGDIARLYDLVHQGKGKDYRAEAEELAALVTQRRPGARSL
                     LDVACGTGMHLRHLGDLFEEVAGVEMSPDMLAIAQRRNPEAGIHRGDMRDFALGRRFDA
                     VICMFSSIGHMRDQRELDAAIGRFAAHLPSGGVVIVDPWWFPETFTPGYVGASLVEAEG
                     RTIARFSHSALEDGATRIDVDYLVGVPGEGVRHLKETHRITLFGRAQYEAAFTAAGMSV
                     EYLPHAATDRGLFVGVQA"
     CDS             3789..5153
                     /NRPS_PKS="Domain: PKS_ER (59-420). E-value: 2.4e-24.
                     Score: 77.9. Matches aSDomain:
                     nrpspksdomains_ABW91152.1_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 326.4; E-value: 3.1e-99)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf4; provision of ethylmalonyl extender units"
                     /product="crotonyl CoA reductase"
                     /protein_id="ABW91152.1"
                     /sec_met_domain="ADH_N (E-value: 3.7e-09, bitscore: 26.3,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.7e-34, bitscore:
                     108.5, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRHIVEAIRSLTGPEGSASAVPADFAALELPEYFRAVTLRKDETE
                     MFAGMASADKDPRKSLHVQEVPIPELGPGEALVAVMASSVNYNTVWSSIFEPVSTFRFL
                     ERYGRLSPLTKRHDLPYHIIGSDLAGVVLRTGPGVNAWQPGDEVVAHCLSVELESPDGH
                     DDTMLDPEQRIWGFETNFGGLAEIALVKTNQLMPKPKHLTWEEAAAPGLVNSTAYRQLV
                     SRNGAAMKQGDNVLIWGASGGLGSYATQFALAGGANPICVVSSPQKAEICRKMGATAII
                     DRTAEGYRFWKDEHTQDPKEWKRFGKRIRELTGGEDIDIVFEHPGRETFGASVYVTRKG
                     GTITTCASTSGYMHEYDNRYLWMSLKRIIGSHFANYREAYEANRLIAKGKIHPTLSKTY
                     SLEDTGQAAYDVHRNLHQGKVGVLCLAPEEGLGVRDPELRDQHIDAINRFRRTRP"
     aSDomain        3966..5048
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ABW91152.1_PKS_ER.1"
                     /evalue="2.40E-24"
                     /label="ABW91152.1_PKS_ER.1"
                     /locus_tag="ABW91152.1"
                     /protein_end="420"
                     /protein_start="59"
                     /score="77.9"
                     /tool="antismash"
                     /translation="SLHVQEVPIPELGPGEALVAVMASSVNYNTVWSSIFEPVSTFRFL
                     ERYGRLSPLTKRHDLPYHIIGSDLAGVVLRTGPGVNAWQPGDEVVAHCLSVELESPDGH
                     DDTMLDPEQRIWGFETNFGGLAEIALVKTNQLMPKPKHLTWEEAAAPGLVNSTAYRQLV
                     SRNGAAMKQGDNVLIWGASGGLGSYATQFALAGGANPICVVSSPQKAEICRKMGATAII
                     DRTAEGYRFWKDEHTQDPKEWKRFGKRIRELTGGEDIDIVFEHPGRETFGASVYVTRKG
                     GTITTCASTSGYMHEYDNRYLWMSLKRIIGSHFANYREAYEANRLIAKGKIHPTLSKTY
                     SLEDTGQAAYDVHRNLHQGKV"
     CDS_motif       4482..4544
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ABW91152.1_0001"
                     /evalue="1.80E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="ABW91152.1"
                     /protein_end="252"
                     /protein_start="231"
                     /score="11.1"
                     /tool="antismash"
                     /translation="GDNVLIWGASGGLGSYATQFA"
     CDS             5377..7302
                     /codon_start=1
                     /note="Orf5"
                     /product="putative regulatory protein"
                     /protein_id="ABW91153.1"
                     /transl_table=11
                     /translation="MGDETLKGTAGTLRFLELLTADAPAWRYEELVQRAGAEGADPETI
                     EYLGRAKRLALQIEDRVSRGRRREAELTGLIDVVRELTRSPHPGAALDQIVRRTRMLMH
                     SDLACIALLEEPGGDAVISAVDGAVTTRLPGLRVPVTRGLGGAVARHQGPFWAVDYLTE
                     ERIAHDPVVDHTVQAEGLRAMLSVPLRSDSEQLGVLYVADRSAHDFLPDDVALLQSLAD
                     IAAVAVASDRLLARLEGQDGGPRAGAGPAEPGPPGPARIQQRLLELALDGAELDEVLDH
                     CARELGGALAVYDRHGDTVGRLRNIRRPHEAELERAYLDLHASGAPVELADGTWMATLT
                     ARSDPGWLLHRPDGTGDPGPPELLFAVANVVSMVLELRRSAPADHQWRDDLLEDLISIH
                     HPAEVAVARARRLQVRLDRPHIVVIARPDGPVAEHATAWATSWVRRRRGLKMTREDFVV
                     LLLPGDDPAAMAHEVSARLSAALEVPVTVGAAGPADGPESIQRFYQEAMRCVEALIAMG
                     GEGRAACARDLGFLGLLFAEDYDVTEFVNKIIGPVIEYDTQRFTVLVETLEAYFQAACS
                     PTRAAELLYVHPNTVSRRLERITQLLGRGWQEPDHALELQLALRLHRTRCASQAPDTDD
                     CASRDR"
     misc_feature    5392..5394
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(7306..8550)
