BGC0000020: maytansine biosynthetic gene cluster from Actinosynnema pretiosum subsp. auranticum
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Location: 1 - 82,746 nt. (total: 82,746 nt).
This entry is originally from NCBI GenBank AF453501.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000020
Short description maytansine biosynthetic gene cluster from Actinosynnema pretiosum subsp. auranticum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AF453501.1
via
Compounds
  • maytansine
  • ansamitocin P-3
Species Actinosynnema pretiosum subsp. auranticum [taxonomy]
References
Chemical products information
maytansine Evidence:
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C34H46Cl1N3O10
Chemical database entries
PubCHEM
ansamitocin P-3 Evidence:
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C32H43Cl1N2O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAM54115.1
  • asm37
 2 - 1678 (+) unknown
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    • AAM54114.1
    • asm36
    		 1825 - 2142 (+) unknown
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      • AAM54113.1
      • asm35
      		 2129 - 3307 (-) bicyclomycin resistant protein
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        • AAM54112.1
        • asm34
        		 3450 - 4064 (-) transcriptional regulator
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          • AAM54111.1
          • asm33
          		 4151 - 4723 (+) dihydrofolate reductase
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            • AAM54110.1
            • asm32
            		 4854 - 5057 (-) unknown
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              • AAM54109.1
              • asm31
              		 5415 - 6461 (+) RNA polymerase sigma factor
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                • AAM54108.1
                • asm30
                		 6501 - 9518 (-) cytochrome P450
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                  • AAM54107.1
                  • asm29
                  		 9664 - 10245 (+) transcriptional regulator
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                    • AAM54106.1
                    • asm28
                    		 10393 - 10857 (+) unknown
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                      • AAM54105.1
                      • asm27
                      		 10912 - 11937 (-) glucose 1-dehydrogenase
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                        • AAM54104.1
                        • asm26
                        		 12117 - 12359 (+) acyl carrier protein
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                          • AAM54103.1
                          • asm25
                          		 12455 - 13663 (-) glycosyltransferase
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                            • AAM54076.1
                            • asmB
                            		 13741 - 22962 (-) polyketide synthase
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                              • AAM54075.1
                              • asmA
                              		 22987 - 37041 (-) polyketide synthase
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                                • AAM54102.1
                                • asm24
                                		 37440 - 38606 (-) 3-amino-5-hydroxybenzoate synthase
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                                  • AAM54101.1
                                  • asm23
                                  		 38826 - 39260 (+) 5-deoxy-5-amino-3-dehydroquinate dehydratase
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                                    • AAM54100.1
                                    • asm22
                                    		 39525 - 40280 (-) kinase
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                                      • AAM54099.1
                                      • asm21
                                      		 41063 - 43069 (-) O-carbamoyltransferase
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                                        • AAM54098.1
                                        • asm20
                                        		 43291 - 43638 (+) unknown
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                                          • AAM54097.1
                                          • asm19
                                          		 43652 - 44788 (-) 3-O-acyltransferase
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                                            • AAM54096.1
                                            • asm18
                                            		 44814 - 47555 (-) transcriptional activator
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                                              • AAM54095.1
                                              • asm17
                                              		 47733 - 48236 (-) O-methyltransferase
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                                                • AAM54094.1
                                                • asm16
                                                		 48388 - 49701 (-) unknown
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                                                  • AAM54093.1
                                                  • asm15
                                                  		 49782 - 50855 (-) acyl-CoA dehydrogenase
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                                                    • AAM54092.1
                                                    • asm14
                                                    		 50890 - 51162 (-) acyl carrier protein
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                                                      • AAM54091.1
                                                      • asm13
                                                      		 51159 - 52184 (-) 3-hydroxyacyl-CoA dehydrogenase
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                                                        • AAM54090.1
                                                        • asm12
                                                        		 52441 - 53766 (+) halogenase
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                                                          • AAM54089.1
                                                          • asm11
                                                          		 53871 - 55313 (+) oxygenase
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                                                            • AAM54088.1
                                                            • asm10
                                                            		 55310 - 56194 (+) methyltransferase
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                                                              • AAM54087.1
                                                              • asm9
                                                              		 56445 - 57224 (-) amide synthase
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                                                                • AAM54078.1
                                                                • asmD
                                                                		 57226 - 67200 (-) polyketide synthase
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                                                                  • AAM54077.1
                                                                  • asmC
                                                                  		 67210 - 71979 (-) polyketide synthase
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                                                                    • AAM54086.1
                                                                    • asm8
                                                                    		 72035 - 75388 (-) transcriptional regulator
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                                                                      • AAM54085.1
                                                                      • asm7
                                                                      		 75589 - 76635 (+) methyltransferase
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                                                                        • AAM54084.1
                                                                        • asm6
                                                                        		 76761 - 77054 (-) unknown
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                                                                          • AAM54083.1
                                                                          • asm5
                                                                          		 77077 - 78327 (-) Na+/H+ antiporter
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                                                                            • AAM54082.1
                                                                            • asm4
                                                                            		 78336 - 80582 (-) ABC transporter
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                                                                              • AAM54081.1
                                                                              • asm3
                                                                              		 80623 - 80889 (-) unknown
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                                                                                • AAM54080.1
                                                                                • asm2
                                                                                		 81057 - 81701 (-) transcriptional repressor
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                                                                                  • AAM54079.1
                                                                                  • asm1
                                                                                  		 81928 - 82653 (+) quinone oxidoreductase
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                                                                                    Biosynthesis information
                                                                                    Annotation changelog

                                                                                    Entry version: 2

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2019-10-16
                                                                                    Migrated from v1.4
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    2019-10-16
                                                                                    Updated compound(s) information (NPAtlas curation)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 1

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2015-06-12
                                                                                    Submitted
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    Detailed domain annotation
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