                     /codon_start=1
                     /note="Orf6; similar to Streptomyces fradiae TylR"
                     /product="putative regulatory protein"
                     /protein_id="ABW91154.1"
                     /transl_table=11
                     /translation="MGTLTTAPTTPHHPAHSPEAHLTEEVCASVLASLRRRDQRHKGRL
                     YVNGLLTARGRKTMRNLATSTREPAAAQSLHHFISVSTWDWSEVRASLARRMERLMTPH
                     AWVVQPMVTPKSGVHSVGVQRRFIRHLGQAVTSQHSHGLWLAGQSAAAPVNWQLSVGED
                     RPGAPAPGVRDGVPETVGGGWSGDDTAISVVLQAASWGLTPRPVVIDARDVPPAPLIEA
                     FTAADLPFLLRVGGNTPLLAPDLSSGQRRVLSASAEHLTTLARSQQRPVEWVDPAVPRV
                     LRTGLVALLPVLWPGVTVPRRPRPAGVRVVAPRRSGGAELLLMGEWQPNRRRVAELWLT
                     NMTGAGRGTLLRLSKLTRRADTDFARICMDVGAQDFEGRSYHGWHRHMTMVSLAHAVRV
                     LTREHHAGEELERSG"
     CDS             8992..9975
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     175.3; E-value: 3.3e-53)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf7"
                     /product="NDP-hexose 4-ketoreductase"
                     /protein_id="ABW91155.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 8.6e-11, bitscore:
                     31.2, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLNQSRNTSGPLIVVLGASGFLGPAVIDRLAGLPVRVRAVARGVS
                     PVPPRAVAEIEGYRTDLARPGAVARAVEGADAVVHLAAHVGGDRSWRAAGEDSERVNIG
                     LMRDLVTVFEGRDAPAPAVVFASTAQAGGAADHARAAYARQKIAAEELLREATARGTVR
                     GVALRLSTVYGRAPLTGSSGRGVLAAMARRALDGAPLTMWHDGTVERDFLHVRDAARAF
                     VTALDHLPRLQGGDWSVGSGSRVRLGDVFRSLADTVAERTGRPPVPVLSVEPPDFAEAG
                     DFRTPDCDPAAFGAVTGWSPSVPLHEGLDELVAALVAAEASTSREP"
     CDS             10030..11034
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     318; E-value: 9.7e-97)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf8"
                     /product="4-keto-6-deoxy NDP-hexose 2,3-reductase"
                     /protein_id="ABW91156.1"
                     /transl_table=11
                     /translation="MSEDRKRTPYVRLGRSATLVSRLWLGTVNFSGRVEDADASRLLSA
                     ALDRGINCVDMANIYGWRVHKGHTEELVGRWLSKSGVRREDVLLATKVGEDMSDRVNDG
                     GLSARHIVAACEQSLRRLDVDHIDLYQMHRLDSAAPWDEIWQAMDRLVTSGKVCYVGSS
                     NFAGWNIAAAQETAMRRNTMGLVSEQSIYNLAMRRADAELIPAARAYGVGVFAWSPLHG
                     GLLSGALRKLAEGTAVKSAQGRAQELLPDLRANIEAYERFCERIGEHPAEVGLSWVLSR
                     PGISGAVIGPRTLGQLDSALRALDLHLGDEELAELDALFPVPGDAARPPMTAR"
     CDS             complement(11079..12311)
                     /codon_start=1
                     /note="Orf9"
                     /product="NDP-hexose 3-C-methyltransferase"
                     /protein_id="ABW91157.1"
                     /transl_table=11
                     /translation="MIITACRICGNRELLPVLDLGEQALTGVFPTRRDQEVPSVPLELV
                     VCSPAGCGLVQLRPTPDADLMYGDDYGYRSGIRPFMIHHLHDKVAAILDLVELGPRDLV
                     VDIGSNDATLLRGYPEDGPRLVGIDPTGGKFRDRYPANAELVVDYFSRKTFEDRFGRQR
                     AKVVTSIAMFYDLPDPMRFMQDVHDILADDGIWVMEQSYMPSMLGADAYDVVCHEHLEY
                     YALRQIEWMAERVGLTVIRAELTEVYGGSLCVTLARSPGRYARDEAGLARIRAREAEAG
                     LDTTAPFEAFARRVERQREALLEFLARSREAGKVTFGYGASTKGNVILQYCGLTERDLP
                     CIGEVSPEKAGRFTPGTRIPIVSEEDAKAGKPDQLLVLPWIYRDGFVEREQRFVAGGGK
                     LVFPLPELSVV"
     CDS             12530..13744
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 300.5;
                     E-value: 3.7e-91)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf10; involved in the attachment of mycarose"
                     /product="glycosyltransferase"
                     /protein_id="ABW91158.1"
                     /sec_met_domain="MGT (E-value: 2.8e-57, bitscore: 184.4,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHIAFFILPVPGHVNPTLGVAEELVARGHRVTYALPEDIAGRAR
                     RVGAEAVTYPMDRERFRTHMVPQQNSDEYTDKGEILRVLEWLLEMTDRTVEPLERHFRD
                     DRPDVIVHDPSSFWTGRILADRWGVPAIRSTPTYAANEHWSMHPGAEAAGPPDDPALLE
                     LVGGIDRLLRAQGVDDDAGTFTGRVHSGPALLYMPRTFQYAGETFDDQHHFVGPCAPRA
                     SFHGTWEPPHDGRPLVMVSMGTLYNQRPDFFRACVEAFRDEPWNVLLVLGGGLAPEDLG
                     PLPDNVRVRDFVPLADVFPHTALVVNHGGMSTAMEAFSHGVPVVAVPVMTEPRATARRI
                     AELGLGAQLPGPGVSAADLRATARRVLADDGIRERLRWMRERIRAAGGAAAAATVIERL
                     LPAQP"
     CDS             13797..14405
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf11"
                     /product="NDP-hexose 3,5-epimerase"
                     /protein_id="ABW91159.1"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 2.8e-44,
                     bitscore: 140.5, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLITETAVPDAYRIQPELLPDHRGRFYEGLRYETLRAATGHAFEL
                     RQVNFTVSHRNVLRGVHGTTMPPGQGKIVTCVRGAARAMVVDLRVGSPAFGHHDVLRLD
                     PRDATALYVPDGLGLAYVALTDDTCVNYLCDREYVHGTIIDVDALDPALALPWDLDEPP
                     VRSARDAAAPTLAEALAGGTLPTYEQCRRGYRTLPVAGR"
     CDS             14402..15505
                     /codon_start=1
                     /note="Orf12"
                     /product="transaldolase"
                     /protein_id="ABW91160.1"
                     /transl_table=11
                     /translation="MTAWARDRPHRSRHGVRLAAEGVCLRMEDLTRELHGAGRLARLLG
                     ELGACATAARPAAVREAVRRGDAYRDRLSDLACRRVPTAEAVLSLLWEDARAACDTLLP
                     HYRRGAGLCACVFVPLNPYADGRRAVAEAAALRWTVDRPNTVVSVHLARGGVPLVGDLL
                     ARGISVDVRSLFTLQQFDLLFEEFLGGLERARDAGCDLSGIHFAASVPLRVLDETIAAR
                     LGATACREEWAVAVARLLHHRREQLMDGARWQALVRAGARPPHFVWSAREAPVREAVRY
                     LEELVGWNSVFSAGPVTLRAVRARAELRGDTISGTEAHSRHVLSALRCREVDLGAMGLE
                     LQQAQLEAARGEWTELCGAVGATLGHV"
     CDS             complement(15512..17245)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 108.6; E-value:
                     6.8e-33)"
                     /gene_kind="transport"
                     /note="Orf13"
                     /product="exporter/resistance protein"
                     /protein_id="ABW91161.1"
                     /transl_table=11
                     /translation="MRVAQFALHDITKRFAGHVVLDRVDFTVRPGERIGIVGDNGSGKS
                     TLLRLIAGRDTPDNGAVTVVAPGGVGYLPQSLELPENAVVQDAVDLALADLRDLEDGLR
                     RSEAELGERPFQSGQDPELAGLVESFAALVDRYQARGGYEADSRVDIALHHLGLPGLER
                     DRPLATLSGGERSRLALAGTLASAPELLLLDEPTNDLDEHAVIWLEEHLRRHRGTVVAV
                     THDRVFLERLTTTVLEVDSGRVTRYGNGYEGYLSAKPAERRRRLREYEQWRAELDSNRE
                     LVSTHVSRMDGIPRKLPFAVFGAGLYRMRGRGHGAMVRIRNAKERVARLTENAVARPAD
                     PLAFTAVLSTTTDRPAAETAPEAVTETAAETVAELADVRVDGRLRVGSLRIGRGERLLV
                     TGPNGAGKTTLLRVLAGELAADGGSVTVTGRVGHLRQDPTPWPSAMTVPQAFAQGRGGH
                     PDEHVEELLSLGLFGPDDLRRRVGELSYGQRRRIELARLVSDPVDLLLLDEPTNHLSPA
                     LVEELEQALTGYRGAVVVVTHDRRMRQRFAGSRLRLDAGRVAAFATRYPGPAGGGPARV
                     R"
ORIGIN
        1 ggccgaacgc tccgccgtcc ccctggacga cacccgcctg accgccatgg gggcctacca
       61 ccggatactg ctcgactggc agccgcggcc cacccgcgca cccgtcctcc acctccgggc
      121 cgccgagccc ctcggagagt ggaccggggc gccggacggc tggcagtcgc gctgggagta
      181 cgcccacacc accgcggcgc tgcccggaac gcacttcacg ctgatgggcg agcacgcgcc
      241 cgccaccgca cgggccgtcc tcgactggct cgacggcctg cgcccgaccg gcccggacgg
      301 ccgcccggcg accggaacca cccacgacga gagggaccag tgagccccgc acccgccacc
      361 gaggacccgg ccgccgccgg gcgccgcctg caactgaccc gcgcagccca gtggttcgcg
      421 ggaacccagg acgacccgta cgcgctcgtc ctgcgcgccg aggccaccga cccggccccg
      481 tacgaggagc ggatccgggc ccacgggccg ctcttccgca gcgacctgct cgacacctgg
      541 gtcacggcga gcagggccgt cgccgacgaa gtgatcacct cacccgcctt cgacgggctc
      601 acggccgacg ggcggcgccc cggcgcgcgg gaactgccgc tgtccggcac cgcgctcgac
      661 gcggaccgcg ccacatgcgc acggttcggg gccctcaccg cctggggcgg gccgctgctg
      721 ccggcgccgc acgagcgggc gctgcgcgag tccgccgaac ggcgggccca cacactcctc
      781 gacggggcgg aggccgccct ggccgccgac ggcaccgtcg acctcgtcga cgcgtacgcc
      841 cgcaggctcc ccgcgctggt cctccgcgaa cagctcggcg tgccggagga ggcggcgacc
      901 gccttcgagg acgcgctggc cggctgccgc cgcaccctgg acggcgccct gtgcccgcaa
      961 ctcctcccgg acgccgtggc gggggtgcgc gcggaagccg cgctgaccgc cgtgctggcc
     1021 tccgccctgc gcgggactcc ggccggccgg gcccccgacg ccgtcgccgc cgcccgcacc
     1081 ctggccgtcg cggccgccga gcccgcagcc accctcgtcg gcaacgccgt acaggagctg
     1141 ctggcgcgtc ccgcgcagtg ggcggagctc gtacgcgacc cgcgcctcgc ggccgccgcg
     1201 gtgaccgaaa cgctgcgtgt cgccccgccc gtccgcctgg agcggcgggt cgcccgcgag
     1261 gacacggaca tcgccgggca gcgcctcccc gccgggggga gcgtcgtgat cctcgtcgcc
     1321 gccgtcaacc gcgcgcccgt atccgcggga agcgacgcct ccaccaccgt cccgcacgcc
     1381 ggcggccggc cccgtacctc cgccccctcc gtcccctcag cccccttcga cctcacacgg
     1441 cccgtggccg cgcccgggcc gttcgggctc cccggcgacc tgcacttccg cctcggcggg
     1501 cccctggtcg gaacggtcgc cgaagccgcg ctcggtgcgc tggccgcacg gctccccggt
     1561 ctgcgcgccg ccgggccggc cgtgcggcgc cgccgctcac cggtgctgca cggacacgcc
     1621 cgcctccccg tcgccgtcgc ccggacggcc cgtgacctgc ccgccaccgc accgcggaac
     1681 tgaggaggga gtgccccgat gcgtatcctg ctgacgtcgt tcgcgcacaa cacgcactac
     1741 tacaacctgg tccccctcgg ctgggcgctg cgcgccgccg ggcacgacgt acgggtcgcc
     1801 agccagccct cgctgaccgg caccatcacc ggctccgggc tgaccgccgt ccccgtgggc
     1861 gacgacacgg ccatcgtcga gctgatcacc gagatcggcg acgacctcgt cctctaccag
     1921 cagggcatgg acttcgtgga cacccgcgac gagccgctgt cctgggaaca cgccctcgga
     1981 cagcagacga tcatgtcggc catgtgcttc tcgccgctga acggcgacag caccatcgac
     2041 gacatggtgg cgctggcccg ttcctggaaa ccggacctcg tcctgtggga gcccttcacc
     2101 tacgcgggac ccgtcgccgc gcacgcctgc ggcgccgccc acgcccggct gctgtggggt
     2161 cccgacgtgg tcctcaacgc acggcggcag ttcacccggc tgctcgccga gcgccccgtc
     2221 gaacagcgcg aggacccggt cggcgaatgg ctcacgtgga cgctggagcg ccacggcctc
     2281 gccgccgacg cggacacgat cgaggaactg ttcgccgggc agtggacgat cgaccccagc
     2341 gccgggagcc tgcggctgcc ggtcgacggc gaggtcgtgc ccatgcgctt cgtgccgtac
     2401 aacggcgcct cggtcgtccc cgcctggctc tccgagccgc ctgcccggcc ccgggtctgc
     2461 gtcaccctcg gcgtctccac ccgggagacc tacggcacgg acggcgtccc gttccacgaa
     2521 ctgctggccg gactggccga cgtggacgcc gagatcgtcg ccaccctcga cgcggggcag
     2581 ctcccggacg ccgccggtct gcccggcaat gtgcgcgtcg tcgacttcgt gccgctggac
     2641 gccctgctgc cgagctgcgc cgcgatcgtc caccacggag gcgcgggaac ctgtttcacg
     2701 gccaccgtgc acggcgtccc gcagatcgtc gtggcctccc tctgggacgc gccgctgaag
     2761 gcgcaccaac tcgccgaggc gggcgccggg atcgccctgg accccgggga actgggcgtg
     2821 gacaccctgc gcggcgccgt cgtgcgggtg ctggagagcc gcgagatggc cgtggcggcg
     2881 cgtcgcctcg ccgacgagat gctcgccgcc cccaccccgg ccgcgctcgt cccccgcctc
     2941 gaacgcctca ccgccgcgca ccgccgcgcc tgatcccgcc aaggagcccc catgaacctc
     3001 gaatacagcg gcgacatcgc ccggttgtac gacctggtcc accagggaaa gggcaaggac
     3061 taccgggcgg aggccgagga gctggccgcg cttgtcaccc agcgccgccc cggggcccgc
     3121 tccctcctcg acgtggcctg cggaacgggg atgcacctgc ggcacctcgg cgacctcttc
     3181 gaggaggtgg ccggggtgga gatgtccccc gacatgctgg ccatcgcgca gcggcgcaac
     3241 ccggaggccg gcatccaccg gggggacatg cgggacttcg ccctcggccg ccgcttcgac
     3301 gccgtgatct gcatgttcag ttccatcggg cacatgcgcg accagcggga actggacgcg
     3361 gcgatcggcc ggttcgccgc gcacctgccg tccggcgggg tcgtgatcgt cgatccctgg
     3421 tggttcccgg agacgttcac accggggtac gtcggcgcga gcctcgtcga ggccgagggc
     3481 cgcaccatcg cgcgcttctc ccactccgcg ctcgaggacg gcgcgacccg gatcgatgtg
     3541 gactacctcg tcggcgtgcc gggggagggg gtgcggcact tgaaggagac ccatcggatc
     3601 acgcttttcg ggcgtgcgca gtacgaggcg gccttcaccg cggcggggat gtccgtcgag
     3661 tacctcccgc acgccgccac cgaccgcgga ctcttcgtcg gcgtccaggc ctgaggaggc
     3721 gaccaaggat ggggcacggc atggcacagg acacggcaca cggcaacgca ccgggcggag
     3781 gacaagggat gcggcacatc gtcgaggcga tccggtcgct caccgggccg gagggctcgg
     3841 cgtcggccgt ccccgcggac ttcgcggccc tcgaactgcc cgagtacttc cgggcggtga
     3901 ccctccgcaa ggacgagacc gagatgttcg ccgggatggc gagcgccgac aaggacccgc
     3961 gcaagtcgct gcacgtccag gaggtgccca taccggaact cggccccggc gaggcgctgg
     4021 tggccgtgat ggccagctcc gtgaactaca acacggtgtg gtcctcgatc ttcgagccgg
     4081 tgtcgacgtt caggttcctg gagcggtacg ggcggttgtc accgttgacc aagcgccatg
     4141 acctgccgta ccacatcatc ggttccgacc tcgcgggtgt ggtgctgcgc accggccccg
     4201 gcgtgaacgc ctggcagccc ggtgacgagg tcgtcgcgca ctgcctgagc gtggagctgg
     4261 agtcgcccga cggccatgac gacacgatgc tcgaccccga gcagcgcatc tggggattcg
     4321 agaccaactt cggcggcctc gcggagatcg cgctggtcaa gacgaaccag ctgatgccga
     4381 agccgaagca cctcacctgg gaggaggccg cggccccggg cctggtgaac tccaccgcct
     4441 accgccagct ggtctcccgc aacggcgccg cgatgaagca gggcgacaac gtcctgatct
     4501 ggggcgcgag cggcggactc ggcagttacg ccacccagtt cgccctcgcc ggcggcgcca
     4561 accccatctg cgtcgtctcc tcgccccaga aggcggagat ctgccggaag atgggcgcca
     4621 cggcgatcat cgaccgcacc gccgagggct acaggttctg gaaggacgag cacacccagg
     4681 atcccaagga gtggaagcgc ttcggcaagc gcatccgcga actcaccggc ggcgaggaca
     4741 tcgacatcgt cttcgagcac cccggccgcg agaccttcgg cgcctccgtc tacgtcaccc
     4801 gcaagggcgg caccatcacc acctgcgcct cgacctcggg ctacatgcac gagtacgaca
     4861 accgctacct gtggatgtcc ctgaagcgga tcatcggctc gcacttcgcc aactaccgcg
     4921 aggcctacga ggccaaccgc ctcatcgcca agggcaagat ccacccgacg ctgtcgaaga
     4981 cgtactccct ggaggacacc gggcaggccg cctacgacgt ccaccgcaac ctgcaccagg
     5041 gcaaggtcgg cgtcctctgc ctcgcccccg aggaaggtct cggcgtgcgc gatccggagc
     5101 tgcgcgacca gcacatcgac gccatcaacc gcttccggcg gacgcgccct tgacgatctc
     5161 caagggtgat cgtttaatca cttcaggcca gtaggtaaaa atttcttact gttgttgtcg
     5221 ctccggggac cgaacccgat caccggtggg gcagggagcg caggacgggc atgaccccga
     5281 ccagtctgcc ggcaccggcg ctcccgcgca cgtaaggcga cggcgccggg atcgccgaat
     5341 cccggcgcgg gtcaccagca acaaccgggg gcgttgatgg gagacgagac tttaaaggga
     5401 acggccggga cgctgcgctt cctggaactc ctcaccgccg acgctccggc ctggcggtac
     5461 gaggaactgg tgcagcgggc cggcgccgag ggcgccgacc ccgagaccat cgagtacctc
     5521 ggccgggcca agcgcctcgc gctccagatc gaggaccgcg tcagccgcgg ccggcggcgc
     5581 gaggcggagc tcaccggcct catcgacgtg gtgcgcgagc tgacccggtc cccgcacccg
     5641 ggagcggcgc tcgaccagat cgtccggcgc acccggatgc tgatgcacag cgacctcgcc
     5701 tgcatcgccc tcctcgagga gccgggcggc gacgccgtga tcagcgccgt cgacggcgcc
     5761 gtcaccaccc gcctgcccgg cctgcgggtg cccgtcacgc ggggactcgg cggggccgtc
     5821 gcccggcacc agggcccgtt ctgggcggtc gactacctca ccgaggaacg catcgcccac
     5881 gatccggtcg tcgaccacac cgtgcaggcg gaagggctgc gcgccatgct gtccgtcccc
     5941 ctgcggtcgg acagcgagca actgggcgtc ctctacgtgg cggaccgcag cgcgcacgac
     6001 ttcctgccgg acgacgtggc gctgcttcag tcgctcgccg acatcgccgc cgtcgccgtc
     6061 gcctcggacc ggctcctcgc ccggctggaa gggcaggacg gcggcccgcg ggcgggtgcc
     6121 ggccccgccg agcccggccc gccggggccg gcccgcatcc agcagcgcct gctggaactg
     6181 gcgctcgacg gcgccgagct ggacgaggtg ctggaccact gtgcccgtga gctcggcgga
     6241 gcactggcgg tctacgaccg gcacggcgac accgtcgggc gcctccggaa catacgccgg
     6301 ccgcacgagg ccgagctgga acgggcgtac ctcgacctcc acgcctccgg ggcgcccgtc
     6361 gagctggccg acggcacctg gatggcgacg ctgaccgcac gctccgaccc cggctggctc
     6421 ctgcaccgcc cggacgggac gggggacccc ggcccgccgg agctgctgtt cgccgtggcc
     6481 aacgtcgtca gcatggtgct ggaactgcgg cgctccgccc ccgccgacca ccagtggcgg
     6541 gacgacctgc tggaagacct gatcagcatc caccaccccg ccgaggtggc ggtggcccgg
     6601 gcccgccggc tccaggtgcg gctggaccgt ccgcacatcg tggtcatcgc ccgcccggac
     6661 ggcccggtcg ccgaacacgc caccgcctgg gccacctcct gggtgcggcg ccgccggggc
     6721 ctgaagatga cccgggagga cttcgtggtg ctgctgctgc ccggggacga cccggcggcc
     6781 atggcgcacg aggtgtcggc ccggctcagc gcggcgctcg aggtgccggt gacggtcggg
     6841 gccgccggtc ccgccgacgg ccccgagtcc atccagcgct tctaccagga ggcgatgcgc
     6901 tgcgtggagg ccctcatcgc catgggcggc gaggggcggg cggcctgcgc gcgggacctc
     6961 ggcttcctcg gcctgctgtt cgccgaggac tacgacgtca ccgaattcgt caacaagatc
     7021 atcggcccgg tcatcgagta cgacacccag cggttcaccg tgctcgtcga gacgctggag
     7081 gcgtacttcc aggcggcgtg cagcccgacc cgcgcggccg agctgctgta cgtccacccc
     7141 aacaccgtct cccggcgtct ggaacgcatc acccagctgc tgggccgcgg ctggcaggag
     7201 ccggaccacg ccctggaact gcagctcgcg ctgcggctgc accgcacgcg ctgcgcgtca
     7261 caggcgccgg acacggacga ctgcgcttcc cgggaccgct gacgctcacc cggaccgctc
     7321 gagctcctcg cccgcgtggt gctcccgcgt cagcacccgg accgcgtgcg ccagggagac
     7381 catcgtcatg tgacggtgcc acccgtggta cgaacgccct tcgaagtcct gggcgccgac
     7441 gtccatgcag atgcgggcga agtcggtgtc ggcccgccgg gtgagcttgc tcagccgcag
     7501 cagggtgccg cggcccgcgc cggtcatgtt ggtgagccac agctcggcta cgcgccgtct
     7561 gttcggctgc cactcgccca tcagcagcag ctccgccccg ccggaccgcc gcggggcgac
     7621 cacccggaca ccggccgggc gcggccggcg cggcacggtg acccccggcc acagcaccgg
     7681 aagcagcgcc accagaccgg tgcgcagcac ccgcggcacg gccgggtcca cccactccac
     7741 gggccgctgc tgcgacctgg cgagcgtggt gaggtgctcc gcggacgccg acagcacccg
     7801 gcgctgcccg ctcgacaggt ccggtgccag caggggggtg ttgcccccca cgcgcagcag
     7861 gaacggcagg tcggcggcgg tgaacgcctc gatgagcggt gccggcggca catcccgcgc
     7921 gtcgatcacc acgggtctcg gcgtgagtcc ccaggaagcc gcctgcagga ccaccgagat
     7981 cgccgtgtcg tcaccggacc agccgccgcc cacggtctcg ggcacaccgt cgcgcacacc
     8041 gggcgcgggg gcgccgggcc ggtcctcgcc cacggacagc tgccagttga ccggcgccgc
     8101 cgcgctctgg ccggcgagcc acagcccgtg gctgtgctga ctggtgacgg cctggcccag
     8161 gtggcggatg aagcgccgct ggacccccac cgagtgcaca ccgctcttcg gcgtcaccat
     8221 gggctgcacc acccaggcgt gcggcgtcat cagccgttcc atccggcggg cgagcgaggc
     8281 gcgtacctcg gaccagtccc acgtcgagac gctgatgaag tggtgaaggc tctgggcggc
     8341 ggcgggttcg cgcgtgctgg tggcgaggtt ccgcatcgtc ttgcggcccc gcgcggtgag
     8401 cagtccgttc acgtacagcc gtcctttgtg ccgctggtcg cggcggcgca gtgaggccag
     8461 caccgaggca cacacctctt cggtgaggtg cgcttcaggg gagtgggccg gatggtgggg
     8521 ggtcgtcggg gcagtcgtca gcgtccccat gaagctcctc agagtcggga ttcgcagtgc
     8581 ttgccggtcg ggctcgtcgg gtcctcagcc ttgtccgccg caaccggagg ccacaggtcc
     8641 gcaggcgacc cacttgtccc ggggccgcgg tggccggttc acagcggtgg ccgcggacgc
     8701 ccccatacag tcggccgggg ggtggccgga ccaccgcggt cacccccgcg caggccgtcc
     8761 ggggcggtcc gggcggtggt cccggaaccg tggtgccgtg gcgcgcggtg cgtccggggc
     8821 cctcgggacc gcccgcggcg gggaggggtg tgccgacatg acacagcttc atcaaatcgt
     8881 ccccgcgcac gacgaattgg cacgtcaacc ctcgtacggg cgatcacccc tctgataggt
     8941 tcggcgcacg gggatgggcg gatgaggaga catgtgaagc tcgctgccga ggtgctgaac
     9001 cagtcgcgga acaccagcgg accactgatc gtcgtactcg gcgcgtccgg gttcctcggg
     9061 cccgccgtca tcgaccggct cgccggcctg ccggtgcggg tccgcgcggt ggcccggggc
     9121 gtaagtcccg tacccccgcg ggccgtggcc gagatcgagg ggtaccggac ggacctcgcc
     9181 cggcccggcg cggtcgcccg cgccgtcgag ggagccgacg ccgtcgtcca cctcgccgcc
     9241 cacgtcggcg gcgaccgctc ctggcgcgcc gccggtgagg actcggagcg ggtgaacatc
     9301 ggcctgatgc gcgacctggt cacggtgttc gaaggacgtg acgcccccgc gcccgcggtg
     9361 gtgttcgcga gcaccgcgca ggccggcgga gccgcggacc acgcccgcgc cgcctacgca
     9421 cggcagaaga tcgccgccga ggaactgctg cgggaggcca ccgcacgggg caccgtccgg
     9481 ggtgtcgcgc tgcggctgtc gaccgtctac ggccgcgccc cgctgaccgg ttcgtccggg
     9541 cgcggcgtgc tcgccgcgat ggcccggcgc gccctcgacg gcgctccgct caccatgtgg
     9601 cacgacggaa ccgtcgaacg cgacttcctc cacgtgcgcg acgccgcccg cgccttcgtc
     9661 accgcgctgg accacctgcc gcgcctccag ggcggcgact ggtccgtcgg cagcggcagc
     9721 cgcgtccgcc tcggcgacgt gttccgctcc ctcgcggaca ccgtggccga acggaccgga
     9781 cgcccgcccg tcccggtcct ctccgtggaa ccgcccgact tcgccgaagc gggcgacttc
     9841 cgcactccgg actgcgaccc cgcggcgttc ggcgccgtga cggggtggtc cccctccgta
     9901 cccctgcacg aggggctgga cgaactggtg gccgcactgg tcgccgcgga ggcgagcaca
     9961 tcgcgcgagc cgtgaccgga caccggctca gcgagccccc atggccgagt tgaagggaag
    10021 aatccgagcg tgagcgagga ccggaagcgg acaccgtacg tacggctcgg acgcagcgcg
    10081 actctggtga gccggctctg gctgggcacg gtgaacttca gcggacgggt ggaggacgcc
    10141 gatgcctcgc ggctgctgag cgccgcgctc gaccgcggca tcaactgcgt cgacatggcg
    10201 aacatctacg gatggcgcgt ccacaaggga cacaccgagg aactcgtcgg ccgctggctg
    10261 tcgaagagcg gtgtccggcg ggaggacgtc ctgctggcca ccaaggtcgg cgaggacatg
    10321 agcgaccggg tcaacgacgg aggactgtcg gcccggcaca tcgtcgccgc ctgcgagcag
    10381 tcgctgcgcc gcctcgacgt cgaccacatc gacctctacc agatgcaccg cctggacagc
    10441 gcagcaccct gggacgagat ctggcaggcc atggaccgcc tcgtgaccag cgggaaggtc
    10501 tgctacgtcg gctcgtcgaa cttcgccggc tggaacatcg ccgccgcgca ggagaccgcc
    10561 atgcgccgca acaccatggg gctggtctcc gagcagagca tctacaacct ggcgatgcgc
    10621 cgggccgacg cggagctgat ccccgccgcc cgggcgtacg gggtcggggt gttcgcctgg
    10681 tcaccgctgc acggcggact gctgagcggg gcactgcgca agctggcgga gggcaccgcc
    10741 gtgaagtcgg cccagggccg cgcgcaggaa ctcctgccgg acctgcgggc caacatcgag
    10801 gcgtacgagc ggttctgcga gcgcatcggg gagcacccgg cggaggtcgg cctgtcctgg
    10861 gtgctgtccc ggccgggcat cagcggcgcg gtgatcgggc cacgcaccct cggacagctc
    10921 gactcggcgc tgcgcgccct cgacctgcac ctgggcgatg aggaactggc cgaactcgac
    10981 gccctgttcc ccgtaccggg cgacgccgca cggcctccga tgacggcgcg gtgagccgcg
    11041 gggggcggcc gatgccgccg gccggacggc gaccctgctc agacgacgct gagctccggc
    11101 aacgggaaga ccagcttgcc gccgccggcc acgaaccgct gctcccgctc gacgaagccg
    11161 tcccggtaga tccacggcag taccagcaac tggtccggct ttcccgcctt ggcgtcctcc
    11221 tcggacacga tcgggatccg tgtgccgggc gtgaagcggc ccgccttctc cggggagacc
    11281 tcaccgatgc agggcaggtc ccgctccgtc agcccgcagt actggagaat cacgttcccc
    11341 ttggtcgagg cgccgtaccc gaaggtcacc ttcccggcct cccgggaccg ggcgaggaac
    11401 tccagcaggg cctcccgctg ccgctcgacc cgccgggcga acgcctcgaa cggagcggtg
    11461 gtgtcgagcc cggcctccgc ctcccgcgcc cggatccgcg cgagccccgc ctcgtcgcgc
    11521 gcgtaccggc cggggctcct ggccagcgtg acgcacagac tgccgccgta gacctcggtc
    11581 agctccgccc tgatcacggt cagtccgacc cgctcggcca tccactcgat ctgccgcagg
    11641 gcgtagtact ccaggtgctc gtggcacacc acgtcgtacg cgtccgcgcc cagcatggac
    11701 ggcatgtagc tctgctccat gacccagatg ccgtcgtcgg cgaggatgtc gtggacgtcc
    11761 tgcatgaaac gcatcggatc cggcaggtcg tagaacatgg cgatggacgt gacgaccttc
    11821 gcccgctgcc ggccgaaacg gtcctcgaac gtcttccggg agaagtagtc cacgacgagt
    11881 tccgcgttcg ccggatacct gtcgcggaac ttaccgccgg tcgggtcgat accgaccagc
    11941 cggggcccgt cctcgggata gccgcgcagc agagtggcgt cattgctgcc gatgtccacg
    12001 accaggtccc gcggccccag ttccaccagg tcgagaatgg ccgccacctt gtcgtgcaga
    12061 tggtggatca tgaagggccg gataccggag cggtaaccgt aatcgtcgcc gtacatcaga
    12121 tcggcgtcgg gggtggggcg cagctgcacc agcccgcatc ccgcggggga gcagacgacc
    12181 agctccagcg gcaccgaggg gacctcctgg tcgcggcgcg tcgggaacac accggtcagc
    12241 gcctgttccc cgagatccag caccgggagc agctcgcgat tgccgcagat acggcacgca
    12301 gtgatgatca ttaccggatt ctcccgccgt ggtgacgggc gatcgacgaa tcgggcggca
    12361 ctttgtcaca tgacgccgac gaacgagcga accgcactat gtcagctcgg tattgccgtc
    12421 caccggacgg ctcttttact gtgtggcgcc gtactgcccg aaggcgcgtc tcattccgcc
    12481 cggcgcggct ccgttcgtgc gaccgaaaac acccagtgaa gggttccgcg tggctcatat
    12541 cgcattcttc atcctccccg tgcccgggca tgtgaatccg accctgggag tggccgagga
    12601 actcgtggcg cgcggtcacc gggtcaccta cgcactgccg gaggacatcg cggggcgcgc
    12661 gcggcgcgtc ggcgcggagg ccgtcaccta tcccatggac cgggagcggt tccgcaccca
    12721 catggtgccg cagcagaatt ccgacgagta caccgacaag ggcgagatac tccgcgtcct
    12781 tgaatggctg ctggagatga cggaccggac cgtggagccg ttggagcggc atttccggga
    12841 cgaccgcccc gatgtgatcg tgcacgatcc ctcgtcgttc tggacgggac gcatcctcgc
    12901 cgaccggtgg ggcgtcccgg ccatccgcag caccccgacg tacgcggcca acgagcactg
    12961 gtccatgcac cccggcgcgg aggcggccgg gccccccgac gatcccgccc tcctcgaact
    13021 cgtcggcggg atcgaccggc tgctgcgcgc gcagggcgtc gacgacgacg cgggcacctt
    13081 caccgggcgc gtccacagcg gcccggccct gctctacatg ccccgcacct tccagtacgc
    13141 cggggagacc ttcgacgacc agcaccactt cgtcgggccg tgcgcgcccc gcgcctcctt
    13201 ccacggcacc tgggagccgc cgcacgacgg caggccgctc gtcatggtga gcatgggcac
    13261 cctctacaac cagcggcccg atttcttccg cgcctgcgtc gaggcgttcc gcgacgagcc
    13321 ctggaacgtc ctgctggtgc tgggcggcgg cctggccccc gaggacctgg gcccgctgcc
    13381 ggacaacgtc cgcgtacggg acttcgtccc gctcgccgac gtcttcccgc acacggccct
    13441 ggtggtgaac cacggcggga tgagcacggc gatggaggcc ttctcgcacg gcgtccccgt
    13501 ggtggccgta ccggtgatga cggaaccgcg ggccaccgcg cgccggatcg ccgaactcgg
    13561 cctgggcgcc cagctgcccg gccccggggt gagcgcggcg gacctgcgcg ccaccgcgcg
    13621 tcgcgtgctc gccgacgacg ggatccgcga gcggctgcgg tggatgcgcg aacggatccg
    13681 ggcggccgga ggcgccgccg cggcggccac cgtcatcgaa cggctgctgc ccgcgcagcc
    13741 ctgaatccct ccgcccgcgc gtcagcgccc gtcctccgac cagtgggaaa ccgaccatgc
    13801 tcatcaccga aacggccgtg cccgacgcct accgcatcca gccggagctc ctcccggacc
    13861 accgcggccg gttctacgag ggcctgcggt acgagacgct gcgggcggcc accgggcacg
    13921 ccttcgagct ccggcaggtc aacttcacgg tgtcccaccg caatgtgctg cgcggcgtcc
    13981 acggcaccac gatgcccccc ggccaaggca agatcgtcac ctgtgtacgg ggcgccgccc
    14041 gcgccatggt cgtcgacctc agagtgggct caccggcctt cggccaccat gacgtcctgc
    14101 ggctggaccc ccgcgacgcc accgccctct acgtgcccga cggactgggc ctggcctacg
    14161 tcgccctcac cgacgacacc tgcgtgaact acctgtgcga ccgggagtac gtccacggca
    14221 ccatcatcga cgtcgacgcc ctcgaccccg ccctggccct tccgtgggac ctggacgaac
    14281 ccccggtgcg gtcggcccgg gacgccgccg cccccaccct cgccgaggcc ctcgccggcg
    14341 ggaccctgcc cacctatgag caatgccgtc gcggttaccg gaccctcccc gtcgccggcc
    14401 ggtgaccgcg tgggcccggg acaggcctca ccggagccgg cacggcgtca gactcgcggc
    14461 cgaaggcgtc tgcctgcgca tggaggacct gacccgcgag ctgcacggcg ccggccgtct
    14521 ggcgcggctg ctcggcgaac tcggcgcgtg cgccaccgca gcccggcccg ccgcggtccg
    14581 cgaggccgtc cgccgcggtg acgcctaccg cgaccgcctg tccgacctgg cgtgccgtcg
    14641 tgtgccgacc gccgaggcgg tgctgagcct gctctgggag gacgcgcgcg ccgcctgcga
    14701 caccttgctg ccgcactacc ggcgtggcgc cggcctgtgc gcctgcgtct tcgtgccgct
    14761 gaacccctac gccgacggcc gccgggccgt cgcggaagcc gccgcgctgc ggtggacggt
    14821 cgaccgcccc aacacggtgg tgtccgtgca cctggcgcgc ggcggggtgc cgctcgtcgg
    14881 cgacctgctg gcacggggca tcagcgtcga cgtccggtcg ctgttcacgc tccagcagtt
    14941 cgacctgctc ttcgaggagt tcctcggcgg cctggagcgg gcgcgtgacg ccgggtgcga
    15001 cctgtcgggc atccacttcg ccgcctccgt cccgctgcgc gtgctggacg agacgatcgc
    15061 cgcccggctg ggcgcgacgg cgtgccgcga ggagtgggcc gtggccgtcg cccggctgct
    15121 gcaccaccgc cgcgaacagc tgatggacgg cgcccgctgg caggcgctgg tccgcgcggg
    15181 cgcccgcccg ccgcacttcg tctggtccgc ccgcgaggcg cccgtccggg aagcggtgcg
    15241 ctacctggag gagctggtgg gctggaacag cgtcttctcg gcgggacccg tcaccctgcg
    15301 ggccgtgcgc gcccgggccg agctgcgggg cgacaccatc agcggtacgg aggcgcactc
    15361 ccggcatgtg ctgtcggccc tgcgctgccg ggaggtcgac ctgggggcga tgggcctcga
    15421 actgcagcag gctcagctcg aggccgcacg cggcgagtgg acggagctgt gcggggcggt
    15481 cggcgccacc ctcgggcacg tctgaaccgc ctcaccgaac ccgcgcggga ccgcccccgg
    15541 caggtcccgg gtacctcgtc gcgaacgcgg cgacccgccc ggcgtccagc cgcagccggg
    15601 atccggcgaa ccgctgccgc atccggcggt cgtgggtcac gaccaccacc gctccccggt
    15661 agcccgtcag tgcctgttcc agctcctcca cgagcgcggg cgacaggtgg ttggtgggct
    15721 cgtccagcag cagcaggtcc accgggtcgc tcaccagccg ggcgagctcg atcctgcggc
    15781 gctgcccgta ggacagctcg ccgacccgcc gccgcaggtc gtcggggccg aacaggccga
    15841 gggagagcag ctcctcgacg tgctcgtcgg gatgcccgcc ccggccctgg gcgaaggcct
    15901 gcggcacggt catggccgac ggccacggtg tggggtcctg ccgcagatgg cccacgcggc
    15961 cggtcacggt gaccgagccg ccgtcggccg ccagctcacc ggccagcacg cgcagcagtg
    16021 tcgtcttccc cgcgccgttg gggcccgtga ccagcagccg ctcaccgcgg ccgatgcgca
    16081 gcgacccgac ccgcagccgg ccgtccaccc gtacgtccgc cagctccgcc accgtctccg
    16141 ccgccgtttc cgtcacggct tccggagccg tctccgccgc cggccggtcg gtggtggtgg
    16201 agagcacggc cgtgaaggcg agcgggtccg cgggccgggc gacggcgttc tccgtgagcc
    16261 gtgccacccg ctccttggcg ttgcggatcc ggaccatcgc gccatggccc cggccccgca
    16321 tccggtacag gcctgcgccg aagacggcaa acgggagctt gcgcgggatg ccgtccatcc
    16381 gcgacacgtg ggtggacacc agctcgcggt tgctgtccag ctcggcgcgc cactgctcgt
    16441 actcccgcag ccggcggcgg cgctccgcgg gcttggcgga caggtagccc tcgtagccgt
    16501 tgccgtagcg ggtgacgcgg ccggagtcca cctccaggac ggtcgtggtg agccgttcca
    16561 ggaacacccg gtcgtgggtc accgcgacga cggtgccccg gtgccggcgc agatgctcct
    16621 cgagccagat caccgcgtgt tcgtcgaggt cgttggtggg ctcgtccagc agcagcagct
    16681 ccggggcgga ggccagtgtc ccggccaggg ccaggcgcga ccgctcaccg ccggacaggg
    16741 tcgccagcgg ccggtcgcgc tccaggcccg gcaggcccag gtggtgcagc gcgatgtcga
    16801 cccggctatc ggcctcgtaa ccaccgcggg cctggtaccg gtcaaccaag gcggcgaagg
    16861 actcgaccaa gccggccaac tcggggtcct ggccggactg gaagggccgc tccccgagct
    16921 cggcctccga ccgccgcaag ccgtcctcca agtcgcgaag gtcggcgagc gcgaggtcga
    16981 cggcgtcctg gacgacggcg ttctccggca gctccagcga ctgcggcaga taccccaccc
    17041 cgccgggtgc caccacggtg accgccccgt tgtcgggcgt gtcccggccc gcgatcagcc
    17101 tgagcagtgt cgacttgccc gaaccgttgt cgccgacgat gccgatcctc tcgccgggcc
    17161 tgacggtgaa gtccacgcgg tccaggacca cgtggccggc gaagcgcttg gtgatgtcgt
    17221 gcagggcgaa ttgggcaaca cgcatggacg gtcctcctgt gtacagccga tacggggatg
    17281 ccgtgtccgc gtacgccgca gccgcagggg gataccacaa agggaacacg ccggaacggc
    17341 cgtactcatc ggccacaggc ggtgcggagg tacgcgggag gtgtgacgtc ggagcagcgc
    17401 tcgacgcggt cacacactcg gatcggctat cacagagaac ccatgcgggt gatcttatca
    17461 caccgcacgg ggtgtcgcag ccctgatcac tcgccaagat gcgacgcgga tgcgctgaag
    17521 ctagtttggg gatatagagg ttgacccgaa ccccggggct ccgacgctgt cggcttcggg
    17581 cccggggttt cccgcatgat cgaggaacag cgtcatgccc gaccgacaaa ccgctgacaa
    17641 cggcctcagc agcttctcgt tgcacacctt cgacgagacg tcgtcccccg ccgtcgcgca
    17701 actgcaggag gagcgagccg cacgtccccg cgtcaggccg gaggggctcg agagcgagcg
    17761 cgacctcgat cccgagacgg cggcgcgccg ctacctcgac caggccctgg caagcgcgac
    17821 ggtgccgtcc ttcaccgctc cggtggcgaa cggagtcgcc agccggttca agacgatcgg
    17881 cacggagacg gtcccgctca ccgacacccg cacggtgaag gttccgccag acactgaacg
    17941 gcatcccggt ctacggctca ctggtgaccg tggaactcga caaggccaac gatctgatcg
    18001 gcatcgactc ggctctcggc gagccccagg gggtcgac
//
